Synthesis and enzymatic degradation of regular network aliphatic polyesters

Characterization of the prepolymer and gel of biocompatible poly(xylitol sebacate) in comparison with poly(glycerol sebacate) using a combination of mass spectrometry and nuclear magnetic resonance

“…Nagata et al 7,8 used infrared spectroscopy to estimate the extent of esterification in copolymers of glycerol with a series of aliphatic dicarboxylic acids and related this to their physical and mechanical properties and the rate of alkaline and enzymatic hydrolysis. Liu et al 9 presented the 1 H NMR spectrum of a low-molecular-weight PGS prepolymer and characterized the swelling, thermal behaviour and mechanical properties of its crosslinked gel.…”

Synthesis, characterization, and enzymatic degradation of network aliphatic copolyesters

“…Biodegradable network copolyesters were prepared from glycerol (Yg) and sebacic acid (10) with succinic acid (4), 1,12-dodecanedicarboxylic acid (14), 1,18-octadecanedicarboxylic acid (20), or terephthalic acid (T). The enzymatic degradation rate of Yg10 was rapidly reduced with increasing 4, 20, and T comonomer contents and the weight loss was hardly observed for the Yg-10/4, Yg-10/20, and Yg-10/T films at the composition of more than 50 mol % comonomers.…”

“…Succinic acid (4), sebacic acid (10), 1,12-dodecanedicarboxylic acid (14), 1,18-octadecanedicarboxylic acid (20), and dimethyl terephthalate (T) were used as received. Glycerol (Yg) was distilled under reduced pressure.…”

“…The incorporation of network structure into the polymer backbone is also expected to give better physical and chemical properties such as resistance to heat distortion and resistance to chemicals. [13][14][15][16][17][18][19] In previous papers, 20,21 we reported that network polyester films prepared from aliphatic dicarboxylic acids with medium methylene chain length (C 8 -C 12 ) and glycerol (Yg) were degraded markedly by lipase enzymes. Above all, a Yg10 film from sebacic acid and Yg lost about 60% of its original weight after incubation in a Rhizopus delemar lipase buffer solution for 2 h at 37°C.…”

Synthesis and Enzymatic Degradation of Soft Aliphatic Polyesters

“…[11][12][13][14][15][16][17][18] The enzymatic degradation of other poly(adipates) were analyzed in detail by Gan et al [12] The degradation behavior depended on the crystallinity, the crystal size and the crystal structure, which influenced the degradation rate and resulting morphological changes. The occurrence of sheaf-like structures and holes on the surface after treating the polymer film with enzymatic solutions corresponds to the crystal structure of the films, which is, in turn, highly dependent on the crystallization temperature and tempering conditions.…”