Ibuprofen Release from Poly(ethyl cyanoacrylate) Nanoparticles Prepared by Semicontinuous Heterophase Polymerization

Balleño, J. A.; Mendizabal-Ruiz, Adriana P.; Saade, H.; León-Gómez, Ramón Díaz de; Mendizábal, Eduardo; Ríos-Donato, Nely; López, Raúl G.

doi:10.1155/2018/4527203

Cited by 6 publications

(3 citation statements)

References 32 publications

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“…The Weibull equation can be applied to almost all types of dissolution curves. Here k w is the Weibull constant related to the inverse of the time required to release 63.2% of the drug, and n indicates the shape of the curve [ 35 , 36 ].

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Section: Resultsmentioning

confidence: 99%

Drug Delivery from Stimuli-Responsive Poly(N-isopropylacrylamide-co-N-isopropylmethacrylamide)/Chitosan Core/Shell Nanohydrogels

et al. 2022

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The synthesis of stimulus-responsive poly(N-isopropyl acrylamide-co-N-isopropyl methacrylamide)/chitosan core/shell nanohydrogels made by batch emulsion polymerization in the presence of chitosan (CS) micelles is reported. The ratio of monomers required to obtain copolymers with a volume phase transition temperature (TVPT) in the range of the temperatures observed in the human body in response to an infection (38 to 40 °C) was estimated with the Fox equation. The conversion was determined by gravimetry; mean particle size, size distribution, and thermal response were measured by quasi-elastic light scattering (QLS). The core/shell structure was confirmed by TEM, and FTIR showed the presence of N-isopropyl acrilamide (NIPA), N-isopropyl methacrylamide (NIPMA), and CS in the nanohydrogels. The nanohydrogels were loaded with the drug doxycycline hyclate, and their release kinetic profile was determined at pH 2.0 and 7.4 at their volume phase transition temperatures (TVPT). A higher amount of drug was released at acidic pH. Some mathematical models described in the literature were used to fit the experimental drug release data.

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Section: Resultsmentioning

confidence: 99%

Drug Delivery from Stimuli-Responsive Poly(N-isopropylacrylamide-co-N-isopropylmethacrylamide)/Chitosan Core/Shell Nanohydrogels

et al. 2022

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“…Each solution was transferred to a 10 mL volumetric flask and further diluted with deionized water. The maximum UV absorbance peak of the IBU was observed at 264 nm, [ 20 ] thus 264 nm was selected as the wavelength for this test. The concentrations of the solutions were plotted on the horizontal axis (X), while the corresponding absorbance values were plotted on the vertical axis (Y).…”

Section: Methodsmentioning

confidence: 99%

Sodium Alginate Hydrogel Carrier with Calcium Carbonate as Calcium Source for Ibuprofen Release

Lin,

Shi,

Meng

et al. 2023

Macro Chemistry & Physics

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Sodium alginate (SA) hydrogels crosslinked by calcium carbonate (CaCO3) and gluconolactone (GDL) were prepared, and were characterized by X‐ray diffraction (XRD) analysis and Fourier transform infrared (FTIR) spectrometer. The morphologies of the gel were observed with scanning electron microscopy (SEM). The SA hydrogels were used as carrier of the anti‐inflammatory drug IBU. The effects of GDL content, pH value and temperature on IBU release behavior were investigated and associated kinetic analysis was performed. The results showed that the cumulative release of IBU showed a trend of increasing and then decreasing with GDL content increased. The maximum cumulative release was observed when the molar ratio of Ca2+ in CaCO3 to GDL was 0.6. The release behavior of IBU was observed to have been influenced by pH levels, and it exhibited an optimal release trend at a pH value of 7.4. The impact of temperature on the release behavior of IBU was relatively insignificant compared to other factors. The Korsmeyer‐Peppas release kinetic model was well fitted, and suitable to explain the release behavior of IBU from the sodium alginate hydrogel.This article is protected by copyright. All rights reserved

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“…Compared to other drug delivery systems such as liposomes and polymeric nanoparticles, ZrO 2 nanostructures have been shown to have longer drug release profiles, which may be advantageous for certain applications. For example, a study found that NP micelle loaded with doxorubicin exhibited sustained release of the drug over a period of 48 h [172], while another study found that the release of the ibuprofen from polymeric nanoparticles occurs during the initial 80-120 min [173]. In other investigations, the loading and release efficiencies of a wide range of drugs such as ibuprofen, N-acetyl-l-cysteine, vancomycin, gentamicin, nitrofurantoin, and indomethacin characterized by a large range of polarity, molecular weight, and various functional groups were studied [25].…”

Section: Comparison Of the Drug Release Profiles Of Zro 2 Nanostructu...mentioning

confidence: 99%

Present and Future of ZrO2 Nanostructure as Reservoir for Drug Loading and Release

Radu

Drăgănescu

2023

Coatings

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Extensive research has been conducted on ZrO2 nanostructures due to their favorable biocompatibility, low toxicity, and promising prospects in various biomedical applications. They can be used as drug carriers, facilitating the administration of therapeutic substances into the body while enhancing their effectiveness and safety. This is achieved by regulating the timing, location, and rate at which drugs are released within the body. Several factors can influence the effectiveness of drug loading onto ZrO2 nanostructures, such as the physicochemical characteristics of the drugs, the surface properties of the ZrO2 nanostructures, and the specific methods used for drug loading. A wide range of drugs may be loaded onto ZrO2 nanostructures including anti-cancer drugs, antibiotics, anti-inflammatory drugs, antifungal drugs, anti-osteoporotic drugs, etc. The release kinetics of drugs can be influenced by different factors, such as the size and shape of ZrO2 nanostructures, the pH and temperature of the release medium, and the characteristics and molecular weight of the specific drug being released. While ZrO2 nanostructures have demonstrated significant potential as drug delivery systems, further research on these structures is essential to optimize drug loading and release strategies.

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Ibuprofen Release from Poly(ethyl cyanoacrylate) Nanoparticles Prepared by Semicontinuous Heterophase Polymerization

Cited by 6 publications

References 32 publications

Drug Delivery from Stimuli-Responsive Poly(N-isopropylacrylamide-co-N-isopropylmethacrylamide)/Chitosan Core/Shell Nanohydrogels

Drug Delivery from Stimuli-Responsive Poly(N-isopropylacrylamide-co-N-isopropylmethacrylamide)/Chitosan Core/Shell Nanohydrogels

Sodium Alginate Hydrogel Carrier with Calcium Carbonate as Calcium Source for Ibuprofen Release

Present and Future of ZrO2 Nanostructure as Reservoir for Drug Loading and Release

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