Synthesis and study of controlled release of ofloxacin from polyester conjugates

Controlled polymerisation and purification of branched poly(lactic acid) surfactants in supercritical carbon dioxide

“…This trend was also observed when screening against E. coli (ESI Fig. S11 †) and is similar to observations made by Sobzcak Q5 et al, 70 who identified L-lactide to be slightly toxic against the bacteria and protozoa assessed, while purified PLA displayed no toxicity.…”

“…Although cell culture assays with mammalian cells are currently the most popular in vitro tests for evaluating toxicity, other assays involving bacteria and lower Eurkaryotes are often used as preliminary methods to indicate differences in toxicity between compounds. 70 As the growth of E. coli is known to be inhibited by tin, 49 and as PLA has previously been evaluated against S. aureus 50,51…”

Antibiotic-containing polymers for localized, sustained drug delivery

“…Similarly, ciprofloxacin (CIP) [31] and ofloxacin (OFL) [32] were conjugated to the hydroxyl ends of polyesters with two, three, four, or six arms. The polyesters were synthesized using CL, rac-lactide or L-lactide with GL, PET, dipenthaerythritol (DPET), or PEG as initiators to afford the respective arm lengths using the same method as described in the previous article.…”

Enzyme‐catalyzed ring‐opening polymerization of cyclic esters in the presence of poly(ethylene glycol)

“…Aliphatic polyesters are widely used for medical applications, such as drug‐delivery systems or resorbable implants 1–9. Poly(ϵ‐caprolactone) (PCL), polyglycolide, polylactide (PLA), and their copolymers are degraded by the hydrolysis of their ester linkages in physiological conditions, such as in the human body.…”