Synthesis and spectroscopic studies of some new azobenzenesulfonamide

Soliman, Nanees N.; Fadda, Ahmed A.; Bayoumy, Nesma M.

doi:10.1080/00405000.2019.1633845

Cited by 3 publications

(1 citation statement)

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“…This is caused by the interaction of an aromatic system of p-electrons with a solvent molecule, the nitrogen atom, and the synthesized azo compounds non-bonding electrons. [40] Due to n p* electronic transition in the azo group, the absorption maxima of the dyes F1-F2 and P1-P2 lie in the range of 410 nm to 481 nm with a marginal variation. The results are summarized in Table 2, It has been found that the substituent effect also plays a signi cant role in the absorption spectra of the dyes F1-F2 and also introduces electrondonating substituents like CH 3 and OH on the diazo component.…”

Section: Photophysical Studiesmentioning

confidence: 99%

Design of Sulfonamide Substituted Mono-Azo Derivatives: Photophysical and Biological Activity

Shekharagouda,

et al. 2024

Preprint

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Novel Azo-linked substituted sulfonamides were synthesized via diazo coupling reactions and characterized by FT-IR, UV-vis, HR-MS and 1H NMR spectroscopic techniques. The newly synthesized compounds were examined for their in vitro antibacterial activity against Staphylococcus aureus and Escherichia coli strains using the disc-agar diffusion method, the dye F1 exhibited more zone inhibition 25mm in the concentration 75µl/ml in gram-negative bacteria when compared with common antibiotic Ciprofloxacin. The photophysical properties was estimated using DFT-B3LYP-6-31 + G (d) basis set. The correlation between the HOMO LUMO energy gap and antibacterial activity was investigated computationally. Additionally, in silico molecular docking was carried out. Among four compounds, compound F2 has the highest binding energy against cyclin dependent kinase (ΔGb = -9.8 kcal/mol).

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Section: Photophysical Studiesmentioning

confidence: 99%