Synthesis and characterization of polyethyl cyanoacrylate nanoparticles loaded with capreomycin sulfate

Zhaparova, L.Zh.; Tazhbayev, Yerkeblan; Burkeev, M. Zh.; Kazhmuratova, A.T.; Zhumagalieva, T.S.; Ali, Syed Imran; Herk, Alex M. van

doi:10.1007/s11094-012-0724-1

Cited by 3 publications

(1 citation statement)

References 8 publications

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“…Number-average molecular weights of the PECA obtained from the polymerizations in the presence of IB are relatively low, varying between 3,500 and 4,600 g/mol with low polydispersity (around 1.05). These values are on the order of magnitude reported for the polymerization of ethyl cyanoacrylate by anionic polymerization in aqueous dispersions stabilized with surfactants [21][22][23]. The low molecular weights obtained in these polymerizations are due to a high termination rate of growing chains as a consequence of the large availability of H + when the reaction is carried out at low pH.…”

Section: Molecular Weightmentioning

confidence: 70%

Ibuprofen Release from Poly(ethyl cyanoacrylate) Nanoparticles Prepared by Semicontinuous Heterophase Polymerization

Balleño

Mendizabal-Ruiz

Saade³

et al. 2018

International Journal of Polymer Science

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Ibuprofen-loaded poly(ethyl cyanoacrylate) nanoparticles were prepared by semicontinuous heterophase polymerization of ethyl cyanoacrylate in the presence of ibuprofen; different surfactant concentration, pH, and temperature were used. Particle size was measured by quasi-light scattering and transmission electron microscopy, while the amount of drug released was determined by UV spectroscopy. Nanoparticles with diameters between 10 and 58 nm, loaded with ibuprofen, were obtained. The smallest particles and the higher drug loading were obtained at the highest pH tested. The analysis of the release data showed that the drug release profiles correspond to the Weibull model. Moreover, it was found that most of the ibuprofen is released within the first 80-120 min; initially the release rate is slow, but then it increases to finally decrease. This behavior contrasts with the reported burst of drug concentration in the plasma after oral administration of IB.

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Section: Molecular Weightmentioning

confidence: 70%

Ibuprofen Release from Poly(ethyl cyanoacrylate) Nanoparticles Prepared by Semicontinuous Heterophase Polymerization

Balleño

Mendizabal-Ruiz

Saade³

et al. 2018

International Journal of Polymer Science

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Nanoweapons Against Tuberculosis

Jampílek

Kráľová

2020

Nanoformulations in Human Health

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Nanoencapsulation of Antitumor and Antituberculosis Drug Preparations with Biocompatible Polymers

Burkeev

Kreuter

Herk

et al. 2014

J. Res. Updates Polym. Sci.

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Controlled release of drugs at the locus of the targeted disease is one of the most challenging research areas in the pharmaceutical field. Nowadays novel drug delivery systems on the basis of polymers are attracting great attention since they can improve therapeutic efficiency of potent drug preparations decreasing the risk of side effects. By developing colloidal drug delivery systems such as liposomes/vesicles and polymeric nanoparticles and nanocapsules the pharmacokinetics of the drug can be changed and thus the therapeutic efficiency of the drug can be increased. Nanoparticles with their special characteristics such as small particle size, large surface area and high capacity of carrying biologically active substances offer a number of advantages compared to other colloidal drug delivery systems [1,2].Controlled drug release systems are constructed on the basis of natural and biocompatible synthetic polymers. Among the most promising biocompatible polymers human serum albumin (HSA), polyalkyl cyanoacrylates (PACA) and poly-D,L-lactic acid (PLA) are of great importance. Nanoparticles on their basis have been proven to be efficient in treatment of serious and long-termed diseases such as tumors, tuberculosis and bacterial infections . Therefore this article is aimed to give a brief review on the research works devoted to the synthesis and investigation of polymeric nanoparticles and nanocapsules based on PACA, HSA and PLA for the past three decades.

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Synthesis and characterization of polyethyl cyanoacrylate nanoparticles loaded with capreomycin sulfate

Cited by 3 publications

References 8 publications

Ibuprofen Release from Poly(ethyl cyanoacrylate) Nanoparticles Prepared by Semicontinuous Heterophase Polymerization

Ibuprofen Release from Poly(ethyl cyanoacrylate) Nanoparticles Prepared by Semicontinuous Heterophase Polymerization

Nanoweapons Against Tuberculosis

Nanoencapsulation of Antitumor and Antituberculosis Drug Preparations with Biocompatible Polymers

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