Synthesis and Evaluation of Novel Glass Ceramics as Drug Delivery Systems in Osteomyelitis

Thanyaphoo, Suphannee; Kaewsrichan, Jasadee

doi:10.1002/jps.23230

Cited by 26 publications

(20 citation statements)

References 40 publications

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“…For example, it is biocompatible and bone cells can grow and infiltrate its surface. In matrix form it can deliver vancomycin with tunable release kinetics in vitro [9]. In this study, we simultaneously loaded vancomycin and BMP-2 into a single graft composing of Si-nHA particles.…”

Section: Discussionmentioning

confidence: 99%

“…There was a decrease of infection when the antibiotic was included in the scaffolds. This might be the result of the higher burst effect that plays an active role in eradicating the pathogen in the contaminated wound at early stages, followed by sustained release of the antibiotic at an effective dose to ensure protection of the implanted grafts from colonization by remaining bacteria [9,11]. A small number of neutrophils were found along the scaffold boundaries, suggesting a mild foreign body reaction.…”

Section: Discussionmentioning

confidence: 99%

“…For effective treatment of open fractures and osteomyelitis by diminishing the systemic toxicity of the antibiotic, problems relating to protein instability, and rapid clearance after in vivo bolus administration, it is necessary to develop advanced vehicles for the sustained local release of antibiotics. Carrier systems containing vancomycin have been created and their efficacy has been assessed in vitro [9]. In this study, we integrated BMP-2 and vancomycin into a single matrix that conveys both these treatment strategies.…”

Section: Brief Communication (Original)mentioning

confidence: 99%

“…Three types of implants were designed ( Figure 1) and prepared using methods previously described [9]. Vancomycin and BMP-2 at concentrations of 100 mg mL −1 and 5 μg mL…”

Section: Implant Design and Fabrication And Loading Of Vancomycin Anmentioning

confidence: 99%

“…respectively were separately loaded onto half of each implant [9]. The prepared implants were stored at 4°C until use.…”

Section: Implant Design and Fabrication And Loading Of Vancomycin Anmentioning

confidence: 99%

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Potential of bone scaffolds containing vancomycin and bone morphogenetic protein-2 in a rat model of osteomyelitis

Thanyaphoo

Kaewsrichan

2014

Asian Biomedicine

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Background: Infected bone is often intractable. An ideal approach is to simultaneously eradicate infection and repair the bone defect. The development of osteoinductive bone graft composites to control antibiotic drug release would be useful for the treatment of intractable bone infections. Objectives: To develop a rat model of osteomyelitis for assessing osteoinductive bone graft scaffolds containing antibiotics and a bone morphogenetic protein.Methods: Si-imprinted calcium phosphate is a new hydroxyapatite derivative used in fabricating bone scaffolds. Vancomycin and bone morphogenetic protein-2 (BMP-2) were loaded onto scaffolds of Si-imprinted calcium phosphate using an established method. The efficiency of the scaffold as a drug carrier system was assessed in vivo. Osteomyelitis was induced in rats by infection of the tibial epiphysis with Staphylococcus aureus (BAA 1680). The success of inducing disease was checked after 4 weeks using bacterial culture and radiography. A 10 mm metaphysis bone was surgically removed and replaced with a drug-loaded scaffold. Histology and X-ray imaging were used to evaluate the implants at 8 weeks post implantation. Results: We successfully established a rat model of osteomyelitis. The causative bacteria were effectively eradicated by vancomycin released from the implants. Enhanced bone formation was observed for the implant samples containing vancomycin and BMP-2 compared with those containing either vancomycin or BMP2 alone. Conclusions:The newly developed bone scaffold has potential as a vehicle for therapeutic agents to treat bone diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Brief Communication (Original)mentioning

confidence: 99%

“…Three types of implants were designed ( Figure 1) and prepared using methods previously described [9]. Vancomycin and BMP-2 at concentrations of 100 mg mL −1 and 5 μg mL…”

Section: Implant Design and Fabrication And Loading Of Vancomycin Anmentioning

confidence: 99%

“…respectively were separately loaded onto half of each implant [9]. The prepared implants were stored at 4°C until use.…”

Section: Implant Design and Fabrication And Loading Of Vancomycin Anmentioning

confidence: 99%

See 3 more Smart Citations

Potential of bone scaffolds containing vancomycin and bone morphogenetic protein-2 in a rat model of osteomyelitis

Thanyaphoo

Kaewsrichan

2014

Asian Biomedicine

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Implantable Materials for Local Drug Delivery in Bone Regeneration

Díaz‐Rodríguez

Landín

2016

Advanced Materials Interfaces

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Improvement of drug elution in thin mineralized collagen coatings with PLGA‐PEG‐PLGA micelles

Ling

Weng

et al. 2013

J Biomedical Materials Res

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A mineralized collagen (MC) coating on metallic implants has shown great potential as orthopedic material due to high biological responses. However, their drug delivery capacity remains unsatisfactory since a serious burst release may occur and long-term release is hard to be achieved. Aiming to improve the drug-eluting capability, we incorporated drug-loaded PLGA-PEG-PLGA (PPP) micelles into the thin coating. The in vitro release profiles showed that the burst release in the initial 8 h of the modified coating decreased from 81% to 58% compared to MC coating alone; meanwhile, the release duration was prolonged from 3 days to 1 week. Additionally, the release kinetics of vancomycin hydrochloride (VH, the model drug) could be adjusted by changing the size and concentration of PPP micelles. Interestingly, less initial release of VH caused by micelle immobilization did not affect the antibacterial activity in the early stage of implantation according to the antimicrobial test. The cytocompatibility assay demonstrated that the VH-loaded PPP micelles did not have negative effect on the bioactivity of coating which greatly enhanced cell activity compared to bare Ti substrates. Thus, the MC coatings with PPP micelles could be an effective implant route for bone repair.

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Synthesis and Evaluation of Novel Glass Ceramics as Drug Delivery Systems in Osteomyelitis

Cited by 26 publications

References 40 publications

Potential of bone scaffolds containing vancomycin and bone morphogenetic protein-2 in a rat model of osteomyelitis

Potential of bone scaffolds containing vancomycin and bone morphogenetic protein-2 in a rat model of osteomyelitis

Implantable Materials for Local Drug Delivery in Bone Regeneration

Improvement of drug elution in thin mineralized collagen coatings with PLGA‐PEG‐PLGA micelles

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