Synthesis and characterization of silica nanoparticles from rice ashes coated with chitosan/cancer cell membrane for hepatocellular cancer treatment

Espinoza, Maria Janina Carrera; Lin, Kuen‐Song; Kunene, Sikhumbuzo Charles; Lin, Yousheng; Lin, Yi-Ting

doi:10.1016/j.ijbiomac.2022.12.235

Cited by 20 publications

(14 citation statements)

References 72 publications

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“…The cellular uptake of PBS (control), MNP-F127-3, MNP-F127-3-DOX, and free DOX was observed using fluorescence microscopy, as previously reported [ 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 ]. Briefly, a piece of coverslip was placed into each well of 6-well plates, and HepG2 cancerous cells were seeded on top at a cell density of 5 × 10 3 cells/well.…”

Section: Methodsmentioning

confidence: 79%

“…The MNP-F127-2 and MNP-F127-3 were loaded with DOX following our previous study [ 50 ]. Briefly, 3 mg each of MNP-F127-2 and MNP-F127-3 was separately mixed with 1 mg of DOX and 1 mL of DI water for 48 h under constant shaking in the dark.…”

Section: Methodsmentioning

confidence: 99%

“…The cytotoxicity assay was performed using human liver carcinoma cell lines (HepG2), following our previous studies [ 49 , 50 ]. Briefly, 1 × 10 6 cells were seeded in 96-well plates (n = 3) and incubated for 24 h. DMEM was replaced with fresh medium containing increasing concentrations of PBS (control), MNP-F127-3, MNP-F127-3-DOX, and free DOX.…”

Section: Methodsmentioning

confidence: 99%

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Synthesis and Characterization of Supermagnetic Nanocomposites Coated with Pluronic F127 as a Contrast Agent for Biomedical Applications

et al. 2023

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Nanomedicine has garnered significant interest owing to advances in drug delivery, effectively demonstrated in the treatment of certain diseases. Here, smart supermagnetic nanocomposites based on iron oxide nanoparticles (MNPs) coated with Pluronic F127 (F127) were developed for the delivery of doxorubicin (DOX) to tumor tissues. The XRD patterns for all samples revealed peaks consistent with Fe3O4, as shown by their indices (220), (311), (400), (422), (511), and (440), demonstrating that the structure of Fe3O4 did not change after the coating process. After loading with DOX, the as-prepared smart nanocomposites demonstrated drug-loading efficiency and drug-loading capacity percentages of 45 ± 0.10 and 17 ± 0.58% for MNP-F127-2-DOX and 65 ± 0.12 and 13 ± 0.79% for MNP-F127-3-DOX, respectively. Moreover, a better DOX release rate was observed under acidic conditions, which may be credited to the pH sensitivity of the polymer. In vitro analysis demonstrated the survival rate of approximately 90% in HepG2 cells treated with PBS and MNP-F127-3 nanocomposites. Furthermore, after treatment with MNP-F127-3-DOX, the survival rate decreased, confirming cellular inhibition. Hence, the synthesized smart nanocomposites showed great promise for drug delivery in liver cancer treatment, overcoming the limitations of traditional therapies.

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Section: Methodsmentioning

confidence: 79%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Synthesis and Characterization of Supermagnetic Nanocomposites Coated with Pluronic F127 as a Contrast Agent for Biomedical Applications

et al. 2023

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“…Larger pore diameters and, thus, higher flow rates of pure water through the membrane were made possible by the bigger silica particles. By choosing suitable-sized silica particles, the pores’ size may be controlled . The amorphous silica gel, with an average particle size of 1 μm, is difficult to dissolve in alkaline solutions due to the presence of traces of alumina on its surface, and the smaller silica gel particles used as high-performance liquid chromatography adsorbents (average particle sizes of 5 and 10 μm) are costly .…”

Section: Resultsmentioning

confidence: 99%

“…By choosing suitable-sized silica particles, the pores' size may be controlled. 31 The amorphous silica gel, with an average particle size of 1 μm, is difficult to dissolve in alkaline solutions due to the presence of traces of alumina on its surface, and the smaller silica gel particles used as high-performance liquid chromatography adsorbents (average particle sizes of 5 and 10 μm) are costly. 32 While having a smaller specific adsorption area, the membrane made with silica particles in the range of 15−40 μm is much cheaper, and by stacking many CS membranes together, the adsorptive capacity may be enhanced.…”

Section: Effect Of Chitosan Membrane Morphology and Flow Rate On The ...mentioning

confidence: 99%

Comparative Study of the Extraction of Cu(II) and Fe(II) Ions Using Chitosan and Modified Chitosan/Polyvinylpyrrolidone Adsorptive Membranes: Adsorption, Kinetic, and Thermodynamic Study

Arora

Jangid

Srivastava

et al. 2023

ACS Appl. Polym. Mater.

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The current work examined chitosan's adsorption capabilities for removing Cu(II) and Fe(II) ions from the aqueous phase in a batch equilibrium system. The membranes were prepared using the leaching-out method. The effects of the adsorbent's initial pH, concentration, temperature, and dose on adsorption were examined. Adsorption tests were conducted at temperatures ranging from 15 to 45 °C and initial concentration ranges of 20−400 mg/L. The observations from the adsorption isotherms fitted the Langmuir and Freundlich model adequately. The nonlinear form of the pseudo-first-order model was followed by the kinetics of Cu(II) and Fe(II) on chitosan, and the model parameters were reliably obtained. The endothermic and spontaneous character of Cu(II) and Fe(II) adsorption on chitosan adsorbents was verified by the computed negative values of standard Gibbs free energy and positive enthalpy changes. Finally, chitosan (CS) showed to be an efficient adsorbent for the removal of Cu(II) and Fe(II) ions due to its high adsorption capacity for Cu(II), which was 182.15 mg/g for C1, 331.28 mg/g for C2, and 384.31 mg/g for C3, and Fe(II), which was 201.67 mg/g for C1, 352.53 mg/g for C2, and 315.8 mg/g for C3 (where C1 is the CS membrane, C2 is the CS/silica membrane, and C3 is the CS/polyvinylpyrrolidone membrane).

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Sustainable Sources of Raw Materials for Additive Manufacturing of Bone‐Substituting Biomaterials

Putra

Zhou

Zadpoor

2023

Adv Healthcare Materials

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The need for sustainable development has never been more urgent, as the world continues to struggle with environmental challenges, such as climate change, pollution, and dwindling natural resources. The use of renewable and recycled waste materials as a source of raw materials for biomaterials and tissue engineering is a promising avenue for sustainable development. Although tissue engineering has rapidly developed, the challenges associated with fulfilling the increasing demand for bone substitutes and implants remain unresolved, particularly as the global population ages. This review provides an overview of waste materials, such as eggshells, seashells, fish residues, and agricultural biomass, that can be transformed into biomaterials for bone tissue engineering. While the development of recycled metals is in its early stages, we highlight the use of probiotics and renewable polymers to improve the biofunctionalities of bone implants. Despite the advances of additive manufacturing (AM), studies on AM waste‐derived bone‐substitutes are limited. It is foreseeable that AM technologies can provide a more sustainable alternative to manufacturing biomaterials and implants. The preliminary results of eggshell and seashell‐derived calcium phosphate and rice husk ash‐derived silica will likely pave the way for more advanced applications of AM waste‐derived biomaterials for sustainably addressing several unmet clinical applications.This article is protected by copyright. All rights reserved

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Synthesis and characterization of silica nanoparticles from rice ashes coated with chitosan/cancer cell membrane for hepatocellular cancer treatment

Cited by 20 publications

References 72 publications

Synthesis and Characterization of Supermagnetic Nanocomposites Coated with Pluronic F127 as a Contrast Agent for Biomedical Applications

Synthesis and Characterization of Supermagnetic Nanocomposites Coated with Pluronic F127 as a Contrast Agent for Biomedical Applications

Comparative Study of the Extraction of Cu(II) and Fe(II) Ions Using Chitosan and Modified Chitosan/Polyvinylpyrrolidone Adsorptive Membranes: Adsorption, Kinetic, and Thermodynamic Study

Sustainable Sources of Raw Materials for Additive Manufacturing of Bone‐Substituting Biomaterials

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