Therapeutic actions of curcumin in bone disorders

Rohanizadeh, Ramin; Deng, Yi; Verron, Elise

doi:10.1038/bonekey.2016.20

Cited by 37 publications

(29 citation statements)

References 69 publications

(79 reference statements)

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“…It has attracted a considerable interest in medicine due to its negligible toxicity and multiple therapeutic effects including anti-cancer, anti-inflammatory and anti-microbial activities (Rohanizadeh et al ., 2016). Based on preclinical and limited clinical trials, curcumin has shown to be a safe and potential therapeutic agent against diseases, such as inflammatory bowel disease, pancreatitis, arthritis and chronic anterior uveitis, as well as certain types of cancers (Kunnumakkara et al ., 2008; Rohanizadeh et al ., 2016; Shehzad et al ., 2011). Studies, covering a treatment period of three months, have shown that curcumin does not possess acute toxicity at doses of 2 g/kg of body weight in mice and 8,000 mg/day in humans (Chainani-Wu, 2003; JS, 2009).…”

Section: Introductionmentioning

confidence: 99%

Curcumin alleviates lumbar radiculopathy by reducing neuroinflammation, oxidative stress and nociceptive factors

Xiao¹,

Ding²,

Fernandez³

et al. 2017

eCM

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Current non-surgical treatments for lumbar radiculopathy [e.g. epidural steroids and Tumour necrosis factor-α (TNF-α) antagonists] are neither effective nor safe. As a non-toxic natural product, curcumin possesses an exceptional anti-inflammatory profile. We hypothesised that curcumin alleviates lumbar radiculopathy by attenuating neuroinflammation, oxidative stress and nociceptive factors. In a dorsal root ganglion (DRG) culture, curcumin effectively inhibited TNF-α-induced neuroinflammation, in a dose-dependent manner, as shown by mRNA and protein expression of IL-6 and COX-2. Such effects might be mediated via protein kinase B (AKT) and extracellular signal regulated kinase (ERK) pathways. Also, a similar effect in combating TNF-α-induced neuroinflammation was observed in isolated primary neurons. In addition, curcumin protected neurons from TNF-α-triggered excessive reactive oxygen species (ROS) production and cellular apoptosis and, accordingly, promoted mRNA expression of the anti-oxidative enzymes haem oxygenase-1, catalase and superoxide dismutase-2. Intriguingly, electronic von Frey test suggested that intraperitoneal injection of curcumin significantly abolished ipsilateral hyperalgesia secondary to disc herniation in mice, for up to 2 weeks post-surgery. Such in vivo pain alleviation could be attributed to the suppression, observed in DRG explant culture, of TNF-α-elicited neuropeptides, such as substance P and calcitonin gene-related peptide. Surprisingly, micro-computed tomography (µCT) data suggested that curcumin treatment could promote disc height recovery following disc herniation. Alcian blue/picrosirius red staining confirmed that systemic curcumin administration promoted regeneration of extracellular matrix proteins, visualised by presence of abundant newly-formed collagen and proteoglycan content in herniated disc. Our study provided pre-clinical evidence for expediting this natural, non-toxic pleiotropic agent to become a new and safe clinical treatment of radiculopathy.

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Section: Introductionmentioning

confidence: 99%

Curcumin alleviates lumbar radiculopathy by reducing neuroinflammation, oxidative stress and nociceptive factors

Xiao¹,

Ding²,

Fernandez³

et al. 2017

eCM

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“…[24][25][26][27] Curcumin has shown bone anabolic properties, but lacks bone specificity. 28 Curcumin is hydrophobic, highly instable in vivo, and has poor bioavailability. 29 Therefore, it could be used as a hydrophobic drug model to test the efficacy of bone-specific amphiphilic nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

“…Curcumin has not only anticancer but also bone anabolic properties. 28 Curcumin enhances bone-forming "osteoblast" differentiation, and the curcumin analog inhibits boneresorbing "osteoclast" formation. 49 Therefore, curcumin released from (Asp) 8 -PEG-PCL might kill the cancer cells metastasized in bone niche, as well as maintain bone homeostasis and inhibit osteolysis.…”

mentioning

confidence: 99%

Design of polyaspartic acid peptide-poly (ethylene glycol)-poly (ε-caprolactone) nanoparticles as a carrier of hydrophobic drugs targeting cancer metastasized to bone

Liu¹,

Zeng²,

Shi

et al. 2017

IJN

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Treatment of cancer metastasized to bone is still a challenge due to hydrophobicity, instability, and lack of target specificity of anticancer drugs. Poly (ethylene glycol)-poly (ε-caprolactone) polymer (PEG-PCL) is an effective, biodegradable, and biocompatible hydrophobic drug carrier, but lacks bone specificity. Polyaspartic acid with eight peptide sequences, that is, (Asp) 8 , has a strong affinity to bone surface. The aim of this study was to synthesize (Asp) 8 -PEG-PCL nanoparticles as a bone-specific carrier of hydrophobic drugs to treat cancer metastasized to bone. 1 H nuclear magnetic resonance, Fourier transform infrared spectroscopy, and transmission electron microscopy data showed that (Asp) 8 -PEG-PCL nanoparticles (size 100 nm) were synthesized successfully. (Asp) 8 -PEG-PCL nanoparticles did not promote erythrocyte aggregation. Fluorescence microscopy showed clear uptake of Nile red-loaded (Asp) 8 -PEG-PCL nanoparticles by cancer cells. (Asp) 8 -PEG-PCL nanoparticles did not show cytotoxic effect on MG63 and human umbilical vein endothelial cells at the concentration of 10–800 μg/mL. (Asp) 8 -PEG-PCL nanoparticles bound with hydroxyapatite 2-fold more than PEG-PCL. Intravenously injected (Asp) 8 -PEG-PCL nanoparticles accumulated 2.7-fold more on mice tibial bone, in comparison to PEG-PCL. Curcumin is a hydrophobic anticancer drug with bone anabolic properties. Curcumin was loaded in the (Asp) 8 -PEG-PCL. (Asp) 8 -PEG-PCL showed 11.07% loading capacity and 95.91% encapsulation efficiency of curcumin. The curcumin-loaded (Asp) 8 -PEG-PCL nanoparticles gave sustained release of curcumin in high dose for >8 days. The curcumin-loaded (Asp) 8 -PEG-PCL nanoparticles showed strong antitumorigenic effect on MG63, MCF7, and HeLa cancer cells. In conclusion, (Asp) 8 -PEG-PCL nanoparticles were biocompatible, permeable in cells, a potent carrier, and an efficient releaser of hydrophobic anticancer drug and were bone specific. The curcumin-loaded (Asp) 8 -PEG-PCL nanoparticles showed strong antitumorigenic ability in vitro. Therefore, (Asp) 8 -PEG-PCL nanoparticles could be a potent carrier of hydrophobic anticancer drugs to treat the cancer metastasized to bone.

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“…To avoid such drawbacks, it is needed to utilize therapeutic agents with minimum side effects to normal organs. To address this need, scientists have investigated the use of a traditional medicine named curcumin in treatment of osteosarcoma . This can be administered for other cancer types like cervical cancer, colon cancer, lung cancer, pancreatic cancer, and breast cancer …”

Section: Introductionmentioning

confidence: 99%

“…Although curcumin demonstrates such benefits, its poor water solubility and fast degradation in physiological pH limit its effective practical usage. In fact, curcumin hydrophobicity disables its vascular and oral administration which results in poor absorption and reduced bioavailability after its administration . In order to overcome these problems, it is necessary to develop an adequate releasing formulations (hydrogels, liposome, dendrimer, micro/nano particles) for delivery of curcumin which has been explored for long time .…”

Section: Introductionmentioning

confidence: 99%

Curcumin-Loaded Starch Micro/Nano Particles for Biomedical Application: The Effects of Preparation Parameters on Release Profile

et al. 2019

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Although curcumin is highly cytotoxic against cancer cells, its hydrophobicity and fast degradation at physiological pH limit its effective practical application. To prevent such limitations, inexpensive curcumin‐loaded starch particles are synthesized in this research. Particles are prepared by water‐in‐oil (W/O) miniemulsion technique and an adsorption method is used for curcumin loading. Also, encapsulation efficiency (%EE) is improved by using pluronic F‐127 in the drug solution. Particles are characterized, swelling studies are performed, and MTT assays against human adipose mesenchymal stem cells (hAMSCs) and MG‐63 cells are utilized for investigations. Results indicate that crosslinker, surfactant, and stirring rate affect the swelling degree of bare particles as well as %EE and release profile of drug‐loaded particles. Moreover, swelling degree, %EE, and burst release are modeled by design of experiments via response surface method. Due to analysis of variance, the responses can be predicted by quadratic models within the design space. Also, cell viability studies depict that curcumin encapsulation improves its cytotoxic effect on MG‐63 cells due to its sustained release while it has no cytotoxic effect on hAMSCs. In addition, it can be concluded that curcumin sustained release plays a more crucial role on cell viability of cancer cells compared to %EE. Consequently, it can be stated that curcumin‐loaded starch particles have good potential as drug delivery systems for osteosarcoma therapy.

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Therapeutic actions of curcumin in bone disorders

Cited by 37 publications

References 69 publications

Curcumin alleviates lumbar radiculopathy by reducing neuroinflammation, oxidative stress and nociceptive factors

Curcumin alleviates lumbar radiculopathy by reducing neuroinflammation, oxidative stress and nociceptive factors

Design of polyaspartic acid peptide-poly (ethylene glycol)-poly (ε-caprolactone) nanoparticles as a carrier of hydrophobic drugs targeting cancer metastasized to bone

Curcumin-Loaded Starch Micro/Nano Particles for Biomedical Application: The Effects of Preparation Parameters on Release Profile

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Therapeutic actions of curcumin in bone disorders

Cited by 37 publications

References 69 publications

Curcumin alleviates lumbar radiculopathy by reducing neuroinflammation, oxidative stress and nociceptive factors

Curcumin alleviates lumbar radiculopathy by reducing neuroinflammation, oxidative stress and nociceptive factors

Design of polyaspartic acid peptide-poly (ethylene glycol)-poly (&epsilon;-caprolactone) nanoparticles as a carrier of hydrophobic drugs targeting cancer metastasized to bone

Curcumin-Loaded Starch Micro/Nano Particles for Biomedical Application: The Effects of Preparation Parameters on Release Profile

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Design of polyaspartic acid peptide-poly (ethylene glycol)-poly (ε-caprolactone) nanoparticles as a carrier of hydrophobic drugs targeting cancer metastasized to bone