Rare‐Earth Doped Iron Oxide Nanostructures for Cancer Theranostics: Magnetic Hyperthermia and Magnetic Resonance Imaging

Laha, Suvra S.; Thorat, Nanasaheb D.; Singh, Gurwinder; Sathish, Clastin I.; Yi, Jiabao; Dixit, Ambesh; Vinu, Ajayan

doi:10.1002/smll.202104855

Cited by 51 publications

(42 citation statements)

References 225 publications

(421 reference statements)

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“…Thus, the net magnetization of EuMZF is governed by the cation distribution of Fe 3+ , Mn 2+ and Zn 2+ ions in A and B sites. It was shown that rare-earth ions prefer to occupy the octahedral B sites due to their larger ionic radii [ 56 ]. As Eu 3+ ions enter the B sites, some Fe 3+ ions are replaced and forced to migrate to the A sites.…”

Section: Resultsmentioning

confidence: 99%

Effect of Europium Substitution on the Structural, Magnetic and Relaxivity Properties of Mn-Zn Ferrite Nanoparticles: A Dual-Mode MRI Contrast-Agent Candidate

et al. 2023

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Magnetic nanoparticles (MNPs) have been widely applied as magnetic resonance imaging (MRI) contrast agents. MNPs offer significant contrast improvements in MRI through their tunable relaxivities, but to apply them as clinical contrast agents effectively, they should exhibit a high saturation magnetization, good colloidal stability and sufficient biocompatibility. In this work, we present a detailed description of the synthesis and the characterizations of europium-substituted Mn–Zn ferrite (Mn0.6Zn0.4EuxFe2−xO4, x = 0.00, 0.02, 0.04, 0.06, 0.08, 0.10, and 0.15, herein named MZF for x = 0.00 and EuMZF for others). MNPs were synthesized by the coprecipitation method and subsequent hydrothermal treatment, coated with citric acid (CA) or pluronic F127 (PF-127) and finally characterized by X-Ray Diffraction (XRD), Inductively Coupled Plasma (ICP), Vibrating Sample Magnetometry (VSM), Fourier-Transform Infrared (FTIR), Dynamic Light Scattering (DLS) and MRI Relaxometry at 3T methods. The XRD studies revealed that all main diffraction peaks are matched with the spinel structure very well, so they are nearly single phase. Furthermore, XRD study showed that, although there are no significant changes in lattice constants, crystallite sizes are affected by europium substitution significantly. Room-temperature magnetometry showed that, in addition to coercivity, both saturation and remnant magnetizations decrease with increasing europium substitution and coating with pluronic F127. FTIR study confirmed the presence of citric acid and poloxamer (pluronic F127) coatings on the surface of the nanoparticles. Relaxometry measurements illustrated that, although the europium-free sample is an excellent negative contrast agent with a high r2 relaxivity, it does not show a positive contrast enhancement as the concentration of nanoparticles increases. By increasing the europium to x = 0.15, r1 relaxivity increased significantly. On the contrary, europium substitution decreased r2 relaxivity due to a reduction in saturation magnetization. The ratio of r2/r1 decreased from 152 for the europium-free sample to 11.2 for x = 0.15, which indicates that Mn0.6Zn0.4Eu0.15Fe1.85O4 is a suitable candidate for dual-mode MRI contrast agent potentially. The samples with citric acid coating had higher r1 and lower r2 relaxivities than those of pluronic F127-coated samples.

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Section: Resultsmentioning

confidence: 99%

Effect of Europium Substitution on the Structural, Magnetic and Relaxivity Properties of Mn-Zn Ferrite Nanoparticles: A Dual-Mode MRI Contrast-Agent Candidate

et al. 2023

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“…In the last decade, the nanomaterials have been hugely exploited for advanced biomedical applications [ 141 , 142 , 143 , 144 , 145 ]. As already stated, mostly nano-ferrites and metal oxide nanomaterials as well as graphene oxides and carbon nanotubes show intrinsic peroxidase-like activities [ 111 , 116 , 117 , 146 , 147 ].…”

Section: Nanomaterials Based Sensingmentioning

confidence: 99%

A Concise and Systematic Review on Non-Invasive Glucose Monitoring for Potential Diabetes Management

et al. 2022

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The current standard of diabetes management depends upon the invasive blood pricking techniques. In recent times, the availability of minimally invasive continuous glucose monitoring devices have made some improvements in the life of diabetic patients however it has its own limitations which include painful insertion, excessive cost, discomfort and an active risk due to the presence of a foreign body under the skin. Due to all these factors, the non-invasive glucose monitoring has remain a subject of research for the last two decades and multiple techniques of non-invasive glucose monitoring have been proposed. These proposed techniques have the potential to be evolved into a wearable device for non-invasive diabetes management. This paper reviews research advances and major challenges of such techniques or methods in recent years and broadly classifies them into four types based on their detection principles. These four methods are: optical spectroscopy, photoacoustic spectroscopy, electromagnetic sensing and nanomaterial based sensing. The paper primarily focuses on the evolution of non-invasive technology from bench-top equipment to smart wearable devices for personalized non-invasive continuous glucose monitoring in these four methods. With the rapid evolve of wearable technology, all these four methods of non-invasive blood glucose monitoring independently or in combination of two or more have the potential to become a reality in the near future for efficient, affordable, accurate and pain-free diabetes management.

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“…For that reason, RE doped nanoferrites are suitable for hyperthermia applications (Martinez-Boubeta et al, 2013). RE-doped Fe 3 O 4 shows higher magnetic-moments and a relatively larger diameter (S. S. Laha et al, 2022). Also, it shows stronger spin-orbit-coupling which is responsible for causing strain in Fe 3 O 4 lattice thereby, enhancing the anisotropy and magnetization.…”

Section: Iron-oxide Based Nanomaterials Used For Magnetic Hyperthermiamentioning

confidence: 99%

“…Various organic/inorganic polymers, biopolymers and surfactants, such as polyethylenegylcol (PEG), polyvinyl alcohol (PVA), dextran, chitosan, polyvinyl pyrrolidone (PVP), oleic acid and hyaluronic acid (HA), have been explored to carry out physical coating/functionalization (S. S. Laha et al, 2022). Various polymers used and the polymer type (end-grafted, surface adsorbed, phospholipids and di-block or co-polymers) are shown in Figure 11.…”

Section: Physical Modificationmentioning

confidence: 99%

Surface modified iron-oxide based engineered nanomaterials for hyperthermia therapy of cancer cells

Dhiman¹

2022

Preprint

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Magnetic hyperthermia is emerging as a promising alternative to the currently available cancer treatment modalities. Superparamagnetic iron-oxide nanoparticles (SPIONs) are extensively studied functional nanomaterials for biomedical applications, owing to their tunable physio-chemical properties and magnetic properties. Out of various ferrite classes, spinel and inverse-spinel ferrites are widely used but are affected by particle size distribution, particle shape, particle-particle interaction, geometry and crystallinity. Notably, their heating ability makes them suitable candidates for heat-mediated cancer cell ablation or hyperthermia therapy. Exposing SPIONs to an externally applied magnetic field of appropriate frequency and intensity cause them to release heat to ablate cancer cells. Majorly, three heating mechanisms are exhibited by magnetic nanomaterials: Nèel relaxation, Brownian relaxation and hysteresis losses. In SPIONs, Nèel and Brownian relaxations dominate whereas hysteric losses are negligible. These nanomaterials possess high magnetization values capable of generating heat to ablate cancer cells. Furthermore, surface functionalization of these materials imparts the ability to selectively target cancer cells and deliver cargo to the affected area sparing the normal body cells. The surface of nanoparticles can be functionalized with various physical, chemical and biological coatings. Moreover, hyperthermia can be applied in combination with other cancer treatment modalities in order to enhance the efficiency of treatment.

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Rare‐Earth Doped Iron Oxide Nanostructures for Cancer Theranostics: Magnetic Hyperthermia and Magnetic Resonance Imaging

Cited by 51 publications

References 225 publications

Effect of Europium Substitution on the Structural, Magnetic and Relaxivity Properties of Mn-Zn Ferrite Nanoparticles: A Dual-Mode MRI Contrast-Agent Candidate

Effect of Europium Substitution on the Structural, Magnetic and Relaxivity Properties of Mn-Zn Ferrite Nanoparticles: A Dual-Mode MRI Contrast-Agent Candidate

A Concise and Systematic Review on Non-Invasive Glucose Monitoring for Potential Diabetes Management

Surface modified iron-oxide based engineered nanomaterials for hyperthermia therapy of cancer cells

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