Novel thiosemicarbazone complexes as anticancer agents: Synthesis, characterization, cytotoxicity, docking, and density functional theory studies
Amira A. M. Ali,
Rania Fouad
Abstract:New Co (II), Ni (II), and Cu (II) complexes based on ρ‐dimethylaminobenzaldehyde thiosemicarbazone (DABT) as chelating agents were synthesized. The structure of the three complexes was determined by elemental analysis and TGA with IR, UV–Vis, XRD, ESR spectra, conductivity, and magnetic measurements. It was found that the isolated DABT complexes have tetrahedral structure with a neutral nature. The antitumor activity of DABT complexes using viability assay was examined against hepatocellular carcinoma cell lin… Show more
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