Synthesis and dissolution behavior of β-TCP and HA/β-TCP composite powders

Kwon, Soonho; Jun, Youn-Ki; Hong, Seong‐Hyeon; Kim, Hyoun‐Ee

doi:10.1016/s0955-2219(02)00263-7

Cited by 263 publications

(136 citation statements)

References 16 publications

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“…(3) are monetite and HA. In other words, this work confirms the conclusion of previous studies [9,17] which stated that β-TCP cannot be precipitated directly from an aqueous solution.…”

Section: Phases Formed As a Consequence Of Variable Stirring Speedssupporting

confidence: 92%

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Parameters affecting the synthesis of -tricalcium phosphate powder using a wet precipitation method

Othman¹,

Mustafa²,

Kiên³

et al. 2017

J. MECH. ENG. SCI.

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In this work, precursor materials that are normally used to directly synthesise hydroxyapatite (HA) were adopted to obtain tricalcium phosphate (TCP). Calcium hydroxide, (Ca(OH)2), and phosphoric acid, (H3PO4), with a Ca/P ratio of 1.5, were mixed as the precursor materials. The mixture was stirred at various stirring speeds ranging from 0 to 400 rpm, over a range of stirring durations of 1 to 4 hours. Upon completion of the reaction, the as-prepared powders were calcined at different temperatures ranging from 500 o C-1300 o C for a soaking duration that was varied between 1-4 hours. Differential scanning calorimetry (DSC) and thermogravimetry (TG) were used for thermal analyses to ascertain the calcination temperatures, whilst x-ray diffraction (XRD) was utilised to determine the phases formed before and after calcination. Field emission scanning electron microscopy (FESEM) was used to monitor the morphological changes at different calcination temperatures. Based on the XRD results, the phases formed were dependent on the processing parameters employed. This work has successfully ascertained that the most optimum parameters to synthesise singlephase β-TCP are a stirring speed of 200 rpm, a calcination temperature of 900 o C, a calcination soaking duration of 2 hours and a mixing duration of 1 hour. Microstructural observation conducted on the -TCP powders obtained at calcination temperatures of 900 o C to 1300 o C showed an aggregated structure of particles with massive grain growth as the temperature was raised up to 1300 o C.

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“…(3) are monetite and HA. In other words, this work confirms the conclusion of previous studies [9,17] which stated that β-TCP cannot be precipitated directly from an aqueous solution.…”

Section: Phases Formed As a Consequence Of Variable Stirring Speedssupporting

confidence: 92%

“…The solid-state reaction was reported by several researchers [3][4][5], whilst the wet chemical reaction was carried out in a handful of studies [6][7][8][9]. However, these synthesised β-TCP powders were not stable in terms of its thermal properties whereby they were converted to α-TCP at temperatures above 1125 o C [5].…”

Section: Introductionmentioning

confidence: 99%

Parameters affecting the synthesis of -tricalcium phosphate powder using a wet precipitation method

Othman¹,

Mustafa²,

Kiên³

et al. 2017

J. MECH. ENG. SCI.

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“…This phenomenon motivated the development of BCP and bio-glasses which have tunable (to some degree) degradation rates based on the relative magnitude of TCP (more commonly b-TCP) and HAp in a composite ceramic. [127][128][129][130][131] To mimic the physical attributes of bone, synthetic scaffolds must have a high degree of porosity. When ceramics such as TCP, HAp, and BCP are formed into porous scaffolds, the macroscopic mechanical properties are inadequate for load bearing surfaces due to the inherent brittleness of the ceramics.…”

Section: Bone Biomimeticsmentioning

confidence: 99%

“…rate. 123,129,130,140,147 However, these materials hold little clinical utility due to their poor mechanical properties discussed above. Natural polymers such as collagen, fibrin, alginate, gelatin, and GAGs have also been extensively investigated as drug delivery vehicles in bone tissue engineering.…”

Section: Localized Bioactive Molecule and Drug Delivery In Bone Repairmentioning

confidence: 99%

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Porter

Ruckh

Popat

2009

Biotechnology Progress

676

499

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Critical‐sized defects in bone, whether induced by primary tumor resection, trauma, or selective surgery have in many cases presented insurmountable challenges to the current gold standard treatment for bone repair. The primary purpose of a tissue‐engineered scaffold is to use engineering principles to incite and promote the natural healing process of bone which does not occur in critical‐sized defects. A synthetic bone scaffold must be biocompatible, biodegradable to allow native tissue integration, and mimic the multidimensional hierarchical structure of native bone. In addition to being physically and chemically biomimetic, an ideal scaffold is capable of eluting bioactive molecules (e.g., BMPs, TGF‐βs, etc., to accelerate extracellular matrix production and tissue integration) or drugs (e.g., antibiotics, cisplatin, etc., to prevent undesired biological response such as sepsis or cancer recurrence) in a temporally and spatially controlled manner. Various biomaterials including ceramics, metals, polymers, and composites have been investigated for their potential as bone scaffold materials. However, due to their tunable physiochemical properties, biocompatibility, and controllable biodegradability, polymers have emerged as the principal material in bone tissue engineering. This article briefly reviews the physiological and anatomical characteristics of native bone, describes key technologies in mimicking the physical and chemical environment of bone using synthetic materials, and provides an overview of local drug delivery as it pertains to bone tissue engineering is included. © 2009 American Institute of Chemical Engineers Biotechnol. Prog., 2009

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“…Kwon ve ark. çalışmalarında da belirttikleri gibi pH değerinin artması sonucunda Ca/P oranıda artmakta bunun sonucunda bifazik malzemeler ortaya çıkmaktadır [17]. 7 Önceki çalışmalar, β-TCP'nin çöktürme yöntemiyle direk olarak sentezlenemeyeceğini göstermişlerdir [7].…”

Section: Bulgular Ve Tartişma (Results and Discussion)unclassified

Flor İyonlari İlave Edi̇lmi̇ş Nano-Kalsi̇yum Fosfatlarin Mi̇kroyapisinin Araştirilmasi

Tahmasebifar¹,

Güngör²,

Evis³

2015

Gazi Üniversitesi Mühendislik-Mimarlık Fakültesi Dergisi

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ÖZETBu çalışmada, farklı kompozisyonlarda flor (F -) iyonları ilave edilmiş kalsiyum fosfatlar (CaP) çöktürme yöntemi ile üretilmiş ve mikroyapılarını incelemek için 1100ºC'de 1 ve 5 saat sinterlenmiştir. Sinterleme zamanının uzatılması ile sinterlenmiş malzemelerin yoğunluklarının arttığı gözlemlenmiştir. Ana faz olarak β-üç kalsiyum fosfatın (TCP) varlığı Rietveld yöntemi tarafından belirlenen yapısal analizlerle belirlenmiştir. Ayrıca örneklerde önemli miktarda hidroksiapatit (HA) tespit edilmiştir. İyonların ilave edilmesiyle birim kafes hacmi küçülmüştür. Taramalı elektron mikroskobu (SEM) sonuçları, iyonların eklenmesiyle daha küçük tanelerin oluştuğunu göstermiştir. Fourier dönüşümlü kızıl ötesi spektrometresi (FTIR), karakteristik TCP bantlarına ek olarak, F -iyonunun varlığını doğrulamıştır.Anahtar Kelimeler: Biyoseramikler; kalsiyum fosfatlar; katkılama; sinterleme THE MICRO-STRUCTURAL INVESTIGATION OF NANO-CALCIUM PHOSPHATES DOPED WITH FLUORIDE IONS ABSTRACTIn this study, fluoride (F -) doped calcium-phosphates (CaP) at various compositions were synthesized by a precipitation method and sintered at 1100ºC for 1 and 5 h to investigate their microstructures. It was observed that densities of the sintered materials were increased by extending the sintering time. The structural analysis determined by Rietveld refinement proved the presence of β-tri-calcium phosphate (TCP) as the main phase. Also, a considerable amount of hydroxyapatite (HA) was detected in the samples. Unit cell volumes shrinked upon ions substitution. Scanning electron microscopy (SEM) results showed that addition of doping ions resulted in smaller grains. In Fourier transform infrared spectroscopy (FTIR), in addition to the characteristic bands of TCP, F -ion substitution was confirmed.

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Synthesis and dissolution behavior of β-TCP and HA/β-TCP composite powders

Cited by 263 publications

References 16 publications

Parameters affecting the synthesis of -tricalcium phosphate powder using a wet precipitation method

Parameters affecting the synthesis of -tricalcium phosphate powder using a wet precipitation method

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Flor İyonlari İlave Edi̇lmi̇ş Nano-Kalsi̇yum Fosfatlarin Mi̇kroyapisinin Araştirilmasi

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