Synthesis and characterization of glycoconjugate tin(IV) complexes: In vitro DNA binding studies, cytotoxicity, and cell death

Tabassum, Sartaj; Khan, Rais Ahmad; Arjmand, Farukh; Sen, Subrata; Kayal, J. J.; Juvekar, Aarti; Zingde, Surekha M.

doi:10.1016/j.jorganchem.2011.01.012

Cited by 25 publications

(11 citation statements)

References 60 publications

(45 reference statements)

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“…The 119 Sn NMR chemical shift for similar type of tin(IV) chloride complexes reported in the wide range of -600 ± 50 ppm, showing a six coordinated octahedral environment around tin(IV) (Dubey et al, 2011b;Pettinari et al, 2006;Wrackmeyer, 1985). The tin(IV) complexes (1-4) exhibit a single sharp 119 Sn resonance in the range -629.8 to -625.3 ppm region supports a six coordinate octahedral geometry around tin atom (Chauhan and Arjmand, 2007;Tabassum et al, 2011).…”

Section: Nmr Spectroscopymentioning

confidence: 62%

Synthesis, spectroscopic characterization and computational studies of Schiff base complexes of tin(IV) chloride

Jaiswal

Kushwaha

Singh

et al. 2019

Main Group Metal Chemistry

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Reaction of anhydrous tin(IV) chloride with mono functional bidentate Schiff bases (sbnH), in 1:2 molar ratios, gives complexes of the type, [(sbn)2SnCl2] (1-4) (where, n=1-4; sb=2-(((4-chlorophenyl)imino)methyl)phenol, sb1H, I; 2-(((4-bromophenyl)imino)methyl) phenol, sb2H, II; 2-(((4-chlorophenyl)imino)methyl)-6-methoxyphenol, sb3H, III and 2-(((4-bromo phenyl)imino)methyl)-6-methoxyphenol, sb4H, IV. All the tin(IV) complexes (1-4) were colored solid and soluble in organic solvents. The synthesized complexes were characterized by elemental analysis (C, H, N and Sn), IR, UV-Vis, NMR (1H, 13C and 119Sn) spectroscopy and mass spectrometry. On the basis of spectroscopic studies, six coordination around tin atom has been proposed tentatively. The computational calculations using density functional theory (DFT) of ligands and complexes were also performed to obtained optimized molecular geometry, the highest occupied molecular orbital (HOMO), the lowest unoccupied molecular orbital (LUMO) and other parameter.

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Section: Nmr Spectroscopymentioning

confidence: 62%

Synthesis, spectroscopic characterization and computational studies of Schiff base complexes of tin(IV) chloride

Jaiswal

Kushwaha

Singh

et al. 2019

Main Group Metal Chemistry

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“…These phenomena indicated that the xanthones probably interact with ct DNA by intercalation mode, involving strong π-stacking interactions between xanthone rings of the compounds and DNA base pairs. 22) In order to study the binding ability of the compounds with DNA quantitatively, the binding constant K b was determined …”

Section: Resultsmentioning

confidence: 99%

Cytotoxic Activity and DNA-Binding Properties of Isoeuxanthone Derivatives

Wang

Yan

Gao

et al. 2014

CHEMICAL & PHARMACEUTICAL BULLETIN

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In this study, the interactions of different groups substituted isoeuxanthone derivatives with calf thymus DNA (ct DNA) were investigated by spectrophotometric methods and viscosity measurements. Results indicated that the xanthone derivatives could intercalate into the DNA base pairs by the plane of xanthone ring and the various substituents may influence the binding affinity with DNA according to the calculated quenching constant values. Furthermore, two tumor cell lines including the human cervical cancer cell line (HeLa) and human hepatocellular liver carcinoma cell line (HepG2) were used to evaluate the cytotoxic activities of xanthone derivatives by acid phosphatase assay. Analyses showed that the oxiranylmethoxy substituted xanthone exhibited more effective cytotoxic activity against the cancer cells than the other substituted xanthones. The effects on the inhibition of tumor cells in vitro agreed with the studies of DNA-binding.

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“…Ганцгорн, М.С. Алхусейн-Кулягинова «Механизмы цитотоксического действия оловоорганических соединений» полости человека (DWD) при значении IС 50 < 10 μΜ) [34].…”

Section: оловоорганические комплексы с N-донорными лигандамиunclassified

Mechanisms of the Cytotoxic Action of Organotin Compounds

et al. 2021

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This review analyzed the literature data on the in vitro preclinical study of the cytotoxic properties of organotin compounds, as well as the main mechanisms of their action. The latter consist in interacting with SH groups of proteins, initiating oxidative stress, binding to DNA, interacting with receptors, as well as activate apoptosis by increasing the expression of caspases, proapoptotic proteins, and decreasing antiapoptotic proteins. Organotin compounds, depending on the donor ligand, exhibit specifi c cytotoxicity towards certain tumor cell lines. The high cytotoxic potential indicates the possibility of further development in vivo and research of organotin compounds as candidates for the creation of drugs for anticancer and antimetastatic therapy.

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Synthesis and characterization of glycoconjugate tin(IV) complexes: In vitro DNA binding studies, cytotoxicity, and cell death

Cited by 25 publications

References 60 publications

Synthesis, spectroscopic characterization and computational studies of Schiff base complexes of tin(IV) chloride

Synthesis, spectroscopic characterization and computational studies of Schiff base complexes of tin(IV) chloride

Cytotoxic Activity and DNA-Binding Properties of Isoeuxanthone Derivatives

Mechanisms of the Cytotoxic Action of Organotin Compounds

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