Synthesis and in vitro Cytotoxicity of 1-Benzoyl-3-methyl Thiourea Derivatives

Design, molecular docking, and molecular dynamics of thiourea-iron (III) metal complexes as NUDT5 inhibitors for breast cancer treatment

“…Given their physical and biological properties, iron–salen complexes have been studied since 1931, and it has been established that salen complexes of Fe (III) exert anticancer effects on MCF-7 cells. Previously, we synthesized several derivatives of thiourea compounds and studied their activity in several cancer cell lines, including MCF-7, T47D, WiDr, and HeLa [ 31 , 32 , 34 ].…”

Rational Design, Synthesis and Cytotoxic Activity of N-(Phenylcarbamoyl)Benzamide on HeLa Cell Lines

“…Afterwards, the compound was translated into the SMILE format using the Online SMILES Translator (http://cactus.nci.nih.gov/translate/). In the SMILE format, the compound was processed using the pkCSM online tool (htpp://biosig.unimelb.edu.au/pkCSM/prediction) to predict the ADMET of the compounds [20,21].…”

“…The absorbance was higher when the cancer cells/normal cells were alive. Calculation of IC 50 was done by probit regression analysis using SPSS [13,20].…”

Enantiomeric separation of thiourea derivatives of naringenin on amylose and cellulose polymeric chromatographic chiral columns

“…Hu et al 16 described biological evaluation and phase transfer catalysts stimulating the one‐pot synthesis of N ‐aryl‐ N ′‐(4‐ethyloxy benzoyl)‐thiourea derivatives. Other authors reported analgesic and antioxidant, 17 antitumor agents and antimicrobial, 18–21 cytotoxic effects, 21,22 and anticancer activity 23,24 of the thiourea compounds. Therefore, an idea was generated to make a new compound using naringenin and thiourea.…”