Synthesis and characterization of nitrile functionalized silver(I)-N-heterocyclic carbene complexes: DNA binding, cleavage studies, antibacterial properties and mosquitocidal activity against the dengue vector, Aedes albopictus

Asekunowo, Patrick O.; Haque, Rosenani A.; Razali, Mohd. R.; Avicor, Silas Wintuma; Wajidi, Mustafa Fadzil Farid

doi:10.1016/j.ejmech.2018.03.029

Cited by 42 publications

(16 citation statements)

References 51 publications

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“…3, It does not need to add auxiliary reagent (oxidant or reductant) or auxiliary means (light) . It is easier for metal complexes to hydrolyze and cleave plasmid DNA . The DNA cleavage activity of pBR322 DNA was studied by using agarose gel electrophoresis to observe the transformation of the circular supercoiled DNA (Form I) to nicked circular DNA (Form II) and linear DNA (Form III) .…”

Section: Resultsmentioning

confidence: 99%

Isomeric Effect on the anticancer Behavior of two Zinc (II) complexes based on 3,5‐bis(1‐imidazoly) pyridine: Experimental and Theoretical Approach

Zhu

Song

Liu³

et al. 2019

Applied Organom Chemis

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Two isomeric Zinc (II) complexes constructed by 3,5-bis(1-imidazoly) pyridine has been synthesized and characterized by single crystal X-ray diffraction, elemental analyses and infrared spectroscopy. The binding mode and ability of complex 1-2 with CT-DNA were studied by UV and fluorescence spectra. The intrinsic binding constant K b (K b1 = 2.305 × 10 4 M −1 , K b2 = 3.095 × 10 4 M −1 ) and the observed association constant K obs (K obs1 = 1.523*10 6 M −1 , K obs2 = 2.057*10 6 M −1 ) indicated that the insertion ability of complex 2 with CT-DNA is stronger than complex 1. Gel electrophoresis showed that complexes have a good ability to hydrolyze cleavage pBR322 plasmid DNA. The cytotoxicity and apoptosis studies showed that complexes exhibited excellent cytotoxic activity against HeLa cells, especially complex 2 had better growth inhibition than Cisplatin. Molecular docking study simulated the binding model of complexes with DNA (PDB:4av1), showing an imidazole plane of complex 2 can be inserted into a DNA base pair in relative parallel. Both complexes can be used as potential anticancer agents.

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Section: Resultsmentioning

confidence: 99%

Isomeric Effect on the anticancer Behavior of two Zinc (II) complexes based on 3,5‐bis(1‐imidazoly) pyridine: Experimental and Theoretical Approach

Zhu

Song

Liu³

et al. 2019

Applied Organom Chemis

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“…Mortality data for the dose-response effect was used to compute the median lethal concentration (LC 50 ) using Insecticide Resistance Monitoring Application-QCal (IRMA-QCal) (Lozano-Fuentes et al, 2012). LC 50 values with overlapping 95% confidence intervals (CIs) were considered not significantly different (Asekunowo et al, 2018). Finally, the number of trees infested by Anomis larvae before and after insecticide application on the field was computed using the tree infestation (%) formula above.…”

Section: Discussionmentioning

confidence: 99%

Outbreak and Insecticide Susceptibility of Pod Feeding-larvae on Cocoa in Ghana

Avicor¹,

Adu-Acheampong²,

Awudzi³

2021

JTAS

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Cocoa is an important foreign exchange earner and a major source of income for several households in Ghana. In 2018, a larval outbreak on cocoa pods was reported in Ghana. Although the origin is unknown, it was perceived to be a secondary pest outbreak. In this study, a survey was conducted in the outbreak areas to identify and determine the occurrence of the pest and its susceptibility to a commonly used insecticide. Field and laboratory studies were conducted to identify the pest, determine the level of infestation, insecticide susceptibility, and field management. The outbreak was mainly caused by larvae of Anomis leona (~96% infestation of cocoa trees in some communities) with extensive feeding damage (chewing channels/tunnels) on the pericarp of pods. Field populations of A. leona larvae from districts in the Central region subjected to bifenthrin were susceptible at the recommended field rate (0.0245%) for mirids after 48 h of exposure under laboratory conditions. The insecticide induced a median lethal concentration (LC50) of ≤0.0061% and ≤0.0018% on A. leona larvae from Jukwa and Twifo Praso in the Central region at 24 and 48 h of exposure, respectively. Field application of bifenthrin was able to suppress infestation. The findings show that Anomis larvae were responsible for the outbreak, inducing extensive damage on pods. Bifenthrin was toxic to the larvae and could be used to manage them on the field. The outbreak indicates the need to develop an integrated management and monitoring strategy for cocoa pests to minimize future outbreaks.

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“…As it was reported in the literatures [50][51][52], the DMSO did not exhibit any antimicrobial activity. The results are reported [27][28][29][30][31] in Table 1. Generally, all the Ag(I) complexes exhibited antibacterial activity against all bacterial strains except, the two compounds 3a and 3i were not active against Listeria monocytogenes.…”

Section: Biological Activitiesmentioning

confidence: 99%

“…The scavenging activity of the synthesized of the NHC precursors [27][28][29][30][31] is in The antioxidant activities for compounds 2a, 2d, 2g, 3g, and 3d are summarized in Figures 3 and 4. The results analysis indicated that the antiradical activity profiles obtained from the tested synthetic products 3g and 3d had improved and demonstrated antioxidant activity compared to the other products.…”

Section: Antioxidant Activitiesmentioning

confidence: 99%

“…Ag(I) complexes have been recently at the focal point with increased attention due to their usually strong antimicrobial and anticancer properties, and have more effective than other transition-metal complexes, and also, they have low toxicity for humans. Ag(I) complexes also promise to be agents capable of overcoming AMR and beating antibiotic resistant bacteria, fungi and parasites [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34]. Heterocyclic molecules are an important family of organic chemistry with a wide range of applications [35].…”

Section: Introductionmentioning

confidence: 99%

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Novel N-Heterocyclic Carbene Silver (I) Complexes: Synthesis, Structural Characterization, Antimicrobial, Antioxidant and Cytotoxicity Potential Studies

Slimani¹,

Dridi²,

Özdemır³

et al. 2022

Carbene

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Nowadays, N-heterocyclic carbene-based silver-complexes Ag(I) have been widely used as an organometallic drug candidate in medicinal and pharmaceutical chemistry researches due to their low toxicity. Due to the success of Ag(I) complexes in biological applications, interest in the synthesis and applications of such compounds is increasing rapidly. Therefore, in this study, a series of unsymmetrical N,N-disubstituted benzimidazolium salts were synthesized as N-heterocyclic carbene (NHC) (2a-2j). The interaction of these benzimidazolium salts having their two nitrogen atoms substituted by bulky groups with Ag2O in DMF has been carried out to afford Ag(I) complexes and characterized by 1H NMR, 13C NMR, FT-IR and elemental analyses. The antimicrobial activity of Ag(I) complexes was tested against some standard culture collections of Gram-negative, Gram-positive bacterial strains and Fungal strains, which are the most frequently isolated among the society and hospital-acquired infectious microorganisms as potential metallopharmaceutical agents. The Ag-NHC complexes showed effective antimicrobial activity against microorganisms with MIC values between 0.0024 and 1.25 mg/ml. Moreover, these Ag-NHC complexes exhibited significant antioxidant activities. In addition, of benzimidazoles salts 2,4 and Ag(I) complexes 3,5 were screened for their antitumor activity. The highest antitumor activity was observed for 3e and 3d Complexes.

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Synthesis and characterization of nitrile functionalized silver(I)-N-heterocyclic carbene complexes: DNA binding, cleavage studies, antibacterial properties and mosquitocidal activity against the dengue vector, Aedes albopictus

Cited by 42 publications

References 51 publications

Isomeric Effect on the anticancer Behavior of two Zinc (II) complexes based on 3,5‐bis(1‐imidazoly) pyridine: Experimental and Theoretical Approach

Isomeric Effect on the anticancer Behavior of two Zinc (II) complexes based on 3,5‐bis(1‐imidazoly) pyridine: Experimental and Theoretical Approach

Outbreak and Insecticide Susceptibility of Pod Feeding-larvae on Cocoa in Ghana

Novel N-Heterocyclic Carbene Silver (I) Complexes: Synthesis, Structural Characterization, Antimicrobial, Antioxidant and Cytotoxicity Potential Studies

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