Synthesis and characterization of stabilized oxygen-releasing CaO2 nanoparticles for bioremediation

Yeh, Chia-Shen; Wang, Reuben; Chang, Wen‐Yi; Shih, Yang-hsin

doi:10.1016/j.jenvman.2018.01.068

Cited by 36 publications

(7 citation statements)

References 30 publications

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“…The ones at 871 and 718 cm −1 corresponded to O─O stretching vibration of peroxide, and finally the peak at 556 cm −1 was assigned to O─Ca─O stretching vibration of CaO 2 . The emerged peaks were in accordance with previous pertinent works and substantiated that the synthesized product was CPO (Rastinfard, Nazarpak, & Moztarzadeh, ; Yeh, Wang, Chang, & hsin Shih, ).…”

Section: Resultssupporting

confidence: 89%

Fabrication of amine‐decorated nonspherical microparticles with calcium peroxide cargo for controlled release of oxygen

Khorshidi

Karkhaneh

Bonakdar

2019

J Biomedical Materials Res

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Oxygen is an important signaling molecule which affects many behaviors of bone progenitor cells. Oxygen releasing biomaterials depend on their material and design are able to provide and modulate the desired oxygen for cells. To date, many oxygen releasing vehicles have been developed by incorporating microsized calcium peroxide (CPO) into polymeric matrixes. However, an oxygen releasing system based on nano CPO is still lacking. Not only can nanosized CPO provide more controllable oxygen release, but also can be loaded in vehicles of different shapes and sizes. Current research was conducted to take the advantages of nanomaterials as oxygen releasing components. To this end, CPO nanoparticles were synthesized using a hydrolysisprecipitation procedure and then loaded into the poly (lactide-co-glycolide) (PLGA) matrix via an electrospray process. The surface of PLGA/CaO 2 particles was decorated with amine functionalities to render them more bioactive through a controlled aminolysis reaction. The studies on PLGA/CaO 2 microparticles revealed that biconcave disk-like morphology with a mean diameter of 5.3 μm was formed. The particles persistently provide oxygen content of 35-67.5 mmHg up to 14 days which lies within the acceptable range for bone tissue engineering applications. PLGA/CaO 2 microparticles induced 208 and 76% increase in number of viable mesenchymal cells on 6th and 14th days of cell seeding comparing PLGA counterparts. Furthermore, the expression of two bone biomarkers, that is, alkaline phosphatase and osteocalcin, at protein level as well as the extent of calcium deposition was increased in the presence of PLGA/CaO 2 microparticles compared to PLGA ones. K E Y W O R D Sbone tissue engineering, calcium peroxide, microparticle, oxygen

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Section: Resultssupporting

confidence: 89%

Fabrication of amine‐decorated nonspherical microparticles with calcium peroxide cargo for controlled release of oxygen

Khorshidi

Karkhaneh

Bonakdar

2019

J Biomedical Materials Res

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“…00-044-1481) are also found in the diffractogram. 37 Furthermore, the PCL reflections were identified in the XRD of the PCL-CPO-M and PCL-F-CPO-M, and the CPO-related peaks were also observed with adequate clarity and intensity ( Figure 3A-iii and iv). These peaks are consistent with those presented in the literature, which confirms that the CPO was successfully incorporated in our microparticles.…”

Section: Resultsmentioning

confidence: 95%

“…Peaks corresponding to the O-Ca-O bending vibration mode of CaO 2 and CO 3 2 of the calcite group could be observed in the wide range of 1600 to 1300 cm −1 , thus corroborating with the XRD results of the materials with CPO ( Figure 3A-ii, iii and iv). 37 The absorption band at 875 cm −1 is attributed to the oxygen (O-O) bridge of CPO. 39…”

Section: Resultsmentioning

confidence: 99%

<p>Electrospraying Oxygen-Generating Microparticles for Tissue Engineering Applications</p>

Morais¹,

Wang²,

Vieira³

et al. 2020

IJN

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Background: The facile preparation of oxygen-generating microparticles (M) consisting of Polycaprolactone (PCL), Pluronic F-127, and calcium peroxide (CPO) (PCL-F-CPO-M) fabricated through an electrospraying process is disclosed. The biological study confirmed the positive impact from the oxygen-generating microparticles on the cell growth with high viability. The presented technology could work as a prominent tool for various tissue engineering and biomedical applications. Methods: The oxygen-generated microparticles fabricated through electrospraying processes were thoroughly characterization through various methods such as X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR) analysis, and scanning electron microscopy (SEM)/SEM-Energy Dispersive Spectroscopy (EDS) analysis. Results: The analyses confirmed the presence of the various components and the porous structure of the microparticles. Spherical shape with spongy characteristic microparticles were obtained with negative charge surface (ζ =-16.9) and a size of 17.00 ± 0.34 μm. Furthermore, the biological study performed on rat chondrocytes demonstrated good cell viability and the positive impact of increasing the amount of CPO in the PCL-F-CPO-M. Conclusion: This technological platform could work as an important tool for tissue engineering due to the ability of the microparticles to release oxygen in a sustained manner for up to 7 days with high cell viability.

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“…The calcium peroxide particles used in the above studies were larger than nanoscale. Their reference in this section was nonetheless pertinent given that smaller particles (which have been previously fabricated [147]) may generate more oxygen per weight [148]. To the authors' knowledge, the application of such technology to generate oxygen in an encapsulation structure in vivo has not been reported.…”

Section: 21mentioning

confidence: 99%

Nanotechnology in cell replacement therapies for type 1 diabetes

Ernst

Bowers

Wang

et al. 2019

Advanced Drug Delivery Reviews

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Islet transplantation is a promising long-term, compliance-free, complication-preventing treatment for type 1 diabetes. However, islet transplantation is currently limited to a narrow set of patients due to the shortage of donor islets and side effects from immunosuppression. Encapsulating cells in an immunoisolating membrane can allow for their transplantation without the need for immunosuppression. Alternatively, "open" systems may improve islet health and function by allowing vascular ingrowth at clinically attractive sites. Many processes that enable graft success in both approaches occur at the nanoscale level-in this review we thus consider nanotechnology in cell replacement therapies for type 1 diabetes. A variety of biomaterial-based strategies at the nanometer range have emerged to promote immune-isolation or modulation, proangiogenic, or insulinotropic effects. Additionally, coating islets within nano-thin polymer films has burgeoned as an islet protection modality. Materials approaches that utilize nanoscale features manipulate biology at the molecular scale, offering unique solutions to the enduring challenges of islet transplantation.

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Synthesis and characterization of stabilized oxygen-releasing CaO2 nanoparticles for bioremediation

Cited by 36 publications

References 30 publications

Fabrication of amine‐decorated nonspherical microparticles with calcium peroxide cargo for controlled release of oxygen

Fabrication of amine‐decorated nonspherical microparticles with calcium peroxide cargo for controlled release of oxygen

<p>Electrospraying Oxygen-Generating Microparticles for Tissue Engineering Applications</p>

Nanotechnology in cell replacement therapies for type 1 diabetes

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