Nanoweapons Against Tuberculosis

Jampílek, Josef; Kráľová, Katarína

doi:10.1007/978-3-030-41858-8_21

Cited by 4 publications

(2 citation statements)

References 202 publications

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“…Extremely popular are various nanoemulsions of lipidoid formations or colloidal nanodispersions of nanocrystals, i.e., nanoliposomes, solid lipid nanoparticles (NPs), and various other nanovesicles, dendrimers, polymer systems, tubules and quantum dots (QDs) are used as drug carriers [8][9][10][11][12][13][14][15][16][17][18]. Currently, nanoforms made from non-toxic biodegradable materials are preferred; however, in the case of nanoformulations for cancer therapy or diagnosis, inorganic carriers such as NPs of metals, metal oxides, metalloids and carbon are also used, which often potentiate the effect of the API itself [19][20][21][22][23][24][25][26][27][28][29][30]. It is important to mention that drugs in the nanoform acquire unique physicochemical properties and in particular their bioavailability after oral administration is modified, thanks to improved permeability through membranes [6,[31][32][33][34][35][36][37][38][39][40].…”

Section: Introductionmentioning

confidence: 99%

Advances in Drug Delivery Nanosystems Using Graphene-Based Materials and Carbon Nanotubes

Jampílek

Kráľová

2021

Materials

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Carbon is one of the most abundant elements on Earth. In addition to the well-known crystallographic modifications such as graphite and diamond, other allotropic carbon modifications such as graphene-based nanomaterials and carbon nanotubes have recently come to the fore. These carbon nanomaterials can be designed to help deliver or target drugs more efficiently and to innovate therapeutic approaches, especially for cancer treatment, but also for the development of new diagnostic agents for malignancies and are expected to help combine molecular imaging for diagnosis with therapies. This paper summarizes the latest designed drug delivery nanosystems based on graphene, graphene quantum dots, graphene oxide, reduced graphene oxide and carbon nanotubes, mainly for anticancer therapy.

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Section: Introductionmentioning

confidence: 99%

Advances in Drug Delivery Nanosystems Using Graphene-Based Materials and Carbon Nanotubes

Jampílek

Kráľová

2021

Materials

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“…An increase of the efficacy of individual agents can be ensured by fixed-dose drug combinations or antimicrobially active matrices. In addition, many formulations also protect drugs from degradation [15][16][17][18][19].This contribution deals with the biological activity of various types of nanoparticles/nanomaterials against bacteria and mycobacteria species.…”

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confidence: 99%

Impact of Nanoparticles on Bacteria and Mycobacteria

Jampílek¹,

Pisárčik²

2021

Proceedings of the 6th World Congress on Recent Advances in Nanotechnology

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Bacterial infections represent an increasing worldwide threat. The number of untreatable diseases decreased after the 1950s due to the introduction of antimicrobial agents. However, since the 1980s, morbidity has risen again, and mortality due to respiratory infections, AIDS, COVID-19 and tuberculosis now represents about 85% of world mortality from infections. The increase in the number of new infections is caused by general immunosuppression (primarily by tumour treatment, administration of immunosuppressive agents, wide-spectrum antibiotics and corticoids), a significant increase in the number of diabetic, HIV or SARS-CoV-2 positive patients and development of resistance to commonly used drugs. The resistance of common pathogens to first-line drugs increased by up to 100% during the last decade. Moreover, the resistance of some strains to second-or third-line drugs can be found. Development of cross-resistant or multidrugresistant strains is also a great problem [1][2][3][4].Selection of resistant microorganisms is especially caused by irrational and unavailing application of antimicrobial agents in human, veterinary medicine and in agriculture. Among the most frequent resistant bacterial strains there are methicillin-resistant Staphylococcus aureus, vancomycin-resistant S. aureus, vancomycin-resistant enterococci, penicillinand macrolides-resistant Streptococcus pneumoniae, cotrimoxazol-resistant Escherichia coli, the 3rd generation of cephalosporin-resistant E. coli and Klebsiella pneumoniae and carbapenem-resistant E. coli, K. pneumoniae and Pseudomonas aeruginosa [3]. In addition, tuberculosis (TB) caused by Mycobacterium tuberculosis remains one of the world's deadliest communicable diseases. Multidrug-, extensively drug-and totally drug-resistant TB strains are a serious worldwide problem [5].Thus, it can be stated that significant resistance to antimicrobials can be found at both Gram-positive and Gramnegative bacteria that cause serious infections. Bacterial resistance may complicate the treatment of infections regardless of how mild these infections were at the early stage. The consequence can be a prolonged disorder, treatment failure and patient's death [6][7][8][9].It is increasingly complicated to design new classes of antimicrobial compounds suitable for following rational development, therefore R&D of new antimicrobials imply risks, and thus many pharmaceutical originator companies have continued in development of me-too drugs but which does not solve the basic problem of resistance. Thus increasing bacterial resistance refers to the urgency to design new effective antibacterial drugs [10].Application of nanotechnology represents an excellent alternative for improvement of existing antimicrobial drugs. Nanomaterials are an alternative approach to treating and mitigating infections caused by resistant bacteria. Microbial cells are unlikely to develop resistance to nanomaterials, because, in contrast to conventional antibiotics, they exert toxicity through various mechanisms [11][12][13][14]. Usin...

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Impact of Nanoparticles on Protozoa

Plachá¹,

Jampílek²

2021

Nanotechnology in Medicine

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Nanoweapons Against Tuberculosis

Cited by 4 publications

References 202 publications

Advances in Drug Delivery Nanosystems Using Graphene-Based Materials and Carbon Nanotubes

Advances in Drug Delivery Nanosystems Using Graphene-Based Materials and Carbon Nanotubes

Impact of Nanoparticles on Bacteria and Mycobacteria

Impact of Nanoparticles on Protozoa

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