Synthesis and characterization of zinc oxide nanoparticles by using polyol chemistry for their antimicrobial and antibiofilm activity

Mahamuni, Pranjali P.; Patil, Pooja; Dhanavade, Maruti J.; Badiger, Manohar V.; Shadija, Prem G.; Lokhande, A.C.; Bohara, Raghvendra A.

doi:10.1016/j.bbrep.2018.11.007

Cited by 139 publications

(78 citation statements)

References 58 publications

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“…In comparison to the average absorption at 377 nm of ZnO NPs, the synthesized LB-ZnO NPs with a maximum wavelength at 373.82 nm were slightly blue-shifted which maybe because of the decrease in particle size with respect to bulk ZnO [47]. Mahamuni et al [48] and Ishwarya et al [49] reported a similar shift in the position of the absorption peak of ZnO NPs. Figure 1b shows the optical energy bandgap (Eg) of LB-ZnO NPs which was estimated using the following Tauc formula [50].…”

Section: Uv-visible Spectroscopymentioning

confidence: 78%

Eco-friendly approach to control dengue vector Aedes aegypti larvae with their enzyme modulation by Lumnitzera racemosa fabricated zinc oxide nanorods

Dhavan

Jadhav

2020

SN Appl. Sci.

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Aedes aegypti mosquito species is a primary vector for dengue, chikungunya and Zika infections, and vector control is the only key approach for reducing their transmission. The present study emphasizes on environmental friendly approach for the fabrication of zinc oxide nanorods (ZnO NRs) using aqueous extract of Lumnitzera racemosa flower buds (LB) as a reducing and stabilizing agent. ZnO NRs were examined by UV-Vis spectroscopy with characteristic absorbance band at 373.82 nm and bandgap of 3.25 eV. FT-IR analysis revealed the functional groups associated with ZnO NRs. The crystallinity of LB-ZnO NRs was further investigated using X-ray diffraction. The Zeta potential displayed a surface charge of − 23.5 mV on NRs. Energy dispersive spectra analysis and SEM analysis confirmed the formation of ZnO NRs whilst TEM highlighted the average length and diameter in the range of 250-300 nm and 45-50 nm respectively. LB-ZnO NRs were found to be efficacious against Ae. aegypti 4th instar larvae with LC 50 of 24.74 μg/ml. Decreased acetylcholinesterase (60.6%) and glutathione S-transferase (24.4%) activities were also evaluated in Ae. aegypti larvae which were exposed to synthesized LB-ZnO NRs with no genetic aberrations. All these outcomes propose the potential employment of LB-ZnO NRs in mosquito control, as well as an effective alternative to insecticide resistance.

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Section: Uv-visible Spectroscopymentioning

confidence: 78%

Eco-friendly approach to control dengue vector Aedes aegypti larvae with their enzyme modulation by Lumnitzera racemosa fabricated zinc oxide nanorods

Dhavan

Jadhav

2020

SN Appl. Sci.

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“…In the present study, a notable mean inhibitory capacity of ZnO NPs (99.73%) was observed. According to Mahamuni et al, ZnO nanoparticles exhibited significant percentages of S. aureus biofilm inhibition, proving its usage as a potential antibiofilm agent in the biomedical application [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Promising Antibiofilm Agents: Recent Breakthrough against Biofilm Producing Methicillin-Resistant Staphylococcus aureus

El-Hamid

El-Naenaeey

Kandeel³

et al. 2020

Antibiotics

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Multidrug resistant (MDR) methicillin-resistant Staphylococcus aureus (MRSA) is a superbug pathogen that causes serious diseases. One of the main reasons for the lack of the effectiveness of antibiotic therapy against infections caused by this resistant pathogen is the recalcitrant nature of MRSA biofilms, which results in an increasingly serious situation worldwide. Consequently, the development of innovative biofilm inhibitors is urgently needed to control the biofilm formation by this pathogen. In this work, we thus sought to evaluate the biofilm inhibiting ability of some promising antibiofilm agents such as zinc oxide nanoparticles (Zno NPs), proteinase K, and hamamelitannin (HAM) in managing the MRSA biofilms. Different phenotypic and genotypic methods were used to identify the biofilm producing MDR MRSA isolates and the antibiofilm/antimicrobial activities of the used promising agents. Our study demonstrated strong antibiofilm activities of ZnO NPs, proteinase K, and HAM against MRSA biofilms along with their transcriptional modulation of biofilm (intercellular adhesion A, icaA) and quorum sensing (QS) (agr) genes. Interestingly, only ZnO NPs showed a powerful antimicrobial activity against this pathogen. Collectively, we observed overall positive correlations between the biofilm production and the antimicrobial resistance/agr genotypes II and IV. Meanwhile, there was no significant correlation between the toxin genes and the biofilm production. The ZnO NPs were recommended to be used alone as potent antimicrobial and antibiofilm agents against MDR MRSA and their biofilm-associated diseases. On the other hand, proteinase-K and HAM can be co-administrated with other antimicrobial agents to manage such types of infections.

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“…A smaller size corresponds to a larger specific surface area and smaller volume, thus enhancing Zn 2+ dissolution, ROS generation, and abilities to adsorb and penetrate cell membranes. 65,[73][74][75][76] Mahamuni et al 77 obtained ZnO-NPs with a diameter range of 15-100 nm through polyol synthesis. ZnO-NPs with the smallest diameter of 15 nm showed the best antibacterial effect on Staphylococcus aureus.…”

Section: Antibacterial Properties Of Zno-nps Antibacterial Mechanism mentioning

confidence: 99%

<p>Enhancing ZnO-NP Antibacterial and Osteogenesis Properties in Orthopedic Applications: A Review</p>

Li¹,

Yang²,

Qing³

et al. 2020

IJN

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Prosthesis-associated infections and aseptic loosening are major causes of implant failure. There is an urgent need to improve the antibacterial ability and osseointegration of orthopedic implants. Zinc oxide nanoparticles (ZnO-NPs) are a common type of zinccontaining metal oxide nanoparticles that have been widely studied in many fields, such as food packaging, pollution treatment, and biomedicine. The ZnO-NPs have low toxicity and good biological functions, as well as antibacterial, anticancer, and osteogenic capabilities. Furthermore, ZnO-NPs can be easily obtained through various methods. Among them, green preparation methods can improve the bioactivity of ZnO-NPs and strengthen their potential application in the biological field. This review discusses the antibacterial abilities of ZnO-NPs, including mechanisms and influencing factors. The toxicity and shortcomings of anticancer applications are summarized. Furthermore, osteogenic mechanisms and synergy with other materials are introduced. Green preparation methods are also briefly reviewed.

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Synthesis and characterization of zinc oxide nanoparticles by using polyol chemistry for their antimicrobial and antibiofilm activity

Cited by 139 publications

References 58 publications

Eco-friendly approach to control dengue vector Aedes aegypti larvae with their enzyme modulation by Lumnitzera racemosa fabricated zinc oxide nanorods

Eco-friendly approach to control dengue vector Aedes aegypti larvae with their enzyme modulation by Lumnitzera racemosa fabricated zinc oxide nanorods

Promising Antibiofilm Agents: Recent Breakthrough against Biofilm Producing Methicillin-Resistant Staphylococcus aureus

<p>Enhancing ZnO-NP Antibacterial and Osteogenesis Properties in Orthopedic Applications: A Review</p>

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