Synthesis and crystal structure of Cu(II) and Co(II) complexes with 1,3-dimethyl-pyrazole-5-carboxylic acid ligand

Abstract

In the reaction of 1,3-dimethyl-pyrazole-5-carboxylic acid (HL) with M(OAc)2?4H2O, (M = Cu, Co) two novel complexes have been prepared, square-planar [CuL2(H2O)2] and octahedral [CoL2(MeOH)4]. The crystal structures have been determined by single-crystal X-ray diffraction. In both complexes the deprotonated acid displays monodentate coordination to the metal ions. According to the results of CSD survey this is the first structural report on the metal complexes with N1-substituted pyrazole-5-carboxylic ligand. [Projekat Ministarstva nauke Republike Srbije, br. 172014 i br. 172035]

Synthesis, crystal structure and biological activity of copper(II) complex with 4-nitro-3-pyrazolecarboxylic ligand

“…10 These compounds are rare examples of the metal complexes comprising 3,4-disubstituted pz derivative as a bridge and also the first crystal structures of the transition metal complexes with ligands derived from 4-nitro-3-pyrazolecarboxylic acid (Scheme 1a). Continuing our interest in pyrazole-derived molecules, [10][11][12] and particularly the bridging and structural behaviour of 4-nitro-3-pyrazolecarboxylate ligand 10,11 we have synthesized a new binuclear complex [Cu2(4nitro-3pzc)2(H2O)6]2H2O, Scheme 1b. The Cu(II) ion, is here found in the tetragonally distorted octahedral environment, dissimilar to previously reported five-coordinated Cu(II) complex with the same ligand.…”

Anticancer and antimicrobial properties of novel η6-p-cymene ruthenium(ii) complexes containing a N,S-type ligand, their structural and theoretical characterization

“…Moreover, they are applied as dyes and agrochemicals. [12][13][14][15][16] So far, scientic interest has been focused mainly on the anticancer activity of the complexes of pyrazole carbothioamide derivatives with various metal ions, e.g. Cu(II), Zn(II), Co(II) and Ni(II) against HL-60, NALM-6, WM-15 and HUVECs cell lines.…”