Synthesis, in vitro Antimicrobial assay and Molecular Docking Studies of some new Symmetrical Bis-Schiff Bases and their 2-Azetidinones.

Abstract

Four membered cyclic amides that are a broadly utilized class of antimicrobial agents up to now. Moreover, Symmetrical Bis-Schiff bases constitute an extraordinary class of strained compounds with varied applications and building blocks for the synthesis of 2-Azetidinones antibiotics. Because of those over biological significance, this study concludes a versatile synthetic precursor for the synthesis of the new Symmetrical Bis-Schiff bases and 2-Azetidinones in an exceedingly high yield. 2-Azetidinones were synthesized through [2+2] dichloroketene-imine cycloaddition reaction. The structures of the synthesized compounds were characterized by FT-IR, 1 H-NMR, and 13 C-NMR. Additionally, the products were assayed against two antibacterial types Grampositive (S. aureus) and Gram-negative (E. coli) microorganisms and two varieties of fungal strains A. niger, T. mentagrophytes by broth microdilution method. As a result, all synthesized compounds displayed good antimicrobial activities against resistant strains. Finally, molecular docking studies were explained the inhibitory activities for the new products with the target (PDB ID: 1MWU) methicillin acyl-Penicillin binding protein 2a from methicillin-resistant Staphylococcus aureus in 7 6 resolution.

A synergistic investigation of azo-thiazole derivatives incorporating thiazole moieties: a comprehensive exploration of their synthesis, characterization, computational insights, solvatochromism, and multimodal biological activity assessment

“…Advances in pharmaceutical chemistry and drug delivery give rise to extended-release formulations, boosting patient compliance and treatment efficacy. [6][7][8][9] Recently, bacterial and inammatory infections have given rise to diverse and serious diseases. Thus, the discovery of novel antibacterial and anti-inammatory agents holds promise for mitigating these medical challenges.…”