Hybrid System for Local Drug Delivery and Magnetic Hyperthermia Based on SPIONs Loaded with Doxorubicin and Epirubicin

Abstract

Cancer is one of the most common causes of death worldwide, thus new solutions in anticancer therapies are highly sought after. In this work, superparamagnetic iron oxide nanoparticles (SPIONs) conjugated with anticancer drugs are synthesized and investigated as potential magnetic drug nanocarriers for local drug delivery and mild magnetic hyperthermia. We have obtained a hybrid system loaded with holmium and anticancer drugs and thoroughly studied it with respect to the size, morphology, surface modifications and magnetic properties, and interactions with the model of biological membranes, cytotoxicity. We present that nanoparticles having a round shape and size 15 nm are successfully stabilized to avoid their agglomeration and modified with doxorubicin or epirubicin within a controlled way. The number of drugs loaded into the SPIONs was confirmed with thermogravimetry. The hybrid based on SPIONs was investigated in touch with model biological membranes within the Langmuir-Blodgett technique, and results show that modified SPION interacts effectively with them. Results obtained with magnetic hyperthermia and biological studies confirm the promising properties of the hybrid towards future cancer cell treatment.

Doxorubicin- and Trastuzumab-Modified Gold Nanoparticles as Potential Multimodal Agents for Targeted Therapy of HER2+ Cancers

“…By contrast, but in agreement with our results, it has been reported that chemotherapeutic agents (DOX or epirubicin) were more efficient than those synthesized with NPs [ 29 , 30 ]. Variations in the results may be due to different cancer cells used or some fluctuations in the DOX amount conjugated to AuNPs.…”

Facile Synthesis of Fe3O4@Au/PPy-DOX Nanoplatform with Enhanced Glutathione Depletion and Controllable Drug Delivery for Enhanced Cancer Therapeutic Efficacy

“…Fe 3 O 4 nanoparticles (NPs) are not only the preferred materials for magnetic targeting due to their high saturation magnetization [18][19][20][21][22][23], but also the focus of research on their chemical kinetic properties [24,25]. Fe 3 O 4 NPs have good internal stability and have been shown to be non-cytotoxic at neutral pH [26].…”

Synthesis and Characterization of Magnetic Drug Carriers Modified with Tb3+ Ions

“…In our previous works regarding magnetic NPs for magnetic hyperthermia, we found SAR values to be in a similar range (105–225 W/g) for lanthanide-doped IONPs [ 46 ]. Previously synthesized NPs doped with holmium were characterized by SAR values as high as 350 W/g for trastuzumab-modified SPIONs [ 47 ], 400 W/g for core–shell SPIONs trastuzumab bioconjugates [ 48 ], and 370 W/g for doxorubicin/epirubicin-modified SPION [ 49 ]. The SAR value itself (apart from a dependency on AMF frequency and field amplitude) is connected to the NPs’ size, shape, core modification, ligand attachment, and their amount.…”