Implantable Materials for Local Drug Delivery in Bone Regeneration

Díaz‐Rodríguez, Patricia; Landín, Mariana

doi:10.1002/9781119242604.ch9

Cited by 2 publications

(2 citation statements)

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“…Therapeutic molecules can be trapped into the structure of bioceramics or bioceramic-based composites during their synthesis, or in subsequent processes. The homogenization of the drug inside the scaffold matrix is an important factor to avoid the burst release while drug release rate is conditioned by drug diffusion and scaffold resorption [13].…”

Section: Biomimetic Ceramics As Drug Delivery Platformsmentioning

confidence: 99%

“…From the chemical point of view, bone is considered a nanocomposite of an inorganic phase nanocrystalline carbonated apatite and an organic phase (collagen, glycoproteins, and mucopolysaccharides). These bone features allow for the body mobility, support, and protection of the organs [10,11,12,13]. Furthermore, bone is the second most transplanted tissue, just after blood, and despite the huge advances on the development of biomaterials able to restore or replace it, no perfect materials has been obtained [9,14].…”

Section: Introductionmentioning

confidence: 99%

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Drug-Loaded Biomimetic Ceramics for Tissue Engineering

Díaz‐Rodríguez

Sánchez

2018

Pharmaceutics

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The mimesis of biological systems has been demonstrated to be an adequate approach to obtain tissue engineering scaffolds able to promote cell attachment, proliferation, and differentiation abilities similar to those of autologous tissues. Bioceramics are commonly used for this purpose due to their similarities to the mineral component of hard tissues as bone. Furthermore, biomimetic scaffolds are frequently loaded with diverse therapeutic molecules to enhance their biological performance, leading to final products with advanced functionalities. In this review, we aim to describe the already developed bioceramic-based biomimetic systems for drug loading and local controlled release. We will discuss the mechanisms used for the inclusion of therapeutic molecules on the designed systems, paying special attention to the identification of critical parameters that modulate drug loading and release kinetics on these scaffolds.

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Section: Biomimetic Ceramics As Drug Delivery Platformsmentioning

confidence: 99%