Synthesis and in vitro bioactivity of three-dimensionally ordered macroporous-mesoporous bioactive glasses; 45S5 and S53P4

Auniq, Reedwan Bin Zafar; Pakasri, Nattawipa; Boonyang, Upsorn

doi:10.1007/s43207-020-00050-z

Cited by 4 publications

(6 citation statements)

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“…Two different 3DOM-MBGCs; 45S5 and S53P4 were synthesized via sol-gel method follow by published work [30]. The synthesis process went through hydrolysis and polycondensation of TEOS, TEP, CNT and NaNO 3 (Figure 1) with the appropriate mol ratio mentioned in Table 1.…”

Section: Preparation Of Bioactive Glass Ceramicsmentioning

confidence: 99%

“…In vibrational peak at 564 and 950 cm −1 correlates to the P-O vibrational peak. In addition, the O-H bonds of the water trapped inside Copyright [30]. Table 2.…”

Section: Assessment Of In Vitro Bioactivity Testmentioning

confidence: 99%

“…The average data of specific surface area, pore volume and pore diameter of 45S5 and S53P4 3DOM-MBGCs. Copyright [30].…”

Section: Assessment Of In Vitro Bioactivity Testmentioning

confidence: 99%

“…FTIR spectra of 45S5 bioactive glass ceramics with different soaking time in SBF solution. Copyright [30]. correlates to the vibration of Si-O-Si bond.…”

Section: Figurementioning

confidence: 99%

“…SEM images of 45S5 bioactive glass ceramics (a) before soaking in SBF solution and after soaking in SBF solution for (b) 1 day (c) 2 days (d) 3 days (e) 7 days and ( f) 7 days with higher magnification. Copyright[30].…”

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Three-Dimensionally Ordered Macroporous-Mesoporous Bioactive Glass Ceramics for Drug Delivery Capacity and Evaluation of Drug Release

Auniq¹,

Hirun²,

Boonyang³

2021

Advanced Ceramic Materials

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Bioactive glass ceramics (BGCs) have been used in orthopedic and dentistry due to having better osteoconductive and osteostimulative properties. This study aimed to evaluate and compare the drug release properties of two different BGCs; 45S5 and S53P4. The BGCs were composed with four phases of SiO2 – CaO – Na2O – P2O5 system, synthesized by sol–gel method using dual templates; a block-copolymer as mesoporous templates and polymer colloidal crystals as macroporous templates, called three-dimensionally ordered macroporous-mesoporous bioactive glass ceramics (3DOM-MBGCs). In vitro bioactivity test performed by soaking the 3DOM-MBGCs in simulated body fluid (SBF) at 37°C. The results indicated that, the 45S5 have the ability to grow hydroxyapatite-like layer on the surfaces faster than S53P4. Gentamicin drug was used to examine in vitro drug release properties in phosphate buffer solution (PBS). The amount of drug release was quantified through UV/Vis spectroscopy by using o-phthaldialdehyde reagent. S53P4 showed high drug loading content. The outcome of drug release in PBS showed that both S53P4 and 45S5 exhibited a slowly continuous gentamicin release. The resultant drug release profiles were fitted to the Peppas-Korsmeyer model to establish the predominant drug release mechanisms, which revealed that the kinetics of drug release from the glasses mostly dominated by Fickian diffusion mechanism.

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Section: Preparation Of Bioactive Glass Ceramicsmentioning

confidence: 99%

“…In vibrational peak at 564 and 950 cm −1 correlates to the P-O vibrational peak. In addition, the O-H bonds of the water trapped inside Copyright [30]. Table 2.…”

Section: Assessment Of In Vitro Bioactivity Testmentioning

confidence: 99%

“…The average data of specific surface area, pore volume and pore diameter of 45S5 and S53P4 3DOM-MBGCs. Copyright [30].…”

Section: Assessment Of In Vitro Bioactivity Testmentioning

confidence: 99%

“…FTIR spectra of 45S5 bioactive glass ceramics with different soaking time in SBF solution. Copyright [30]. correlates to the vibration of Si-O-Si bond.…”

Section: Figurementioning

confidence: 99%

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confidence: 99%

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