Synthesis and characterization of novel citric acid-based polyester elastomers

Djordjević, Ivan; Choudhury, Namita Roy; Dutta, Naba K.; Kumar, Saravana

doi:10.1016/j.polymer.2009.01.045

Cited by 120 publications

(100 citation statements)

References 32 publications

(67 reference statements)

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“…Fabrication of POC/bioglass films POC pre-polymer was synthesized by a polycondensation reaction reported elsewhere [21,22]. Briefly, equimolar amounts of CA and OD were weighed out and reacted in elevated temperature (140°C) for 1 h under nitrogen gas in order to produce POC pre-polymer.…”

Section: Synthesis Of Bioglassmentioning

confidence: 99%

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Fabrication and characterization of poly(octanediol citrate)/gallium-containing bioglass microcomposite scaffolds

et al. 2014

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Bone can be affected by osteosarcomae requiring surgical excision of the tumor as part of the treatment regime. Complete removal of cancerous cells is difficult and conventionally requires the removal of a margin of safety around the tumor to offer improved patient prognosis. This work considers a novel series of composite scaffolds based on poly(octanediol citrate) (POC) impregnated with galliumbased bioglass microparticles for possible incorporation into bone following tumor removal. The objective of this research was to fabricate and characterize these scaffolds and subsequently report on their mechanical and biological properties. The porous microcomposite scaffolds with various concentrations of bioglass (10, 20, 30 wt%) incorporated were fabricated using a salt leaching technique. The scaffolds exhibited compression modulus in the range of 0.3-7 MPa. The addition of bioglass increased the mechanical properties even though porosity increased. Furthermore, increasing the concentration of bioglass had a significant influence on glass transition temperature from 2.5°C for the pure polymer to around 25°C for 30 % bioglass-containing composite. The ion release study revealed that composites containing 10 % bioglass had the highest ion release ratio after 28 days of soaking in phosphate buffered saline. The interaction of bioglass phase with POC led to the formation of additional ionic crosslinks aside from covalent crosslinks which further resulted in increased stiffness and decreased weight loss. The osteoblast cells were well attached and growth on composites and collagen synthesis increased particularly with the 10 % bioglass concentration.

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Section: Synthesis Of Bioglassmentioning

confidence: 99%

“…In order to assess the fundamental properties of our POC-BG composite we have chosen the sample films (Fig. 6) over scaffolds, since the hydrophilic porous structure would contain significant amount of surface water trapped within the pores [21]. The swelling behavior of prepared films was investigated in water and PBS (Fig.…”

Section: Swelling Experimentsmentioning

confidence: 99%

Fabrication and characterization of poly(octanediol citrate)/gallium-containing bioglass microcomposite scaffolds

et al. 2014

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“…[13][14][15] To overcome these shortcomings, the development of novel biodegradable polyester elastomers, which are able to control their elastic properties and exibility to better match with the elastic nature, biocompatibility and degradation prole of so tissues, has increased considerably. 16,17 Several researchers have synthesized polyester elastomers based on polyols such as 1,8-octanediol, ethylene glycol, butylene glycol, castor oil or glycerol, and carboxylic acids such as citric acid, ricinoleic acid, and sebacic acid, [18][19][20][21][22][23][24][25] which nd application in so-tissue engineering as nerve-guidance, drug delivery, tissue adhesives and scaffolds to repair or replace body tissues. [1][2][3][4]19,26,27 Poly(glycerol sebacate) (PGS) represents the most studied member of the poly-polyol sebacate (PPS) family, all of which are attractive because they are inexpensive and endogenous monomers found in human metabolism.…”

Section: Introductionmentioning

confidence: 99%

Mechanical properties and degradation studies of poly(mannitol sebacate)/cellulose nanocrystals nanocomposites

et al. 2015

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A., 2008, 105, 2307). However, PPS generally display poor mechanical properties, in particular a low modulus, that limit the true potential of these materials in the biomedical field. Here, we introduce an approach to obtain nanocomposites based on poly(mannitol sebacate) (PMS) matrices reinforced with cellulose nanocrystals (CNCs) in order to improve the application range of these materials. Different strategies were used based on varying the feed ratios between mannitol : sebacic acid (1 : 1 and 1 : 2), crosslinking conditions and CNCs content, resulting in different degrees of crosslinking and, therefore, mechanical and degradation behavior. All of the developed nanocomposites displayed the expected mass loss during the degradation studies in simulated body fluid (SBF) similar to the neat matrix, however, doubling the sebacic acid feed ratio or extending the curing temperature and time, resulted in higher mechanical properties, structural integrity, and shape stability during a degradation time lessening mass loss rate. Changing mannitol : sebacic acid reaction ratios from 1 : 1 to 1 : 2 and for low crosslinking degree neat samples, the Young's modulus increases four-fold, while mass loss after 150 days of incubation is reduced by half. The Young's modulus range obtained with this process covers the range of human elastic soft tissues to tough tissues (0.7-200 MPa). IntroductionIn the past few years, there has been steady progress in the development of biodegradable polymers for application in the medical eld because these materials provide new opportunities to design less invasive and resorbable implants, tissue scaffolds, and medical devices that are able to avoid second revision surgeries, that limit the risk of infection and results in less trauma for the patient.5-8 Moreover, biodegradable polymeric systems which offer the possibility to tailor their mechanical properties from so to stiffer as well as the biodegradability ratio by varying the processing conditions also have additional advantages. Medical devices based on different classes of biodegradable polymers such as polyesters, polyanhydrides and polyurethanes have been widely investigated and some of them are commercially available as resorbable sutures, drug delivery systems, vascular gras, wafers and orthopaedic xation devices based, among others, on polylactic acid (PLA), polyglycolic acid (PGA), poly(lactic-co-glycolic acid) (PLGA), poly(3-caprolactone) (PCL), poly(p-dioxanone) (PDO), or poly(trimethylene carbonate) (PTMC).9,10 However, most of these polymeric systems have degradation rates that are not optimal for short-medium term applications. For example, it takes more than 24 months for poly(caprolactones) and poly(Llactic acid) to degrade in a biological environment, and from 2 to 24 months, depending on the ratio, for copolymers of polylactic acid (PLA) and polyglycolic acid (PGA). Also, the degradation rate for polyanhydrides is slow, around 12 months. 6,9,11 Moreover, these polymers have a lack of exibility and elasticity at bod...

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“…It is commonly used as a food additive; to make foods tart, to adjust the acidity, to generate carbon dioxide gas, and as an antioxidant to prevent the oils from becoming rancid [1][2][3][4][5][6]. CA is also used in industry such as plasticizers in plastics industry, detergents, metal cleaning, textile printing and dyeing, and photography [7][8][9][10][11][12]. CA crystallize into two different forms; the anhydrous CA is monoclinic with a space group of P2 1/a and the monohydrate CA is orthorhombic with a space group of P2 1 2 1 2 1 , and both the compounds have four molecules in the unit cell [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Investigation of Kinetic and Dosimetric Features of Citric Acid Using ESR Spectroscopy

Tuner

2012

Appl Magn Reson

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In the present work, dosimetric potential and temperature-dependent behaviors of the radicals produced upon c-irradiation of anhydrous and monohydrate citric acid were explored through a detail electron spin resonance (ESR) study. While unirradiated samples presented no ESR signal, irradiated samples were observed to exhibit an ESR spectrum consisting of many intense and weak resonance lines spread over a magnetic field range about 13 mT and centered at g = 2.0032. Although, the radicals produced upon c-irradiation have the same structures, the ESR spectra of both compounds of citric acid were observed to be different. An evaluation technique based on the variations of the characteristic resonance lines and the spectrum area was adopted to assign the radical species responsible for the observed experimental ESR spectrum and to determine their kinetic and dosimetric features.

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Synthesis and characterization of novel citric acid-based polyester elastomers

Cited by 120 publications

References 32 publications

Fabrication and characterization of poly(octanediol citrate)/gallium-containing bioglass microcomposite scaffolds

Fabrication and characterization of poly(octanediol citrate)/gallium-containing bioglass microcomposite scaffolds

Mechanical properties and degradation studies of poly(mannitol sebacate)/cellulose nanocrystals nanocomposites

Investigation of Kinetic and Dosimetric Features of Citric Acid Using ESR Spectroscopy

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