Synthesis and characterization of cross-linked zerumbone loaded zeolite Y-gelatin for oral controlled release

Salleh, Norashikin; Mahat, Mohd Muzamir; Yahaya, Saiful Zaimy; Ramli, Ratna Zuarni

doi:10.1063/5.0023157

“…The cross-linked sample was freed from oil through repeated washing with isopropyl alcohol, and this experiment is repeated for 5,10, and 15 v/v% of ZER concentrations. All samples were kept in a desiccator until further use [20].…”

Section: Methodsmentioning

confidence: 99%

Kinetic and Mechanism of Zerumbone Release from Cross-linked Gelatin-Zeolite Y Hybrid for Oral Anticancer Drug Delivery

Norashikin Salleh,

Mohd Muzamir Mahat,

Sabrina M. Yahaya

et al. 2024

ARMNE

0

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A hybrid of zeolite Y-gelatin film as an oral dosage form for the natural anticancer drug was achieved by homogenously incorporating the drug-loaded zeolite Y into the gelatin solution. Drug ability was analyzed using computational and experimental approaches, drug encapsulation efficiency via the BET method, and possible interactions by FTIR analyses. Zerumbone released was done in both pH 1.2 and pH 7.4 mimicking the human gastrointestinal tract conditions for 24 hrs and subjected to kinetics study via suitable mathematical models to determine what governs the drug release with the results indicating that a sustained delivery of once-daily oral dosage form could be achieved.

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“…The cross-linked sample was freed from oil through repeated washing with isopropyl alcohol, and this experiment is repeated for 5,10, and 15 v/v% of ZER concentrations. All samples were kept in a desiccator until further use [19].…”

Section: Methodsmentioning

confidence: 99%

Kinetic and Mechanism of Zerumbone Release from Cross-linked Gelatin-Zeolite Y Hybrid for Oral Anticancer Drug Delivery

Norashikin Salleh,

Mohd Muzamir Mahat,

Sabrina M. Yahaya

et al. 2024

ARFMTS

0

View full text Add to dashboard Cite

A hybrid of zeolite Y-gelatin film as an oral dosage form for the natural anticancer drug was achieved by homogenously incorporating the drug-loaded zeolite Y into the gelatin solution. Drug ability was analyzed using computational and experimental approaches, drug encapsulation efficiency via the BET method, and possible interactions by FTIR analyses. Zerumbone released was done in both pH 1.2 and pH 7.4 mimicking the human gastrointestinal tract conditions for 24 hrs and subjected to kinetics study via suitable mathematical models to determine what governs the drug release with the results indicating that a sustained delivery of once-daily oral dosage form could be achieved.

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“…The ability to release the compound over an extended period of time at a controlled rate is generally more effective and safer, since it overcomes the possible toxicity associated with the drastic accumulation of the drug in the body over a short period. The design and preparation of cross-linked zeolite Y/gelatine composite was developed using glutaraldehyde as cross-linking agent targeting to prolong the duration of zerumbone released for 24 h [ 141 ]. The solid state of zerumbone after loading remained crystalline, ensuring no form changes during storage.…”

Section: Formulation Strategies To Enhance the Solubility And Bioavai...mentioning

confidence: 99%

Healthy Zerumbone: From Natural Sources to Strategies to Improve Its Bioavailability and Oral Administration

Ibáñez

¹

,

Sánchez-Ballester

²

,

Blázquez

³

2022

Plants

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Zerumbone is a multifunctional compound with antimicrobial, antitumor, hyperalgesic, antioxidant and anti-inflammatory applications, and constitutes a point molecule for the future synthesis of derivatives with improved efficiency. This monocyclic sesquiterpenoid is found in high content in wild ginger (Zingiber zerumbet Smith), a perennial herb with economic importance as an ornamental as well as a medicinal plant. The presence of zerumbone is a distinctive feature that allows identification and differentiation from other species, not only in Zingiber, but also in Curcuma, Alpinia, Boesenbergia, Ethlingera and Ammomum spp., as well as related families (Costaceaee). To successfully use zerumbone in areas such as medicine, food and agriculture, further research on improving its low solubility and bioavailability, as well as its preservation, is a major current priority. In addition, despite its promising pharmacological activities, preclinical and clinical studies are required to demonstrate and evaluate the in vivo efficacy of zerumbone.

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Synthesis and characterization of cross-linked zerumbone loaded zeolite Y-gelatin for oral controlled release

Cited by 5 publications

References 25 publications

Kinetic and Mechanism of Zerumbone Release from Cross-linked Gelatin-Zeolite Y Hybrid for Oral Anticancer Drug Delivery

Kinetic and Mechanism of Zerumbone Release from Cross-linked Gelatin-Zeolite Y Hybrid for Oral Anticancer Drug Delivery

Kinetic and Mechanism of Zerumbone Release from Cross-linked Gelatin-Zeolite Y Hybrid for Oral Anticancer Drug Delivery

Healthy Zerumbone: From Natural Sources to Strategies to Improve Its Bioavailability and Oral Administration

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