Novel electrospun fibers as carriers for delivering a biocompatible Sm(iii) nanodrug for cancer therapy: fabrication, characterization, cytotoxicity and toxicity

Abstract

The current study represents the successful fabrication and characterization of a Sm(iii) nano complex based on 2-cyano-N′-((4-oxo-4H-chromen-3-yl)methylene)acetohydrazide (CCMA).

Dual function of new Nd(III) and Gd(III) complexes for cytotoxic and optoelectronic fields: Synthesis, characterization, DFT calculations, and PVA composite films

“…Inhibiting the reductase thioredoxin and targeting the pathway of the glutathioneindependent lipoate reduction using gadolinium (III) texaphyrin (MGd, Xcytrin) is the other important mechanism that, subsequently inhibits the replication of cancer cells in DNA, repairs and induces oxidative stress. 37 The variance of reactivity between the Nd(III) and Gd(III) complexes confirms the experimental and the theoretical energy gab data (see sections 3.5 and 3.6).…”

“…The infrared spectral data of obtained Nd(III) and Gd(III) complexes and their chelating agent ( CA ) with their tentative assignments are tabulated in Table 2. The free chelating agent ( CA ) exhibited characteristic vibration bands of (C=O) amide , (C=O) γ‐pyrane and (C=N) azomethine groups, which are shifted in Nd(III) and Gd(III) complexes spectral bands, indicating the participation of these groups in the chelation 37,38 . The participation of these groups is confirmed by the appearance of new vibration bands at (576–547) and (469–444) cm −1 , which are assigned to (M‐O) and (M‐N) frequencies 38,39 .…”

“…The free chelating agent (CA) exhibited characteristic vibration bands of (C=O) amide , (C=O) γ-pyrane and (C=N) azomethine groups, which are shifted in Nd(III) and Gd(III) complexes spectral bands, indicating the participation of these groups in the chelation. 37,38 The participation of these groups is confirmed by the appearance of new vibration bands at (576-547) and (469-444) cm À1 , which are assigned to (M-O) and (M-N) frequencies. 38,39 New vibration bands observed at (1,243 and 1,031) cm À1 in the case of Nd(III) complex confirmed the presence of a coordinated nitrate group.…”

Novel thiosemicarbazone complexes as anticancer agents: Synthesis, characterization, cytotoxicity, docking, and density functional theory studies

“…The detected IC 50 (μM) was 13.4, 12.0, and 27. 47 Besides, DABT-Ni (II) has higher activity than the other DABT complexes.…”

Synthesis, structural, spectroscopic and electric/dielectric studies of a nanocrystalline Ni(ii) complex based on [(1,3-diphenyl-1H-pyrazol-4-yl)methylene]thiocarbonohydrazide

“…The other band that appeared as a shoulder at 370 nm could be attributed to the p-p* transitions within the aromatic rings. 38,39 In the UV-Vis spectrum of Ni(PyT), the bands of the intraligand were shied to a higher wavelength. This behavior implies that the metal ions coordinate with nitrogen and/or sulfur.…”