Synthesis and inhibitory effect of piperine derivates on monoamine oxidase

Piperine derivatives as potential inhibitors of Survivin: An in silico molecular docking

“…Subsequently, the compounds that have the best docking results will be synthesized and sent to the laboratory for more analyses. Regarding the ability of Piperine in inhibiting Survivin, a group of 18 previously synthesized Piperine derivatives has been chosen from the literature to evaluate their inhibitory effects against Survivin (Table 1) [20].…”

“…For this purpose, in the present study the interactions of this natural compound and some of its previously synthesized analogs with Survivin have been investigated using molecular docking tools. The selected Piperine analogs have been previously synthesized and showed inhibitory activity on monoamine oxidase [20]. The results of this study would help us to explore structure-activity relationship of these analogs that consequentely would lead us to design new compounds with higher efficacy.…”

Total monoamine oxidase (MAO) inhibition by chestnut honey, pollen and propolis

“…Previous studies to date have assessed the antioxidant, antimicrobial, antiinflammatory, anti-carcinogenic and carbonic anhydrase (CA) inhibitory effects and the hepatoprotective role of the bee products 2,[7][8][9][10][11][12][13][14][15][16] . Similarly, MAO is inhibited by some plant extracts with a high content of phenolic compounds [17][18][19] and some synthetic hydrazines 20 . There are information gaps on MAO inhibition by bee products, however, which this study is intended to help fill.…”

Discovery of 3‐Hydroxy‐3‐phenacyloxindole Analogues of Isatin as Potential Monoamine Oxidase Inhibitors

“…Visuali nspection of binding modes of all inhibitors within the active site of MAO-A and MAO-B was done to gain more insight into the binding orientation and potentiali nhibitorenzymei nteractions. The inhibitor binding site of MAO-A is [29] 0.00042 --0.26 ---4 [30] 3.00 À5.3 130.82 7000 ---5 [31] 67.25 AE 1.02 --0.019 AE 0.0008 ---6 [32] 0.412 AE 0.123 --0.004 AE 0.0009 À6.5116.8- as ingle cavity that extendsf rom the flavin ring to the cavityshaping loop. The volumeo ft his cavity is estimated to be~5 00 3 and is quite hydrophobic.…”

“…[25][26][27] Figure1 illustrates af ew examples of isatin derivatives (1 and 2)t hat possessg ood activity against MAO, and few reference MAO inhibitors (compounds 3-6). [28][29][30][31][32] Isatin is therefore ab iologically validated startingp oint for the design of chemical libraries directed at targeting the MAO isozymes. [22,23] Due to the privileged nature of isatin, it can be predicted that chemical libraries of this scaffold should yield medicinally active compounds with high hit rates.…”