Synthesis and characterization of novel water soluble amphotericin B–arabinogalactan conjugates

Self-assembled amphotericin B-loaded polyglutamic acid nanoparticles: preparation, characterization and in vitro potential against Candida albicans

“…Investigators have employed different watersoluble polymers to develop encapsulated, conjugated AmBbased delivery systems, but have met with little success. [40][41][42][43][44][45][46][47][48] In some of the earlier efforts, polymers synergized the toxicity of AmB, 49 while in others the AmB was unable to retain the beneficial physicochemical properties associated with its liposomal form (AmB-L). 50 Although, AmB-cyclodextrin complexes showed improved water solubility, 49,51 they were found to be toxic to human red blood cells.…”

Streptomyces nodosusHost Strains Optimized for Polyene Glycosylation Engineering

“…Chemical modification studies have shown that this increases watersolubility and reduces toxicity. 11,12) Alteration of GT substrate specificity requires replacement of key amino acid residues or domain swapping. 13,14) The task is challenging and requires systems for testing large numbers of recombinant transferases for novel activities.…”

Polysaccharides from Larch Biomass

“…In medicine, an ophthalmic composition (eye drops/contact lens care solution) has been developed [26]. Membranotropicity caused by galactose fragments and realized through receptor mediated endocytosis makes AG a promising drug carrier to increase absorbability and selectivity of medical substances that are characterized by low bioavailability [27][28][29][30][31][32][33][34][35][36]. Applications of AG in photodynamic diagnostics, in oncological disease therapy and in gene therapy (targeted delivery of functional genes) are currently being explored [37][38][39].…”

“…It has been established that conjugates of AG and products of its modification increase the physiological effect of MS and decrease their toxicity [28,[46][47][48]; for instance, a conjugate of AG (9kDa) 9--Darabinofuranosyladenine-5'-monophosphate was 25-fold more active than the parent compound 9--D-arabinofuranosyladenine (araA) in decreasing the amount of hepatitis B virus, and the toxicity of the complex preparation is much lower than araA [28]. To increase reactivity of AG with MS, the synthesis of conjugates proceeds by bromination, phosphorylation, amination, formation of hydrazides or reaction with NaBH4 [27,33,34].…”