Synthesis and Characterization of Poly(DL-Lactic Acid) Nanoparticles Loaded with the Antituberculosis Drug Isoniazid

Burkeev, M. Zh.; Tazhbaev, E. M.; Zhaparova, L.Zh.; Zhappar, Nariman; Zhumagalieva, T.S.

doi:10.1007/s11094-016-1500-4

Cited by 4 publications

(4 citation statements)

References 5 publications

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“…The yield of PLA nanoparticles with isoniazid was 78.4 %. The system was found to be stable within the time which was confirmed by measurement of the surface charge of nanoparticles (-30-35 mV) [53].…”

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confidence: 66%

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Nanoparticles on the basis of polylactic acid and polylactic-co-glycolic acids loaded with drugs

Tazhbayev¹,

Burkeyev²,

Zhaparova³

et al. 2018

Bull. of the Kar. Univ. "Chem". Ser.

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Nanoparticles on the basis of polylactic acid and polylactic-co-glycolic acids loaded with drugs In this article a brief review on the research works devoted to the synthesis and investigation of polymeric nanoparticles and nanocapsules on the basis of polylactic acid and its copolymer with polyglycolic acid is given. Nanoparticles based on biocompatible and biodergadable polylactic acid and polylactic-co-glycolic acids gained special interest in pharmaceutical field as the carriers of different drug preparations. General methods of synthesizing nanosomal formulations of polylactic acid and polylactic-co-glycolic acids were described in this work. Among the perspective methods of obtaining the polymeric nanoparticles and nanocapsules of polylactides and its copolymer with glycolic acid loaded with drugs the nanoprecipitation and emulsion methods were found to be the most suitable for the systems used. Another method of synthesizing the nanosized systems of polylactic-co-glycolic acid is a double emulsion method which makes possible to obtain nanocapsules with optimal characteristics. The possibilities of immobilization of nanoparticulate systems based on these polymers with antitumor and antituberculosis drugs were considered. Some examples of polylactic acid and polylactic-co-glycolic acids' nanoparticles and nanocapsules loaded with drugs which have applications in medicine for the treatment of tumor and tuberculosis diseases were shown.

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confidence: 66%

“…M.Zh. Burkeev et al used the same method (nanoprecipitation) for the encapsulation of widely used antituberculosis drugs isoniasid and p-aminosalicylic acid (PASA) in PLA and PLGA nanoparticles [53]. Optimal conditions (solvent, the ratio polymer: drug, etc.)…”

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confidence: 99%

Nanoparticles on the basis of polylactic acid and polylactic-co-glycolic acids loaded with drugs

Tazhbayev¹,

Burkeyev²,

Zhaparova³

et al. 2018

Bull. of the Kar. Univ. "Chem". Ser.

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“…Burkeev et al [19] synthesized polylactide nanoparticles immobilized with isoniazid by the nanoprecipitation method. In this method, they used water as a non-solvent and acetone as a solvent and obtained NPs with a drug loading of 50 %.…”

Section: Resultsmentioning

confidence: 99%

Encapsulation of Isoniazid in Polylactide-Co-Glycolide Nanoparticles by Nanoprecipitation

Galiyeva¹,

Tazhbayev²,

Zhumagalieva³

et al. 2022

Bull. of the Kar. Univ. "Chem". Ser.

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The use of polymeric materials as drug carriers has several advantages, such as prolongation of drug action, reduction of drug side effects. In this study, we have considered the methods for the preparation of polylac-tide-co-glycolide (PLGA) polymeric nanoparticles with the anti-tuberculosis drug (ATD) isoniazid by nano-precipitation. Polymeric nanocarriers were obtained by varying individual parameters such as nature of sol-vent and non-solvent, drug/polymer ratio, and stabilizer concentration. It was determined that the average par-ticle size depends on the type of non-solvent. When alcohols were used, the average size increased in the se-quence: ethanol < isopropanol < isobutanol. The type of solvent is an important factor for the formation of nanoparticles and their final characteristics. With an increase in the drug/polymer ratio, the average size of nanoparticles also increased. The size of obtained nanoparticles varied from 93 to 869 nm. Thermogravi-metric and differential scanning calorimetry analyses were carried out to confirm the incorporation of the drug into the polymer matrix. In addition, polymer degradation and the degree of release of isoniazid from the polymeric matrix at different pH were studied. It has been shown that the nanoprecipitation method can be used not only for hydrophobic, but also for hydrophilic drugs.

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“…Carbohydrate-derived nanoparticles particularly, starch-based nanoparticles (SNCs) find enormous applications in the drug delivery research. The SNCs-based drug vehicles can be designed for the delivery of the covalently and/or physically attached drug molecules to the infected sites 15 – 19 . The urethane-functionalized starch in bulk and nano state acted as potential drug delivery devices in the field of sustained-release of drug molecules 20 – 23 .…”

Section: Introductionmentioning

confidence: 99%

Polyurethane-functionalized starch nanocrystals as anti-tuberculosis drug carrier

Desai

Mondal

Bera

2021

Sci Rep

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Studies related to loading ability and delivery of clinically used first-line anti-tuberculosis drugs (ATDs) such as isoniazid, rifampicin, pyrazinamide and streptomycin on the surface of starch-derived bulk and nanopolyurethanes (SBPUs and SNPUs) as drug delivery systems (DDS) have been focused to minimise or remove the drug-associated adverse effects. The efficiencies of nanopolyurethanes obtained from the differently substituted cyclic aliphatic and aromatic isocyanates have been studied for drug loading and release purposes. Different advanced instrumental techniques analysed the structural and morphological properties, thermal stability and crystallinity of the starch nanopolyurethans. Average particle sizes ranging from 27.35–42.38 nm to 126.89–218.60 nm for starch nanopolyurethans, SNPU3i and SNPU4i, respectively, were determined by high-resolution transmission electron microscopy. Similarly, the loading efficiency of ATDs to the surfaces of SNPUs and SBPUs was observed in the range of 60–97% while ATDs-loaded SNPUs showed a sustainable release profile for all ATDs except for streptomycin. However, most SBPUs provided burst-release for all the above-mentioned ATDs in pH-dependent studies. The anti-tuberculosis assay against the Mycobacterium tuberculosis H37Rv strain revealed that streptomycin-loaded SNPU4i and isoniazid-loaded SNPU7i are approximately 42 and 7 times more active than the native streptomycin and isoniazid, respectively.

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Synthesis and Characterization of Poly(DL-Lactic Acid) Nanoparticles Loaded with the Antituberculosis Drug Isoniazid

Cited by 4 publications

References 5 publications

Nanoparticles on the basis of polylactic acid and polylactic-co-glycolic acids loaded with drugs

Nanoparticles on the basis of polylactic acid and polylactic-co-glycolic acids loaded with drugs

Encapsulation of Isoniazid in Polylactide-Co-Glycolide Nanoparticles by Nanoprecipitation

Polyurethane-functionalized starch nanocrystals as anti-tuberculosis drug carrier

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