Synthesis and characterization of biocompatible tigecycline imbibed electrospun poly ε-caprolactone urethane urea fibers

Sabitha, M.; Rajiv, Sheeja

doi:10.1039/c4ra08458f

Cited by 12 publications

(3 citation statements)

References 31 publications

(22 reference statements)

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“…Ampicillin and cefepime were loaded in polyacrylic acid and graphene-oxide crosslinked mesh, which exhibited no-inflammatory response at S. aureus infected superficial wound (Altinbasak et al, 2018). There are other wound healing mesh scaffolds (i.e., poly-3-caprolactone urethane, cellulose-PVA, and N-maleoyl chitosan) were explored to supply different kinds of antibiotics such as tigecycline, gentamicin sulfate, and tetracycline hydrochloride to eliminate pathogens from the wound bed (Sabitha & Rajiv, 2015). Vancomycin eluting poly[lactic-co-glycol acid] (PLGA) mesh showed prolonged 8 weeks antibiotic release after implantation at the brain tissue (Tseng et al, 2013).…”

Section: Release Active Mat or Meshmentioning

confidence: 99%

Advancements in release‐active antimicrobial biomaterials: A journey from release to relief

Bhattacharjee

Ghosh

Patra

et al. 2021

WIREs Nanomed Nanobiotechnol

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Section: Release Active Mat or Meshmentioning

confidence: 99%

Advancements in release‐active antimicrobial biomaterials: A journey from release to relief

Bhattacharjee

Ghosh

Patra

et al. 2021

WIREs Nanomed Nanobiotechnol

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“…Sabitha and Rajiv applied a different approach to include drugs into electrospun fibers by facilitating imbibition of tigecycline in PCL urethane urea microfibers. 121 This was performed by immersing the fibers in a tigecycline solution. The diameter of the fibers was 1.5-2 µm after drug imbibition has taken place.…”

Section: Controlled Drug Release With Electrospun Micro and Nanofibersmentioning

confidence: 99%

Fiber Based Approaches as Medicine Delivery Systems

Sharifi

Sooriyarachchi

Altural

et al. 2016

ACS Biomater. Sci. Eng.

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The goal of drug delivery is to ensure that therapeutic molecules reach the intended target organ or tissue, such that the effectiveness of the drug is maximized. The efficiency of a drug delivery system greatly depends on the choice of drug carrier. Recently, there has been growing interest in using micro-and nanofibers for this purpose. The reasons for this growing interest include these materials' high surface area to volume ratios, ease of fabrication, high mechanical properties, and desirable drug release profile. Here, we review developments in using these materials made by the most prevalent methods of fiber fabrication: electrospinning, microfluidics, wet spinning, rotary spinning, and self-assembly for drug delivery purposes. Additionally, we discuss the potential to use these fiber based systems in research and clinical applications.

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“…Aromatic diisocyanates prepared polyurethane of better mechanical properties; however, the aromatic diisocyanates degrade in vivo to carcinogenic aromatic diamines . Therefore, aliphatic diisocyanates are usually used in the synthesis of polyurethane scaffolds or polyurethane biomaterials . The hard segments of the polyurethane material synthesized from aliphatic diisocyanate (1,4‐diisocyanate butane and lysine methyl ester diisocyanate) had been modified similar to methylene diphenyl diisocyanate (MDI)‐based polyurethane by incorporating diurea diol chain extenders that were synthesized from amino acid derivatives (TyA and Tyr) with polyethylene glycol (the polyols) .…”

Section: Introductionmentioning

confidence: 99%

One‐pot synthesis of palm oil‐based polyester polyol for production of biodegradable and biocompatible polyurethane

Yeoh

Lee

Kang

et al. 2018

J of Applied Polymer Sci

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Palm oil-based polyester polyol was synthesized by reacting epoxidized palm olein with malonic acid under a convenient one-pot synthesis method. The optimum reaction time, temperature, and functionality molar ratio were determined. The optimal polyol consisted of hydroxyl and acid values of 98.19 and 1.44 mg KOH/g sample, 95% conversion of epoxides and M n of 5201 Da; and the chemical structure was elucidated by Fourier transform infrared , Carbon-13 nuclear magnetic resonance (NMR), and 1 H-NMR. The polyol was appeared as light-yellowish liquid with cloud and pour points of 12 and 10 C and reacted with isophorone diisocyanate to produce polyurethane with interconnected pores ranged 35-2165 μm, porosity ranged 89-90%, tensile strength ranged 59-78 kPa, and compression stress ranged 48-55 kPa. The polyurethanes showed 120-260% water-uptake and controlled mass loss (1.6-15.3%) after 28 days of enzymatic degradation. PU 1 demonstrated slight cytotoxicity with cell proliferation and adhesion observed after 24 h incubation, demonstrated its potential as biomaterial for biomedical applications.PU 1, PU 2, and PU 3 were synthesized by reacting polyester polyol with IPDI at isocyanate index of 1.0, 1.2, and 1.4, respectively. ARTICLEWILEYONLINELIBRARY.COM/APP

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Synthesis and characterization of biocompatible tigecycline imbibed electrospun poly ε-caprolactone urethane urea fibers

Abstract: Polyester urethane urea fibers were immersed in a broad spectrum glycylcycline antibiotic (tigecycline) and characterized for the treatment of infected wounds.

Cited by 12 publications

References 31 publications

Advancements in release‐active antimicrobial biomaterials: A journey from release to relief

Advancements in release‐active antimicrobial biomaterials: A journey from release to relief

Fiber Based Approaches as Medicine Delivery Systems

One‐pot synthesis of palm oil‐based polyester polyol for production of biodegradable and biocompatible polyurethane

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