Synthesis and characterization of Gd3+- and Tb3+-doped iron oxide nanoparticles for possible endoradiotherapy and hyperthermia

Rękorajska, Aleksandra; Cichowicz, Grzegorz; Cyrański, Michał K.; Pękała, M.; Krysiński, Paweł

doi:10.1016/j.jmmm.2019.01.102

Cited by 15 publications

(16 citation statements)

References 38 publications

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“…Another report demonstrated that the particle size increases with increasing Gd ions doping to a certain level and then decreases due to disordering, as seen in Table 4. [94,160] A similar kind of behavior in particle size, has also been observed in Y 3+ doped manganese ferrite nanoparticle system, [160] Y x MnFe 2-x O 4 , (x = 0.0, 0.01, 0.02, 0.04, 0.08, 0.16) which maintains an identical AB 2 O 4 spinel structure like magnetite. From Table 4, doping strongly influences particle size.…”

Section: Impact Of Re Doping On Morphological Propertiessupporting

confidence: 64%

Rare‐Earth Doped Iron Oxide Nanostructures for Cancer Theranostics: Magnetic Hyperthermia and Magnetic Resonance Imaging

Laha

Thorat

Singh

et al. 2021

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He received his Ph.D. degree in materials sciences from the University of South Australia and his research primarily focuses on carbon capture using nanoporous materials. He has published 39 articles including review and research articles in high-quality materials science-based journals including Chemical Society Reviews and Advanced Materials. His contribution to the research has been acknowledged in the form of 1580 google scholar citations with an h-index of 18.

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Section: Impact Of Re Doping On Morphological Propertiessupporting

confidence: 64%

Rare‐Earth Doped Iron Oxide Nanostructures for Cancer Theranostics: Magnetic Hyperthermia and Magnetic Resonance Imaging

Laha

Thorat

Singh

et al. 2021

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“…Moreover, incorporation of the lanthanide dopants into the SPIONs puts together magnetic properties of the core with a novel tool in endoradiotherapy [ 27 ]. Thus, nonradioactive holmium are replaced with radioactive 166 Ho radionuclides emitting soft, β ( − ) radiation make possible its facile use towards cancer cells [ 28 , 29 ]. For that reason, several studies show successful labeling of the incorporation of radioactive lanthanides into the SPIONs [ 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

Hybrid System for Local Drug Delivery and Magnetic Hyperthermia Based on SPIONs Loaded with Doxorubicin and Epirubicin

et al. 2021

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Cancer is one of the most common causes of death worldwide, thus new solutions in anticancer therapies are highly sought after. In this work, superparamagnetic iron oxide nanoparticles (SPIONs) conjugated with anticancer drugs are synthesized and investigated as potential magnetic drug nanocarriers for local drug delivery and mild magnetic hyperthermia. We have obtained a hybrid system loaded with holmium and anticancer drugs and thoroughly studied it with respect to the size, morphology, surface modifications and magnetic properties, and interactions with the model of biological membranes, cytotoxicity. We present that nanoparticles having a round shape and size 15 nm are successfully stabilized to avoid their agglomeration and modified with doxorubicin or epirubicin within a controlled way. The number of drugs loaded into the SPIONs was confirmed with thermogravimetry. The hybrid based on SPIONs was investigated in touch with model biological membranes within the Langmuir-Blodgett technique, and results show that modified SPION interacts effectively with them. Results obtained with magnetic hyperthermia and biological studies confirm the promising properties of the hybrid towards future cancer cell treatment.

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“…SPIONs have been synthesized by several methods [9] such as solvothermal and co-precipitation synthesis, combustion, thermal decomposition of precursors, reverse micelles, and sol-gel methods, however, the most common is co-precipitation, offering simple and low-cost synthesis with control of particles size, crystallinity and magnetic properties [10], features necessary for use of SPIONs for magnetic hyperthermia, i.e., the therapeutic treatment of cancer by heat generated by SPIONs under the influence of alternating magnetic field [11,12]. Although doping of SPIONs with lanthanides like Gd 3+ or Ho 3+ , by substitution of Fe 3+ in Fe 3 O 4 core usually decreases magnetic properties, it can also broaden their applications in endoratiotherapy, when non-radioactive Ho cations are replaced with 166 Ho radionuclides emitting soft, β(-) radiation [13,14]. Such lanthanide-doped SPIONs are promising candidates for multimodal effect of targeted drug delivery, combined with 18.2 MΩ cm at 25 °C was obtained using the Milli-Q ultra-pure water filtering system from Merck (Warsaw, Poland).…”

Section: Introductionmentioning

confidence: 99%

Lanthanide-Doped SPIONs Bioconjugation with Trastuzumab for Potential Multimodal Anticancer Activity and Magnetic Hyperthermia

et al. 2020

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Iron oxide-based nanoparticles have been modified in their core with holmium(III) in an amount affecting only slightly their magnetic properties. Nanoparticles were conjugated covalently with biomolecule of trastuzumab (Herceptin®), the monoclonal antibody that recognizes cancer cells overexpressing HER2 receptors targeting such nanoparticles to the specified tumor tissues. Systematic studies of Ho3+-doped bioconjugates were carried out as a preliminary step for future replacement of ‘cold’ Ho with 166Ho radionuclide, emitting ‘soft’ beta(-) radiation for possible targeted radionuclide therapy. Physicochemical properties of the obtained bioconjugates were subsequently tested for use in magnetic hyperthermia, considered as an effective, low-invasiveness anticancer therapy. With such a system we expect to achieve both: active targeting and multimodal action by simultaneous internal and localized irradiation and magnetic hyperthermia of specific cancers.

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Synthesis and characterization of Gd3+- and Tb3+-doped iron oxide nanoparticles for possible endoradiotherapy and hyperthermia

Cited by 15 publications

References 38 publications

Rare‐Earth Doped Iron Oxide Nanostructures for Cancer Theranostics: Magnetic Hyperthermia and Magnetic Resonance Imaging

Rare‐Earth Doped Iron Oxide Nanostructures for Cancer Theranostics: Magnetic Hyperthermia and Magnetic Resonance Imaging

Hybrid System for Local Drug Delivery and Magnetic Hyperthermia Based on SPIONs Loaded with Doxorubicin and Epirubicin

Lanthanide-Doped SPIONs Bioconjugation with Trastuzumab for Potential Multimodal Anticancer Activity and Magnetic Hyperthermia

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