Development and characterization of co-loaded curcumin/triazole-halloysite systems and evaluation of their potential anticancer activity

Pharmaceutical properties of supramolecular assembly of co-loaded cardanol/triazole-halloysite systems

“…f-HNT spectrum (Curve b) exhibits, in addition to the characteristic stretching bands of pristine halloysite (Yuang et al, 2008), the stretching bands of triazolium moiety as we have previously reported (Riela et al, 2014).…”

“…When the cells were incubated with f-HNT, on the contrary, we observed a little cytotoxicity against the several cell lines (Riela et al, 2014). This is not surprisingly because we have developed a new system with triazole, which is known to possess biological activity.…”

“…2) improves the antitumor effect of curcumin in physiological medium when compared with the use of curcumin alone. It is interesting to note that the presence of the biological active triazolium moiety exerts a synergic effect with curcumin that carry out in an increased cytotoxic activity of the new nano-formulation, HNT-triazolium salts/Curcumin, against several tumor cell lines (Riela et al, 2014).…”

Palladium supported on Halloysite-triazolium salts as catalyst for ligand free Suzuki cross-coupling in water under microwave irradiation

“…First catalytic support was prepared by a synthetic route reported in literature [22]. The preparation of supported palladium nanoparticles, where the metal catalyst can be linked by electrostatic interactions in the HNT-IL support, was achieved by anion exchange from X − to PdCl 4 2− (toluene solution of Na 2 PdCl 4 ).…”

“…HNT-IL 1 and azido functionalized HNT was previous synthetized as reported in literature [22]. Halloysite was supplied by Applied Minerals.…”