Synthesis and Evaluation the Activity of 1,3,4-Thiadiazole Derivatives as Antibacterial Agent Against Uncommon Bacteria Causes of Urinary Tract Infections

Abstract

Schiff base compound 5-(benzylideneamino)-1,3,4-thiadiazole-2-thiol was prepared from condensation reaction of 2-amino-5-mercapto-1,3,4-thiadiazole with benzaldehyde. New Schiff bases react with copper (II), Ferric (III), Cobalt (II) and Zinc (II) to form four complexes. The Schiff base complexes were identification by using FTIR and UV-VIS. The antibacterial activity of complexes (Copper (II) LM 1 , Ferric (III) LM 2 , Cobalt (II) LM 3 and Zinc (II) LM 4 complexes) were studied against Kocuria kristinae, Alloiococcus otiti and Aerococcus urinae as a model of Gram positive, Pseudomonas stutzeri, Ochrobactrum anthropic and Pantoea agglomerans as a model of Gram negative to determine the activity of synthesized complexes. Identification of these uncommon bacteria that isolated from urinary tract infection confirmed by using VITEK2 compact system. Several antibiotics have been chosen to investigate the ability of these isolates to resist the conventional antibiotic. The results showed higher activity of the new compounds relative to the chosen antibiotics.

Determination of some virulence factors of Citrobacter freundii isolated from Iraqi patients

“…Resistance to broadspectrum cephalosporins (third and fourth generation) is achieved through diminishing permeability through the outer membrane, higher production of AmpC β-lactamase enzymes, acquisition of plasmids, or the combination of these factors together. The results of the present study are in accordance to those of a previous study [29], which showed the susceptibility of some Gram negative bacteria to 24 antibiotics. The authors found that most of the isolates were highly resistant to most of the antibiotics, which may be due to the production of β-lactamase.…”