Cytotoxic Activity and DNA-Binding Properties of Isoeuxanthone Derivatives

Wang, Hui Fang; Yan, Hong; Gao, Xianghua; Niu, Baolong; Guo, Ruijie; Wei, Liqiao; Xu, Bingshe

doi:10.1248/cpb.c13-00789

Cited by 4 publications

(4 citation statements)

References 28 publications

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“…Amongst these inhibitors are xanthones, which are plant-derived natural products with anti-tumor properties [76]. Semisynthetic and completely synthetic analogs of xanthones have also been studied as antitumor agents [77]. They have different levels of affinity and potency towards PKC isoforms.…”

Section: Uveal Melanomamentioning

confidence: 99%

Therapeutic targeting of oncogenic transcription factors by natural products in eye cancer

Zhang

Gallo

Tao

et al. 2018

Pharmacological Research

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Carcinogenesis has a multifactorial etiology, and the underlying molecular pathogenesis is still not entirely understood, especially for eye cancers. Primary malignant intraocular neoplasms are relatively rare, but delayed detection and inappropriate management contribute to poor outcomes. Conventional treatment, such as orbital exenteration, chemotherapy, or radiotherapy, alone results in high mortality for many of these malignancies. Recent sequential multimodal therapy with a combination of high-dose chemotherapy, followed by appropriate surgery, radiotherapy, and additional adjuvant chemotherapy has helped dramatically improve management. Transcription factors are proteins that regulate gene expression by modulating the synthesis of mRNA. Since transcription is a dominant control point in the production of many proteins, transcription factors represent key regulators for numerous cellular functions, including proliferation, differentiation, and apoptosis, making them compelling targets for drug development. Natural compounds have been studied for their potential to be potent yet safe chemotherapeutic drugs. Since the ancient times, plant-derived bioactive molecules have been used to treat dreadful diseases like cancer, and several refined pharmaceutics have been developed from these compounds. Understanding targeting mechanisms of oncogenic transcription factors by natural products can add to our oncologic management toolbox. This review summarizes the current findings of natural products in targeting specific oncogenic transcription factors in various types of eye cancer.

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Section: Uveal Melanomamentioning

confidence: 99%

Therapeutic targeting of oncogenic transcription factors by natural products in eye cancer

Zhang

Gallo

Tao

et al. 2018

Pharmacological Research

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“…Spectrophotometric titration as one of them correlates with the way in which these molecules interact with DNA, whereby the insertion of small molecules into adjacent base pairs provides a number of ways in which intercalation and groove binding play a key role. 2,3 This study was undertaken to explore the molecular mechanisms of interaction of xanthene derivatives with CT-DNA.…”

Section: Introductionmentioning

confidence: 99%

Procjena afiniteta vezanja DNA ksantenskih spojeva

Veljović,

Osmanović,

Salihović

et al. 2023

Kem. ind. (Online)

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Xanthene derivatives are an important class of heterocyclic compounds with a wide spectrum of pharmacological activities. In our previous investigations, we found the good antiproliferative activity of two xanthene derivatives, with minimal toxicity investigated by in vitro tests. In this study, we tested the interaction of compound 1 (powerful potent antiproliferative compound) with calf thymus DNA (CT-DNA) under physiological conditions by spectrophotometric titration. The probable prediction of binding and the type of interaction forces involved in the arrangement between xanthen derivatives and CT-DNA were explored also through molecular docking studies.<br /> The results indicated that compound 1 interacts with CT-DNA by grove binding. The binding constant was found to be 2.5 x 104 M-1 and indicates the non-covalent binding of compound 1 to CT-DNA. Docking study results proposed possible binding modes, with binding energies of -9.39 and -8.65 kcal/mol for compounds 1 and 2, respectively, which supported previously obtained in vitro results for antiproliferative activity.<br /> In addition to experimental investigation, density functional theory (DFT) calculation with B3LYP/6-31G*, B3LYP/6-31G**, and B3LYP/6-31+G* levels of theories was performed on compounds 1 and 2 to obtain optimized geometry, spectroscopic and electronic properties. <br /> These studies could help in understanding the mechanisms of toxicity, resistance, side effects of xanthene derivatives, and their binding action mechanism to DNA.

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“…This method needs to solve large-scale matrix equations, sometimes they are not properly solved. So we use the BP network to fuse the information of the pressure sensors, that not only overcomes above difficulties, but also improve the calculation accuracy and credibility [3,4].…”

Section: Introductionmentioning

confidence: 99%

The Temperature and Pressure Information Fusion Based on BP Network

Wang

Yang

et al. 2015

AMM

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The output of pressure sensor is affected by non-objection parameters in its application, its defect is the sensitivity to temperature. The method of the data fusion from the two sensors based on BP network can eliminate the side effect of temperatures and improve the accuracy and reliability for the pressure sensors. This method based on Levenberg-Marquardt algorithm of BP network has not only a simple network structure, but also a quick learning rate, showing a better prospect.

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Cytotoxic Activity and DNA-Binding Properties of Isoeuxanthone Derivatives

Cited by 4 publications

References 28 publications

Therapeutic targeting of oncogenic transcription factors by natural products in eye cancer

Therapeutic targeting of oncogenic transcription factors by natural products in eye cancer

Procjena afiniteta vezanja DNA ksantenskih spojeva

The Temperature and Pressure Information Fusion Based on BP Network

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