Advances in Drug Delivery Nanosystems Using Graphene-Based Materials and Carbon Nanotubes

Jampílek, Josef; Kráľová, Katarína

doi:10.3390/ma14051059

Cited by 92 publications

(46 citation statements)

References 273 publications

(295 reference statements)

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“…The use of drug delivery systems improves the efficacy of many existing drugs and allows the introduction of new therapies. GNRs are an excellent candidate for drug delivery systems [ 69 ] and genes delivery [ 36 ].…”

Section: Gnrs In Biomedicinementioning

confidence: 99%

Graphene Nanoribbons: Prospects of Application in Biomedicine and Toxicity

et al. 2021

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Graphene nanoribbons are a type of graphene characterized by remarkable electrical and mechanical properties. This review considers the prospects for the application of graphene ribbons in biomedicine, taking into account safety aspects. According to the analysis of the recent studies, the topical areas of using graphene nanoribbons include mechanical, chemical, photo- and acoustic sensors, devices for the direct sequencing of biological macromolecules, including DNA, gene and drug delivery vehicles, and tissue engineering. There is evidence of good biocompatibility of graphene nanoribbons with human cell lines, but a number of researchers have revealed toxic effects, including cytotoxicity and genotoxicity. Moreover, the damaging effects of nanoribbons are often higher than those of chemical analogs, for instance, graphene oxide nanoplates. The possible mechanism of toxicity is the ability of graphene nanoribbons to damage the cell membrane mechanically, stimulate reactive oxidative stress (ROS) production, autophagy, and inhibition of proliferation, as well as apoptosis induction, DNA fragmentation, and the formation of chromosomal aberrations. At the same time, the biodegradability of graphene nanoribbons under the environmental factors has been proven. In general, this review allows us to conclude that graphene nanoribbons, as components of high-precision nanodevices and therapeutic agents, have significant potential for biomedical applications; however, additional studies of their safety are needed. Particular emphasis should be placed on the lack of information about the effect of graphene nanoribbons on the organism as a whole obtained from in vivo experiments, as well as about their ecological toxicity, accumulation, migration, and destruction within ecosystems.

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Section: Gnrs In Biomedicinementioning

confidence: 99%

Graphene Nanoribbons: Prospects of Application in Biomedicine and Toxicity

et al. 2021

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“…Apart from being an anticancer agent, the graphene is also has photodynamic action (Yang et al, 2019). Graphene is generally used as a nanocarrier for drug delivery, especially anticancer drug delivery (Jampilek and Kralova, 2021). The graphene nanocomposites have better drug loading and protective action, targeted delivery, are suitable for theranostic role, and have effective photodynamic action.…”

Section: Theranostics Perspective Of Natural Anticancer Compoundsmentioning

confidence: 99%

Advanced Computational Methodologies Used in the Discovery of New Natural Anticancer Compounds

et al. 2021

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Natural chemical compounds have been widely investigated for their programmed necrosis causing characteristics. One of the conventional methods for screening such compounds is the use of concentrated plant extracts without isolation of active moieties for understanding pharmacological activity. For the last two decades, modern medicine has relied mainly on the isolation and purification of one or two complicated active and isomeric compounds. The idea of multi-target drugs has advanced rapidly and impressively from an innovative model when first proposed in the early 2000s to one of the popular trends for drug development in 2021. Alternatively, fragment-based drug discovery is also explored in identifying target-based drug discovery for potent natural anticancer agents which is based on well-defined fragments opposite to use of naturally occurring mixtures. This review summarizes the current key advancements in natural anticancer compounds; computer-assisted/fragment-based structural elucidation and a multi-target approach for the exploration of natural compounds.

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“…GOFs can range in size from molecular to semi-infinite 2-D structures; thus, their electronic structures vary from discrete molecular levels to being band-like due to an increase in dimensions [ 33 ]. Various articles have demonstrated potential application of the GFM including the limitations [ 34 , 35 ]. GO and rGO demonstrate variability in batch reproducibility in addition to varying quantity of oxide, hydroxide, and epoxide thereby limiting to control the chemo- and regioselectivity of functionalization reactions.…”

Section: Introductionmentioning

confidence: 99%

“…GOFs demonstrate high solubility in water, negative zeta potential, and relative ease of functionalization using carboxylate chemistry. Functionalized GOFs have demonstrated rapid blood pool clearance and renal excretion, hence can be considered as ideal candidate for theranostic drug development thus leading to its selection in the current study [ 35 ]. This study aimed to measure phagocytic cells’ activity against cancer cells, mediated by gold and graphene oxide flakes.…”

Section: Introductionmentioning

confidence: 99%

Gold Nanoparticles and Graphene Oxide Flakes Enhance Cancer Cells’ Phagocytosis through Granzyme-Perforin-Dependent Biomechanism

et al. 2021

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The study aimed to investigate the roles of gold nanoparticles (GNPs) and graphene oxide flakes (GOFs) as phagocytosis enhancers against cancer cells. The nanomaterials were characterized through SEM and UV-VIS absorptions. The GNPs and GOFs increased the macrophages’ phagocytosis ability in engulfing, thereby annihilating the cancer cells in both in vitro and in vivo conditions. The GNPs and GOFs augmented serine protease class apoptotic protein, granzyme, passing through the aquaporin class protein, perforin, with mediated delivery through the cell membrane site for the programmed, calibrated, and conditioned cancer cells killing. Additionally, protease inhibitor 3,4-dichloroisocoumarin (DCI) significantly reduced granzyme and perforin activities of macrophages. The results demonstrated that the GOFs and GNPs increased the activation of phagocytic cells as a promising strategy for controlling cancer cells by augmenting the cell mortality through the granzyme-perforin-dependent mechanism.

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Advances in Drug Delivery Nanosystems Using Graphene-Based Materials and Carbon Nanotubes

Cited by 92 publications

References 273 publications

Graphene Nanoribbons: Prospects of Application in Biomedicine and Toxicity

Graphene Nanoribbons: Prospects of Application in Biomedicine and Toxicity

Advanced Computational Methodologies Used in the Discovery of New Natural Anticancer Compounds

Gold Nanoparticles and Graphene Oxide Flakes Enhance Cancer Cells’ Phagocytosis through Granzyme-Perforin-Dependent Biomechanism

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