Fabrication of amine‐decorated nonspherical microparticles with calcium peroxide cargo for controlled release of oxygen

Khorshidi, Sajedeh; Karkhaneh, Akbar; Bonakdar, Shahin

doi:10.1002/jbm.a.36799

Cited by 50 publications

(34 citation statements)

References 39 publications

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“…The broad peak of PLGA in the 2θ = 10°–25° region was observed in all microspheres and indicates the amorphous structure of PLGA. The characteristic diffraction peaks of CaO 2 at 2θ = 29.8°, 36.2°, 48.0°, and 53.4° correspond to the (0 0 2), (1 1 0), (1 1 2), and (1 0 3) crystalline planes of CaO 2 (Khorshidi et al, ). The presence of these peaks in the composite microspheres, especially at the greater CaO 2 concentrations, delineates the presence of CaO 2 as intact structures within the polymeric microspheres.…”

Section: Resultsmentioning

confidence: 99%

“…Calcium peroxide (CaO 2 , CPO) is a solid inorganic peroxide that has widely been used in the development of oxygen‐generating biomaterials (Huang et al, ; Khorshidi, Karkhaneh, & Bonakdar, ; Oh, Ward, Atala, Yoo, & Harrison, ; Pedraza, Coronel, Fraker, Ricordi, & Stabler, ; Wang et al, ). Upon exposure to water, CaO 2 hydrolytically decomposes following the equation below:

{CaO}_{2} + 2 H_{2} normalO \to Ca {(OH)}_{2} + H_{2} O_{2}

2 H_{2} O_{2} \to 2 H_{2} normalO + O_{2}

…”

Section: Introductionmentioning

confidence: 99%

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Regenerative engineered vascularized bone mediated by calcium peroxide

Daneshmandi

Laurencin

2020

J Biomedical Materials Res

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One of the main challenges hindering the clinical translation of bone tissue engineering scaffolds is the lack of establishment of functional vasculature. Insufficient vascularization and poor oxygen supply limit cell survival within the constructs resulting in poor osseointegration with the host tissue and eventually leading to inadequate bone regeneration. Inspired by cues from developmental biology, we regenerative engineered a composite matrix by incorporating calcium peroxide (CaO2) into poly(lactide‐co‐glycolide) (PLGA) microsphere‐based matrices and sought to assess whether the delivery of the byproducts of CaO2 decomposition, namely O2, Ca2+, and H2O2 could enhance the regeneration of vascularized bone tissue. The composite microspheres were successfully fabricated via the oil‐in‐water emulsion method. The presence and encapsulation of CaO2 was confirmed using scanning electron microscopy, energy dispersive x‐ray spectroscopy, thermogravimetric analysis, and X‐ray powder diffraction. The microspheres were further heat sintered into three‐dimensional porous scaffolds and characterized for their degradation and release of byproducts. The in vitro cytocompatibility of the matrices and their ability to support osteogenic differentiation was confirmed using human adipose‐derived stem cells. Lastly, an in vivo study was performed in a mouse critical‐sized calvarial defect model to evaluate the capacity of these matrices in supporting vascularized bone regeneration. Results demonstrated that the presence of CaO2 increased cellularization and biological activity throughout the matrices. There was greater migration of host cells to the interior of the matrices and greater survival and persistence of donor cells after 8 weeks, which in synergy with the composite matrices led to enhanced vascularized bone regeneration.

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Section: Resultsmentioning

confidence: 99%

{CaO}_{2} + 2 H_{2} normalO \to Ca {(OH)}_{2} + H_{2} O_{2}

2 H_{2} O_{2} \to 2 H_{2} normalO + O_{2}

…”

Section: Introductionmentioning

confidence: 99%

Regenerative engineered vascularized bone mediated by calcium peroxide

Daneshmandi

Laurencin

2020

J Biomedical Materials Res

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“…The oxygen release profiles achieved in the current study suggest that the desired oxygen release profile can be achieved by changing various process parameters. Such tunable systems would be highly desirable as the demand for oxygen varies in different applications 34‐36 …”

Section: Resultsmentioning

confidence: 99%

Influence of process parameters on the characteristics of oxygen‐releasing poly (lactic acid) microparticles: A multioptimization strategy

Nejati

Karimi‐Soflou

Karkhaneh

2020

Polymers for Advanced Techs

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Oxygen‐generating biomaterials have led to promising results in biomedical applications. Yet, the characteristics of these biomaterials need to meet the requirements of a specific application in order to be successful. In this study, hydrogen peroxide (H2O2) was used as the oxygen‐generating substance, and poly (l‐lactic acid) (PLLA) microparticles loaded with polyvinylpyrrolidone/hydrogen peroxide (PVP/H2O2) mixture were prepared using water‐in‐oil‐in‐water double emulsion technique. The experiments were carried out based on full factorial design where the impacts of PLLA concentration, H2O2:PVP molar ratio, and H2O2:organic phase volume ratio on microparticles' properties, including size, encapsulation efficiency, loading content, and percentage of initial burst release were assessed. Individual and multioptimization of responses were performed on the experimental data gained in the current study to investigate the effect of process parameters on the responses and fit the suitable model corresponding to the main and interactive effects. Recording both the H2O2 and O2 release of microparticles revealed that these profiles are also influenced by process variables, PLLA concentration in particular. These results enable accurate selection of optimal process variables for the fabrication of oxygen‐releasing PLLA microparticles with desirable characteristics for a wide variety of applications.

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“…[246] In another study, Khorshidi et al fabricated CPO nanoparticles and incorporated them in PLGA microparticles to enhance control over oxygen releasing of this material. [247] Appropriate bioinks can promote cell tissue interaction and cellular activity. Another important aspect of bioinks is the biomimicry ability of bioink that has a vital role in cell attachment and activity.…”

Section: Cell Viability In Microfluidic Bioprintingmentioning

confidence: 99%

Extrusion and Microfluidic‐Based Bioprinting to Fabricate Biomimetic Tissues and Organs

Davoodi

Sarikhani

Montazerian

et al. 2020

Adv Materials Technologies

127

110

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Next generation engineered tissue constructs with complex and ordered architectures aim to better mimic the native tissue structures, largely due to advances in 3D bioprinting techniques. Extrusion bioprinting has drawn tremendous attention due to its widespread availability, cost‐effectiveness, simplicity, and its facile and rapid processing. However, poor printing resolution and low speed have limited its fidelity and clinical implementation. To circumvent the downsides associated with extrusion printing, microfluidic technologies are increasingly being implemented in 3D bioprinting for engineering living constructs. These technologies enable biofabrication of heterogeneous biomimetic structures made of different types of cells, biomaterials, and biomolecules. Microfluiding bioprinting technology enables highly controlled fabrication of 3D constructs in high resolutions and it has been shown to be useful for building tubular structures and vascularized constructs, which may promote the survival and integration of implanted engineered tissues. Although this field is currently in its early development and the number of bioprinted implants is limited, it is envisioned that it will have a major impact on the production of customized clinical‐grade tissue constructs. Further studies are, however, needed to fully demonstrate the effectiveness of the technology in the lab and its translation to the clinic.

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Fabrication of amine‐decorated nonspherical microparticles with calcium peroxide cargo for controlled release of oxygen

Cited by 50 publications

References 39 publications

Regenerative engineered vascularized bone mediated by calcium peroxide

Regenerative engineered vascularized bone mediated by calcium peroxide

Influence of process parameters on the characteristics of oxygen‐releasing poly (lactic acid) microparticles: A multioptimization strategy

Extrusion and Microfluidic‐Based Bioprinting to Fabricate Biomimetic Tissues and Organs

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