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Abstract

Mannich bases form promising group of compounds which could be a source of potential candidates for future drugs. The knowledge about their biological activities at the cellular and tissue level is needed to be explored. The toxicity of vital thiol group present in the microorganisms is attacked by the active units released by the Mannich bases. A number of bi-functional Mannich bases display anticancer and antitumor activities and are often formulated as prodrugs. The lipophilicity of Mannich bases and their metal complexes resist the growth of harmful microorganisms. As a result, the search for finding more effective new drugs is acquired more attention [1-3]. The presence of aminoalkyl Mannich side chain is essential to formulate water soluble antitumour agent. The gatifloxacin Mannich derivatives showed excellent anticancer activity compared to the standard anticancer drug etoposide. Due to the versatile utility of the Mannich bases, we report here the synthesis of a new compound 1-[morpholino(4-nitrophenyl)methyl]-3-phenylurea (NMP)and its complexeswith variety of transition metals such as Co(II), Mn(II), Ni(II), Cu(II) and Zn(II). NMP was derived by reacting 4-nitrobenzaldehyde, morpholine and N-phenylurea. The ligand and its complexes were characterized using various analytical (Chemical assays, Melting point, Elemental analysis, TLC and TGA) and spectral studies (FT-IR, UV-Visible, 1 H NMR, 13 C NMR and Mass). The compound and its complexes were examined at various concentrations for DPPH free radical scavenging and anti-inflammatory activity.