Three-Dimensionally Ordered Macroporous-Mesoporous Bioactive Glass Ceramics for Drug Delivery Capacity and Evaluation of Drug Release

Abstract

Bioactive glass ceramics (BGCs) have been used in orthopedic and dentistry due to having better osteoconductive and osteostimulative properties. This study aimed to evaluate and compare the drug release properties of two different BGCs; 45S5 and S53P4. The BGCs were composed with four phases of SiO2 – CaO – Na2O – P2O5 system, synthesized by sol–gel method using dual templates; a block-copolymer as mesoporous templates and polymer colloidal crystals as macroporous templates, called three-dimensionally ordered macroporous-mesoporous bioactive glass ceramics (3DOM-MBGCs). In vitro bioactivity test performed by soaking the 3DOM-MBGCs in simulated body fluid (SBF) at 37°C. The results indicated that, the 45S5 have the ability to grow hydroxyapatite-like layer on the surfaces faster than S53P4. Gentamicin drug was used to examine in vitro drug release properties in phosphate buffer solution (PBS). The amount of drug release was quantified through UV/Vis spectroscopy by using o-phthaldialdehyde reagent. S53P4 showed high drug loading content. The outcome of drug release in PBS showed that both S53P4 and 45S5 exhibited a slowly continuous gentamicin release. The resultant drug release profiles were fitted to the Peppas-Korsmeyer model to establish the predominant drug release mechanisms, which revealed that the kinetics of drug release from the glasses mostly dominated by Fickian diffusion mechanism.

Biodegradable electrospun poly(L‐lactide‐co‐ε‐caprolactone)/polyethylene glycol/bioactive glass composite scaffold for bone tissue engineering

“…These silanols facilitate the protein adsorption process, enhancing cell adhesion—an essential step in the bone formation process 39 . The detection of PO and SiO 4 further confirmed the bioglass 31–33 . EDS (Figure 1C) validated the components used in the bioglass synthesis and confirmed its chlorination.…”

“…39 The detection of P O and SiO 4 further confirmed the bioglass. [31][32][33] EDS (Figure 1C) validated the components used in the bioglass synthesis and confirmed its chlorination.…”

“…32 The peaks at 590 and 800 cm À1 corresponded to P O and SiO 4 tetrahedron, respectively. 33 The EDS spectra, as shown in Figure 1C, revealed the presence of elemental constituents specific to silicate-chlorinated BG, including sodium, calcium, phosphorus, chlorine, and silicon, within the particle structure.…”

Strontium and Zinc Co-Doped Mesoporous Bioactive Glass Nanoparticles for Potential Use in Bone Tissue Engineering Applications

“…The FTIR spectra of the particles following immersion in the SBF solution for 21 days confirmed the distinctive emergence of peaks corresponding to the formation of an HCA layer on the particle surfaces (Figure 6a). Peaks between 3200 and 3600 cm −1 , attributed to the hydroxyl groups (-OH), and between 1400 and 1600 cm −1 , attributed to carbonate groups, indicated the substitution of carbonate ions within the hydroxyapatite layer [82]. The XRD spectra of the immersed particles further validated the presence of apatite formation (Figure 6b).…”