Synthesis and in vitro assessment of anticancer hydrogels composed by carboxymethylcellulose-doxorubicin as potential transdermal delivery systems for treatment of skin cancer

Santos

Materials Science and Engineering: C

et al. 2021

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Section: J O U R N a L P R E -P R O O Fsupporting

confidence: 61%

Interaction between mucoadhesive cellulose derivatives and Pluronic F127: Investigation on the micelle structure and mucoadhesive performance

Santos

Materials Science and Engineering: C

et al. 2021

“…Recently, Carvalho et al had reported the encapsulation and release profile of the anti-cancer hydrogels composed of the carboxymethyl cellulose-doxorubicin through in vitro analysis. [67] Zhao had recently developed a novel dual functionalized supramolecular hydrogel with excellent stability, self-healing properties and biocompatibility. The reported isoguanosine-borate-guanosine based hydrogel exhibited highly anti-tumor activities and show excellent inhibition effect of tumor recurrence.…”

Section: Fabrication and Release Mechanism Of Anticancer Drug Loaded mentioning

confidence: 99%

Temperature‐Responsive Low Molecular Weight Ionic Liquid Based Gelator: An Approach to Fabricate an Anti‐Cancer Drug‐Loaded Hybrid Ionogel

et al. 2020

Conceptualising gelators with stimuli responsiveness is advantageous to design smart materials for emerging technologies. These gelators, if are surface active and made up of active pharmaceutical ingredients, can (i) exhibit an interesting pharmaceutical profile, (ii) be useful in drug formulations and (iii) exert direct effects on cell membranes. Herein, cetylpyridinium salicylate (CetPySal) that offers higher surface activity than its precursor surfactant, cetpylpyridinium chloride (CPCl), was synthesised. CetPySal forms a temperature‐responsive ionogel at a critical gelation concentration that changes its physical appearance with temperature, i. e. opaque to transparent, owing to its structural arrangement within its supramolecular framework, that are characterized through spectrometric, calorimetric, scattering and microscopic techniques. The viscoelastic nature of the ionogels was studied through dynamic rheological measurements and the interactions that governs the phase transition were studied through FTIR spectroscopy. The hybrid pharmaceutical ionogels was successfully constructed through encapsulation of the chemotherapeutic drug imatinib mesylate within the ionogel matrix. The sustained release of the drug was investigated from this hybrid ionogel matrix. These results suggest that this new thermo‐responsive ionogel may be used to improve sustained release of drugs and open up new avenues as low‐cost gelators for biomedical applications.

“…The significantly lower magnitude of systemic toxicity after MNs-based transdermal delivery may be attributed to the slow release of DOX [133]. Carvalho et al [137] evaluated the anticancer efficacy of colloidal-polysaccharide-drug nanocomplexes, made of carboxymethylcellulose (CMC)-DOX crosslinked with citric acid in a hydrogel-based formulation, using melanoma cell line (A375). The polymer-drug complex between DOX and CMC was achieved at pH 5.5, as the negatively charged carboxylate groups of CMC interacted with the positively charged amino group of DOX by strong electrostatic/ionic interactions.…”

Section: Doxorubicin Hydrochloride (Dox)mentioning

confidence: 99%

“…In contrast, when free DOX was used instead of CMC–DOX, the viability of both control and melanoma cell line was reduced. Overall, the results of this study suggest that the electrostatic complexation strategy may be used to control the cytotoxicity of cancer drugs in transdermal formulations [ 137 ].…”

Section: Transdermal Permeation Study Using Selected Chemotherapeutic Agentsmentioning

confidence: 99%

Transdermal Delivery of Chemotherapeutics: Strategies, Requirements, and Opportunities

et al. 2021

Chemotherapeutic drugs are primarily administered to cancer patients via oral or parenteral routes. The use of transdermal drug delivery could potentially be a better alternative to decrease the dose frequency and severity of adverse or toxic effects associated with oral or parenteral administration of chemotherapeutic drugs. The transdermal delivery of drugs has shown to be advantageous for the treatment of highly localized tumors in certain types of breast and skin cancers. In addition, the transdermal route can be used to deliver low-dose chemotherapeutics in a sustained manner. The transdermal route can also be utilized for vaccine design in cancer management, for example, vaccines against cervical cancer. However, the design of transdermal formulations may be challenging in terms of the conjugation chemistry of the molecules and the sustained and reproducible delivery of therapeutically efficacious doses. In this review, we discuss the nano-carrier systems, such as nanoparticles, liposomes, etc., used in recent literature to deliver chemotherapeutic agents. The advantages of transdermal route over oral and parenteral routes for popular chemotherapeutic drugs are summarized. Furthermore, we also discuss a possible in silico approach, Formulating for Efficacy™, to design transdermal formulations that would probably be economical, robust, and more efficacious.