Antibiotic-containing polymers for localized, sustained drug delivery

Stebbins, Nicholas D.; Ouimet, Michelle A.; Uhrich, Kathryn E.

doi:10.1016/j.addr.2014.04.006

Cited by 119 publications

(79 citation statements)

References 54 publications

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“…[6] 3 Curcumin (Cur) is extracted from turmeric as food additive or traditional medicine for centuries in China and India. It has been found that Cur has very low toxicity or even nontoxicity on healthy cells, but selective toxicity on many cancer cells.…”

mentioning

confidence: 99%

Intracellularly Degradable, Self‐Assembled Amphiphilic Block Copolycurcumin Nanoparticles for Efficient In Vivo Cancer Chemotherapy

Guo

Shen

et al. 2015

Adv Healthcare Materials

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Chemotherapy is widely used in various cancer treatments. However, current cancer chemotherapy has a major limitation: lacking of specific targeting ability. As a result, it kills both cancerous and healthy cells, causing severe adverse side-effects and toxicity to patients which limits the dose regime and allows tumour to gain resistance. One approach to address this problem is the development of nanoscale drug delivery systems (NDDSs) which can exploit characteristic properties of tumour, such as the enhanced permeation and retention (EPR) effect, [1] and over-expressed cell-surface receptors, [2] to achieve targeted delivery. [3] Despite significant research achievements, most of the current NDDSs, especially those in clinical trials or usage, e.g. drug encapsulated lipids vesicles or polymer micelles, [4] polymerdrug conjugates, and albumin-based nanoparticles, [5] mostly rely on passive targeting and generally lack the ability of active targeting. Moreover, drugs are mostly physically encapsulated or entrapped into the NDDSs, where drug release is mainly achieved via passive diffusion, making it difficult to achieve controlled release, a vital property for high therapeutic 2 efficacy. As a result, most of the drug payloads may have been released before reaching the target sites, leading to reduced therapeutic efficacy and causing adverse side-effects.Furthermore, most NDDSs also suffer from drawbacks such as low drug loading (e.g.antibody-drug conjugates) and/or burst release (e.g. micelles/liposomes). To date, none of the current NDDSs can satisfy all of the requirements of an "idea NDDS" outlined by Langer et al. [3a] To make best use of the advantages of current NDDSs (passive and active targeting delivery to tumour) and overcome their drawbacks (unnecessary and even harmful on-way drug release before entering tumour cells and/or only a small quantity of drugs together with the nano-carriers entering tumour cells) due to the physical incorporation or encapsulation of drugs in NDDSs, which often leads to uncontrolled drug release via diffusion, we take a new approach to prepare NDDSs which is based on so-called poly(active pharmaceutical ingredient) (PAPI) strategy where the APIs are incorporated into an intracellular cleavable polymer backbone (not physically incorporated in drug carriers) in combination with selfassembly characteristics of amphiphilic block copolymers. Here PAPI is defined as a polymer prepared by polycondensation of an API or its derivative having the same or similar bioactivity as a co-or sole-monomer. Considerable advantages here are that the physicalchemical properties of the PAPIs can be readily tailored by changing co-monomers or via chemical modifications. The PAPIs can be further made into various NDDSs where the API release can be controlled via stimuli triggered polymer degradation, overcoming the drawback of un-controlled, diffusion based drug release character commonly experienced in physically incorporated systems. In principle, any drug molecules/derivatives containi...

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mentioning

confidence: 99%

Intracellularly Degradable, Self‐Assembled Amphiphilic Block Copolycurcumin Nanoparticles for Efficient In Vivo Cancer Chemotherapy

Guo

Shen

et al. 2015

Adv Healthcare Materials

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“…1 So far, many different types of antimicrobial polymers have been devised, 2-7 including antimicrobial cationic polymers, 8,9 biocide-released polymers 10,11 and so forth. Among them, antimicrobial cationic polymers have attracted most of the attentions in this field, because compared with antibiotics, antimicrobial cationic polymers may not induce serious microbial drug resistance.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial cationic polymers: from structural design to functional control

Yang

Cai

Huang

et al. 2017

Polym J

207

174

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Antimicrobial cationic polymers mainly contain two functional components: the cationic groups and the hydrophobic groups. The antimicrobial activity is influenced by the type, amount, location and distribution of these two components. This review summarizes the designs and syntheses of antimicrobial cationic polymers by controlling the above two factors. It involves the structural designs from primary to secondary structures, from covalent to noncovalent syntheses and from bulk to surface. Furthermore, it will discuss how to advance structural designs toward functional controls for optimizing the antimicrobial performances and biocompatibility of antimicrobial cationic polymers. It is anticipated that this review will provide some guidelines for developing molecular engineering of antimicrobial cationic polymers with tailor-made structures and functions.

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“…In literature, the antibiotic‐conjugated polymeric systems can be fabricated via pendant conjugation of antibiotics to the backbone chain of polymer or the polymerization of antibiotic‐containing small molecule with polymerizable moieties, as depicted in Figure . For example, penicillin G and penicillin V moieties were conjugated to the end group of poly(2‐oxazoline)s, resulting in higher stability and antibacterial activity in the existence of penicillinase.…”

Section: Biodegradable Polymeric Nanosystems Containing Antibioticsmentioning

confidence: 99%

Biodegradable Antibacterial Polymeric Nanosystems: A New Hope to Cope with Multidrug‐Resistant Bacteria

Ding

Wang

Tong

2019

Small

153

108

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Figure 17. a) Schematic illustration for the fabrication of chlorhexidine diacetate (CHX)-loaded antibacterial nanogels for hemostasis and wound healing applications. b) Wound healing processes after treated with different materials. Reproduced with permission. [109] Figure 25. a) Schematic illustration, b) synthetic route, and c) TEM images of phosphonium-functionalized polymer micelles. Reproduced with permission. [126]

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Antibiotic-containing polymers for localized, sustained drug delivery

Cited by 119 publications

References 54 publications

Intracellularly Degradable, Self‐Assembled Amphiphilic Block Copolycurcumin Nanoparticles for Efficient In Vivo Cancer Chemotherapy

Intracellularly Degradable, Self‐Assembled Amphiphilic Block Copolycurcumin Nanoparticles for Efficient In Vivo Cancer Chemotherapy

Antimicrobial cationic polymers: from structural design to functional control

Biodegradable Antibacterial Polymeric Nanosystems: A New Hope to Cope with Multidrug‐Resistant Bacteria

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