Synthesis and Medicinal Evaluation of Mannich Bases Carrying Azetidinone Moiety

Prasad, Aluru Guru; Raju, Kakarlapudi Ranga; Prasad, A. Raghavendra Guru; Kumar, B. Santosh; Ravindranath, Lakshmana Rao Krishna Rao

doi:10.4328/jcam.2408

Cited by 3 publications

(3 citation statements)

References 6 publications

(6 reference statements)

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“…This type of absorption confirms the octahedral geometry, which is further evident by the magnetic moment value at 4.73B. M [12].…”

Section: Uv-visible Spectroscopic Measurementssupporting

confidence: 75%

Synthesis, Biological Study, Dna Interaction of Mannich Base Metal Complexes Derived From Benzamide

Sudhasankar

2021

Int J Curr Pharm Sci

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Objective: Coordination compounds occur widely in nature and they comprise a large share of current inorganic research. The Mannich reaction is a classic method for the preparation of Mannich bases, namely, β amino compounds, which are heterocyclic. Methods: A novel Mannich base of N-((3,4-dimethoxyphenyl)(2,5-dioxopyrrolidin-1-yl) methyl)benzamide and its coordination complexes with transition metals Mn and Co have been synthesized and characterized by elemental analysis, molar conductance, magnetic susceptibility measurements, UV-Visible, IR, NMR, and Mass spectral studies. Results: Based on the magnetic moment and UV-Visible spectral data, octahedral geometries were assigned for the metal complexes. The metal complexes were screened for antifungal activity. Conclusion: the metal complexes have shown good activity than the ligand. The binding of selected metal complexes with calf thymus DNA was investigated. It is found that the cobalt (II) metal complex of the ligand showed efficient DNA binding ability.

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“…This type of absorption confirms the octahedral geometry, which is further evident by the magnetic moment value at 4.73B. M [12].…”

Section: Uv-visible Spectroscopic Measurementssupporting

confidence: 75%

Synthesis, Biological Study, Dna Interaction of Mannich Base Metal Complexes Derived From Benzamide

Sudhasankar

2021

Int J Curr Pharm Sci

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“…Piperazine citrate was used as standard drug. The compound 19h containing N-methylpiperazine moiety was found to have significant anthelmintic activity [ 47 ].…”

Section: Biological Activitiesmentioning

confidence: 99%

Mannich Bases: An Important Pharmacophore in Present Scenario

Bala

Sharma

Kajal

et al. 2014

International Journal of Medicinal Chemistry

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Mannich bases are the end products of Mannich reaction and are known as beta-amino ketone carrying compounds. Mannich reaction is a carbon-carbon bond forming nucleophilic addition reaction and is a key step in synthesis of a wide variety of natural products, pharmaceuticals, and so forth. Mannich reaction is important for the construction of nitrogen containing compounds. There is a number of aminoalkyl chain bearing Mannich bases like fluoxetine, atropine, ethacrynic acid, trihexyphenidyl, and so forth with high curative value. The literature studies enlighten the fact that Mannich bases are very reactive and recognized to possess potent diverse activities like anti-inflammatory, anticancer, antifilarial, antibacterial, antifungal, anticonvulsant, anthelmintic, antitubercular, analgesic, anti-HIV, antimalarial, antipsychotic, antiviral activities and so forth. The biological activity of Mannich bases is mainly attributed to α, β-unsaturated ketone which can be generated by deamination of hydrogen atom of the amine group.

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“…The spectra were recorded in the range of 250-900 nm at room temperature using 10 -3 M solution with DMSO as a solvent. The electronic transitions [31][32][33][34] were interpreted and summarized, Table-3.…”

Section: Ft-ir Spectramentioning

confidence: 99%

Untitled

2018

RJLBPCS

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Mannich bases form promising group of compounds which could be a source of potential candidates for future drugs. The knowledge about their biological activities at the cellular and tissue level is needed to be explored. The toxicity of vital thiol group present in the microorganisms is attacked by the active units released by the Mannich bases. A number of bi-functional Mannich bases display anticancer and antitumor activities and are often formulated as prodrugs. The lipophilicity of Mannich bases and their metal complexes resist the growth of harmful microorganisms. As a result, the search for finding more effective new drugs is acquired more attention [1-3]. The presence of aminoalkyl Mannich side chain is essential to formulate water soluble antitumour agent. The gatifloxacin Mannich derivatives showed excellent anticancer activity compared to the standard anticancer drug etoposide. Due to the versatile utility of the Mannich bases, we report here the synthesis of a new compound 1-[morpholino(4-nitrophenyl)methyl]-3-phenylurea (NMP)and its complexeswith variety of transition metals such as Co(II), Mn(II), Ni(II), Cu(II) and Zn(II). NMP was derived by reacting 4-nitrobenzaldehyde, morpholine and N-phenylurea. The ligand and its complexes were characterized using various analytical (Chemical assays, Melting point, Elemental analysis, TLC and TGA) and spectral studies (FT-IR, UV-Visible, 1 H NMR, 13 C NMR and Mass). The compound and its complexes were examined at various concentrations for DPPH free radical scavenging and anti-inflammatory activity.

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Synthesis and Medicinal Evaluation of Mannich Bases Carrying Azetidinone Moiety

Cited by 3 publications

References 6 publications

Synthesis, Biological Study, Dna Interaction of Mannich Base Metal Complexes Derived From Benzamide

Synthesis, Biological Study, Dna Interaction of Mannich Base Metal Complexes Derived From Benzamide

Mannich Bases: An Important Pharmacophore in Present Scenario

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