Synthesis and in vitro/in vivo anti-cancer evaluation of curcumin-loaded chitosan/poly(butyl cyanoacrylate) nanoparticles

Duan, Jinghua; Yang-de, Zhang; Han, Shiwei; Chen, Yuxiang; Li, Bo; Liao, Mingmei; Chen, Wei; Deng, Xingming; Zhao, Jinfeng; Huang, Boyun

doi:10.1016/j.ijpharm.2010.08.033

Cited by 155 publications

(94 citation statements)

References 40 publications

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“…The curcumin particles showed comparable in vitro efficacy to the free drug in hepatocarcinoma cells, and inhibited the growth of the tumors in vivo in murine xenograft models of hepatic carcinoma, having an important antiangiogenic effect [461].…”

Section: Nanoparticles Which Incorporate Curcuminmentioning

confidence: 92%

“…Also working with curcumin Duan and co-workers [461] synthesized novel positive-charged curcumin-loaded poly(butyl) cyanoacrylate nanoparticles coated with chitosan (200 nm) with high encapsulation efficiencies (90 %), increasing the solubility of curcumin and avoiding the drug clearance by the RES system. The curcumin particles showed comparable in vitro efficacy to the free drug in hepatocarcinoma cells, and inhibited the growth of the tumors in vivo in murine xenograft models of hepatic carcinoma, having an important antiangiogenic effect [461].…”

Section: Nanoparticles Which Incorporate Curcuminmentioning

confidence: 99%

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Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy

Pérez-Herrero

Fernández‐Medarde

2015

European Journal of Pharmaceutics and Biopharmaceutics

1,317

715

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Cancer is the second worldwide cause of death, exceeded only by cardiovascular diseases. It is characterized by uncontrolled cell proliferation and an absence of cell death that, except for hematological cancers, generates an abnormal cell mass or tumor. This primary tumor grows thanks to new vasculatization and, in time, adquires metastatic potential and spreads to other body sites, which causes metastasis and finally death. Cancer is caused by damage or mutations in the genetic material of the cells due to environmental or inherited factors. While surgery and radiotherapy are the primary treatment used for local and non-metastatic cancers, anti-cancer drugs (chemotherapy, hormone and biological therapies) are the choice currently used in metastasic cancers. Chemotherapy is based on the inhibition of the division of rapidly growing cells, which is a characteristic of the cancerous cells, but unfortunately, it also affects normal cells with fast proliferation rates, like the hair follicles, bone marrow and gastrointestinal tract cells, generating the characteristic side effects of chemotherapy. The indiscriminate destruction of normal cells, the toxicity of conventional chemotherapeutic Código de campo cambiado

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Section: Nanoparticles Which Incorporate Curcuminmentioning

confidence: 92%

Section: Nanoparticles Which Incorporate Curcuminmentioning

confidence: 99%

Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy

Pérez-Herrero

Fernández‐Medarde

2015

European Journal of Pharmaceutics and Biopharmaceutics

1,317

715

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“…Previous attempts at encapsulating curcumin in liposomes, phospholipid complexes, or other nanoparticle-based technologies have been reported, showing an improvement in water dispersibility and a longer circulation time (Tang et al, 2010;Duan et al, 2010;Kim et al, 2011) A possible nanosized delivery system is constituted by naturally available clay halloysite nanotubes (HNT). Halloysite has been found a viable and inexpensive nanoscale container for the encapsulation of biologically active molecules such as biocides and drugs, as Price et al (2001) first demonstrated.…”

Section: Introductionmentioning

confidence: 99%

Development and characterization of co-loaded curcumin/triazole-halloysite systems and evaluation of their potential anticancer activity

Riela

Massaro

Colletti

et al. 2014

International Journal of Pharmaceutics

109

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“…57 Pharmacokinetic studies reported that curcumin nano-formulation displayed a larger area under curve (AUC)-time curve as compared with free curcumin. [57][58][59] For example, encapsulation of curcumin by poly(lactic-co-glycolide) (PLGA) nanoparticles provided a significant higher maximal concentration (1000-fold increase) as compared with free curcumin following 60 min of i.v. administration in mice.…”

Section: Pathological Bone Environmentmentioning

confidence: 99%

Therapeutic actions of curcumin in bone disorders

2016

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Curcumin is the active component of turmeric extract derived from the Curcuma longa plant. In the last decade, curcumin has raised a considerable interest in medicine owing to its negligible toxicity and multiple therapeutic actions including anti-cancer, anti-inflammatory and anti-microbial activities. Among the various molecular targets of curcumin, some are involved in bone remodeling, which strongly suggests that curcumin can affect the skeletal system. The review sheds light on the current and potential applications of curcumin to treat bone disorders characterized by an excessive resorption activity. Within the scope of this review, the novel formulations of curcumin to overcome its physico-chemical and pharmacokinetic constraints are also discussed.

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Synthesis and in vitro/in vivo anti-cancer evaluation of curcumin-loaded chitosan/poly(butyl cyanoacrylate) nanoparticles

Cited by 155 publications

References 40 publications

Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy

Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy

Development and characterization of co-loaded curcumin/triazole-halloysite systems and evaluation of their potential anticancer activity

Therapeutic actions of curcumin in bone disorders

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