Synthesis and Characterization of N,N’-(propane-1,2 diyldicarbamothioyl)dibenzamide

Kurt, Gülşah; Mercimek, Bedrettin

doi:10.3390/m578

Cited by 2 publications

(2 citation statements)

References 5 publications

(4 reference statements)

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“…Reaction of the in situ ‐prepared benzoyl isothiocyanate 5 (from benzoyl chloride and potassium isothiocyanate) with 1,2‐diaminopropane 23 in anhydrous acetone at reflux followed by acidification of the reaction product with 1 M HCl afforded the ethylene‐bis‐thiourea derivative 24 (Scheme ) .…”

Section: Synthetic Routes To Bis‐thioureasmentioning

confidence: 99%

Bis‐thiourea Derivatives and Their Utility in Synthesis of Mono‐heterocyclic, Bis‐heterocyclic, and Fused Heterocyclic Systems

Dawood

2019

Journal of Heterocyclic Chem

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Bis‐thiourea derivatives have distinguished synthetic potentialities. They are interesting substrates for construction of various classes of heterocycles, such as thiazoles, thiadiazoles, imidazoles, bis‐thiazoles, bis‐thiadiazoles, and fused heterocyclic systems. The current review is concerned on disclosing the synthetic and research applications of bis‐thioureas that were reported in the literature during the last decade.

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Section: Synthetic Routes To Bis‐thioureasmentioning

confidence: 99%

Bis‐thiourea Derivatives and Their Utility in Synthesis of Mono‐heterocyclic, Bis‐heterocyclic, and Fused Heterocyclic Systems

Dawood

2019

Journal of Heterocyclic Chem

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“…It is also known that various bis-acyl thiourea derivatives have been synthesized (31,32) to examine their bioactivity and that these compounds show antimicrobial (33) and antifungal (34,35), anticancer (36)(37)(38), antioxidant (39) as well as antidiabetic (40) and tissue-nonspecific alkaline phosphatase inhibitor properties (41). It has also been stated that some bis-acyl thiourea derivatives may be potential drug candidates for Alzheimer's disease by showing acetylcholinesterase enzyme inhibition activity (42).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Determination of Acid Dissociation Constants of Bis-Acyl Thiourea Derivatives

EFEOĞLU,

TİKEN,

SARI

et al. 2023

Journal of the Turkish Chemical Society Section A: Chemistry

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N,N'-((dodecane-1,12-diylbis(azanediyl))bis(carbonothioyl))bis(4-nitrobenzamide) 5 and N,N'-((dodecane-1,12-diylbis(azanediyl))bis(carbonothioyl))bis(3-nitrobenzamide) 6 as bis acyl thiourea derivatives were synthesized and their molecular structures were characterized using 1H NMR, 13C NMR, COSY, DEPT, HMQC, FT-IR, and HRMS techniques. The acid dissociation constants (pKa) of the bis-acyl thiourea derivatives 5, 6 were determined potentiometrically and spectrophotometrically. The pKa values of products 5, 6 were determined in 50% (v/v) dimethyl sulfoxide–water hydro-organic solvent in the presence of 0.1 molL1 ionic strength of NaCl and in the acidic medium at 25±0.1 °C, and two pKa values were calculated for each compound with the HYPERQUAD computer program using the data obtained from the potentiometric titrations performed. In addition, three pKa values for each compound were determined in the calculations using the HypSpec program from the data obtained from the spectrophotometric titrations performed under the conditions where the potentiometric titrations were performed. For compounds 5 and 6, spectrophotometrically, pKa1 was 3.56±0.08 and 3.87±0.01, respectively, pKa2 was 7.11±0.08 and 7.05±0.01, respectively, and pKa3 was 12.30±0.08 and 11.82±0.02, respectively. It can be said that pKa1, pKa2, and pKa3 values may belong to enol, enthiol, and NH, respectively. Moreover, for compounds 5 and 6, potentiometrically, pKa2 was 7.06±0.13 and 6.94±0.11, respectively, and pKa3 was 12.11±0.06 and 11.17±0.06, respectively, and it can be said that pKa2 and pKa3 values may belong to enthiol and NH, respectively. It is seen that the pKa values determined spectrophotometrically and potentiometrically are compatible with each other.

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Synthesis and Characterization of N,N’-(propane-1,2 diyldicarbamothioyl)dibenzamide

Abstract: n/

Cited by 2 publications

References 5 publications

Bis‐thiourea Derivatives and Their Utility in Synthesis of Mono‐heterocyclic, Bis‐heterocyclic, and Fused Heterocyclic Systems

Bis‐thiourea Derivatives and Their Utility in Synthesis of Mono‐heterocyclic, Bis‐heterocyclic, and Fused Heterocyclic Systems

Synthesis and Determination of Acid Dissociation Constants of Bis-Acyl Thiourea Derivatives

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