Interaction between mucoadhesive cellulose derivatives and Pluronic F127: Investigation on the micelle structure and mucoadhesive performance

Silva, Jéssica Bassi da; Santos, Rafaela Said dos; Silva, Monique Bassi da; Braga, Gustavo; Cook, Michael T.; Bruschi, Marcos Luciano

doi:10.1016/j.msec.2020.111643

Cited by 42 publications

(21 citation statements)

References 125 publications

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“…Liquid mixtures of polymers and CNCs are often described within the framework of the depletion model, first suggested by Asakura and Oosawa 67 . Thus, as the length of the cylindrical CNCs (about 200 nm) is an order of magnitude higher than the diameter of the F127 micelles (20–25 nm), we would expect liquid–liquid phase separation 20,68,69 . If depletion interactions were important in the mixtures investigated here, we would have observed a phase separation into a rod‐rich and sphere‐rich phase (via cryo‐TEM) and crowding of the CNCs rods (reduced inter‐particle distance d 0 , in SAXS measurements).…”

Section: Discussionmentioning

confidence: 69%

“…67 Thus, as the length of the cylindrical CNCs (about 200 nm) is an order of magnitude higher than the diameter of the F127 micelles (20-25 nm), we would expect liquid-liquid phase separation. 20,68,69 If depletion interactions were important in the mixtures investigated here, we would have observed a phase separation into a rod-rich and sphererich phase (via cryo-TEM) and crowding of the CNCs rods (reduced inter-particle distance d 0 , in SAXS measurements). Neither is observed in our experiments (Figures 2, 3 and Table 3), and the measured d 0 increases in CNCs-polymer mixtures, as compared to native CNCs suspensions.…”

Section: Discussionmentioning

confidence: 89%

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Emergent hybrid mesophases in ternary mixtures of cellulose nanocrystals ‐ Pluronic micelles‐water

Cohen

Attia

Levi‐Kalisman

et al. 2022

Polymers for Advanced Techs

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Mixtures of nanometric rods and spherical micelles that are dominated by excluded volume (entropic) interactions tend to de-mix into sphere-and rod-rich mesophases.Here we report the observation of hybrid mesophases formed by mixtures of polymer-decorated sulfuric-acid-hydrolyzed cellulose nanocrystals (CNCs, rod-like particles), at high CNCs concentrations (7 wt%) where the native CNCs suspensions are at the bi-phasic (isotropic-chiral nematic) regime, and spherical micelles of the triblock-copolymers Pluronic F127 (and F108) in aqueous suspension. The polymers adsorb onto the CNCs particles, and at F127 concentrations above (10-18 wt%) the macroscopic phases of the hybrid mixture are transformed into mesoscopic droplets with a nanostructure that differs from that of the CNCs or the native Pluronics, as indicated by small-angle X-ray scattering. The observed phases preserve the chiral nematic nature of the CNCs phases with a shortened pitch, suggesting that coassembly of CNCs and self-assembling polymers may be used for engineering of emergent phases with emergent structures and properties.

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 89%

Emergent hybrid mesophases in ternary mixtures of cellulose nanocrystals ‐ Pluronic micelles‐water

Cohen

Attia

Levi‐Kalisman

et al. 2022

Polymers for Advanced Techs

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“…In addition, F127 is the most widely polymer used due to its diverse nature. Therefore, the thermo-reversible gel properties of F127 show improved retention and have major potential in pharmaceutical applications [65]. Furthermore, F127 can be used as a nano stabilizer to prevent aggregation of nanoparticles, and so on.…”

Section: Hlb (Hydrophile-lipophile Balance) 20-29 Hydrophilic Pluronicsmentioning

confidence: 99%

Polymeric Drug Delivery System Based on Pluronics for Cancer Treatment

Qiu

Yin

et al. 2021

Molecules

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Pluronic polymers (pluronics) are a unique class of synthetic triblock copolymers containing hydrophobic polypropylene oxide (PPO) and hydrophilic polyethylene oxide (PEO) arranged in the PEO-PPO-PEO manner. Due to their excellent biocompatibility and amphiphilic properties, pluronics are an ideal and promising biological material, which is widely used in drug delivery, disease diagnosis, and treatment, among other applications. Through self-assembly or in combination with other materials, pluronics can form nano carriers with different morphologies, representing a kind of multifunctional pharmaceutical excipients. In recent years, the utilization of pluronic-based multi-functional drug carriers in tumor treatment has become widespread, and various responsive drug carriers are designed according to the characteristics of the tumor microenvironment, resulting in major progress in tumor therapy. This review introduces the specific role of pluronic-based polymer drug delivery systems in tumor therapy, focusing on their physical and chemical properties as well as the design aspects of pluronic polymers. Finally, using newer literature reports, this review provides insights into the future potential and challenges posed by different pluronic-based polymer drug delivery systems in tumor therapy.

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“…Above the critical micelle concentration (cmc), as temperature increases, the copolymer undergoes self-assembling forming a micellar structure, that spontaneously organizes into a shear-thinning, thermoreversible network [ 4 , 6 , 8 , 11 ]. The micellization and gelation processes, as well as the shape adopted by PL micelles (globular, cubic, or hexagonal), depend on thermodynamic conditions (solvent, temperature) and they are influenced by the addition of other pharmaceutical excipients or drug molecules [ 1 , 12 , 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Temperature Induced Gelation and Antimicrobial Properties of Pluronic F127 Based Systems

Lupu¹,

Roșca²,

Gradinaru

et al. 2023

Polymers

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Different formulations containing Pluronic F127 and polysaccharides (chitosan, sodium alginate, gellan gum, and κ-carrageenan) were investigated as potential injectable gels that behave as free-flowing liquid with reduced viscosity at low temperatures and displayed solid-like properties at 37 °C. In addition, ZnO nanoparticles, lysozyme, or curcumin were added for testing the antimicrobial properties of the thermal-sensitive gels. Rheological investigations evidenced small changes in transition temperature and kinetics of gelation at 37 °C in presence of polysaccharides. However, the gel formation is very delayed in the presence of curcumin. The antimicrobial properties of Pluronic F127 gels are very modest even by adding chitosan, lysozyme, or ZnO nanoparticles. A remarkable enhancement of antimicrobial activity was observed in the presence of curcumin. Chitosan addition to Pluronic/curcumin systems improves their viscoelasticity, antimicrobial activity, and stability in time. The balance between viscoelastic and antimicrobial characteristics needs to be considered in the formulation of Pluronic F127 gels suitable for biomedical and pharmaceutical applications.

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Interaction between mucoadhesive cellulose derivatives and Pluronic F127: Investigation on the micelle structure and mucoadhesive performance

Cited by 42 publications

References 125 publications

Emergent hybrid mesophases in ternary mixtures of cellulose nanocrystals ‐ Pluronic micelles‐water

Emergent hybrid mesophases in ternary mixtures of cellulose nanocrystals ‐ Pluronic micelles‐water

Polymeric Drug Delivery System Based on Pluronics for Cancer Treatment

Temperature Induced Gelation and Antimicrobial Properties of Pluronic F127 Based Systems

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