Synthesis and Fundamental Characterization of Diverse Properties of Biocompatible Cd (II) Phosphor Complex for Cytotoxic Activity and Latent Fingerprint Detection

Abstract

The development of biocompatible fluorescent materials based on CdII (d10) systems for cytotoxic application and latent fingerprint detection under UV illumination has not yet been studied that thoroughly. In this sense, this work presents production of novel and dual nature pure Cd (II) phosphor complex based on ρ‐dimethylaminobenzaldehyde thiosemicarbazone ligand (H‐DMABTS). The structural characterization confirms that the ligand which acts as monoanionic bidentate through NS donor sites, forming mononuclear complex formulates as: [Cd (DMABTS)2(C2H5OH)2] where, DMABTS = anionic form of ρ‐dimethylaminobenzaldehyde thiosemicarbazone. TEM analysis shows that Cd (II) complex has sheet like shape in micro scale. Moreover, the Cd (II) complex was dispersed into silica host. Photoluminescence emission and lifetime of H‐DMABTS ligand, Cd (II) complex and Cd (II) complex dispersied into silica were measured. Cd (II) complex is intensive luminescent with impressive visual emission under UV excitation. All fluorescent materials were tested for their in vitro cytotoxicity against HepG‐2 cell line. The Cd (II) phosphor complex shows higher activity (IC50 = 0.005 μM) than other prepared materials and different standard antitumor drugs. Furthermore, the Cd (II) phosphor complex has a lower toxicity value (LD50 = 130 mg/Kg) relative to the standard cis‐platin (LD50 = 13.5 mg/Kg). Moreover, latent prints details, including their characteristic three levels, have been clearly identified from various forensic substrates (non‐porous, semi‐porous, porous) using Cd (II) phosphor complex.

Novel electrospun fibers as carriers for delivering a biocompatible Sm(iii) nanodrug for cancer therapy: fabrication, characterization, cytotoxicity and toxicity

“…These results have indicated that pure Sm(III) nanocomplex and its ber are less toxic with respect to standard cis-platin (LD 50 = 13.5 mg kg −1 ). 51,52 The lowest toxicity with the highest cytotoxicity of electrospun Sm(III) ber makes it a promising biocompatible antitumor agent impeded in polymeric delivery host to help in using it as a biocompatible agent for drug delivery.…”

Co(ii), Ni(ii), Cu(ii) and Cd(ii)-thiocarbonohydrazone complexes: spectroscopic, DFT, thermal, and electrical conductivity studies

“…It was thought from rst sight that these shis could indicate the bonding of the unsaturated nitrogen of the azomethine group and thione-sulfur towards the metal ion. [51][52][53] The presence of new bands due to n(M ) N) is at 470-478 cm À1 is another obvious sign of the participation of nitrogen atom of the azomethine group in the coordination. [54][55][56] The IR spectral data of the Co(II), Ni(II), and Cu(II) complexes show new bands at 3424-3440 cm À1 correlating to the overlap with lattice and/or coordinated water.…”

Novel thiosemicarbazone complexes as anticancer agents: Synthesis, characterization, cytotoxicity, docking, and density functional theory studies

“…The disappearance of the (NH) band in the spectra of DABT complexes is evidence for the existence of DABT in the enol form in addition to the appearance of a new (C=N) band, which confirmed this suggestion. The IR bands at 1590 and (1367, 873) cm −1 attributed to stretching vibration of the (CH=N) and (C—S) groups, respectively, in the free DABT were detected at lower frequency in DABT– Co (II), Ni (II) and Cu (II) complexes, indicated the coordination of N and S of azomethine and thiol groups, respectively 34,35 . Also, new bands appeared in the range of (485–465 cm −1 ) owing to stretching vibration of (M—N) 36 .…”