Synthesis and characterization of bioactive binuclear transition metal complexes of Schiff base ligand derived from 4-amino-pyrimidine-2-one, diacetyl and glycine

Srivastava, Abhay Nanda; Singh, Netra Pal; Shriwastaw, Chandra Kiran

doi:10.2298/jsc130123148s

Cited by 19 publications

(7 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The magnetic moment values of the synthesized transition metal chelates are depicted in the electronic supplementary material, table S2. The square-pyramidal geometry for the oxovanadium complexes (1), ( 8) and (15) was verified by their experimental magnetic moments ranging from 1.70 to 1.76 Bohr's magneton (BM) signifying only one unpaired electron [49]. The chromium complexes (2), ( 9) and ( 16) displayed magnetic moment values ranging from 3.82 to 3.91, confirming their octahedral geometry and paramagnetic nature owing to the d-orbital containing three unpaired electrons.…”

Section: Magnetic Susceptibilitymentioning

confidence: 77%

Metal incorporated aminothiazole-derived compounds: synthesis, density function theory analysis,in vitroantibacterial and antioxidant evaluation

et al. 2021

View full text Add to dashboard Cite

The present study advocates the combined experimental and computational study of metal-based aminothiazole-derived Schiff base ligands. The structure and electronic properties of ligands have been experimentally studied by spectroscopic methods (UV-Vis, FT-IR, 1 H-NMR and 13 C-NMR), mass spectrometry, elemental analysis and theoretically by density function theory (DFT). Computational calculations employing the B3LYP/6-31 + G(d,p) functional of DFT were executed to explore the optimized geometrical structures of ligands along with geometric parameters, molecular electrostatic potential (MEP) surfaces and frontier molecular orbital (FMO) energies. Global reactivity parameters estimated from FMO energy gaps signified the bioactive nature of ligands. The synthesized ligands were used for chelation with 3 d -transition metals [VO(IV), Cr(III), Fe(II), Co(II), Ni(II), Cu(II) and Zn(II)] in 1 : 2 (metal : ligand) molar ratio. The spectral and magnetic results confirmed the formation of octahedral geometry around all the divalent and trivalent metal centres, whereas the tetravalent vanadyl centres were confirmed to have square-pyramidal geometry. All the as-synthesized compounds were investigated for in vitro antibacterial potential against two Gram-negative ( Salmonella typhimurium and Escherichia coli ) and two Gram-positive ( Bacillus subtilis and Staphylococcus aureus ) bacteria. Antibacterial assay results displayed pronounced activity, and their activity is comparable to that of a standard drug (streptomycin). The antioxidant potential of these compounds was assessed by employing diphenyl picryl hydrazide radical scavenging activity. The results displayed that all the metal chelates have exhibited more bioactivity in contrast with free ligands. The chelation was the main reason for their enhanced bioactivity. These results indicated that the thiazole metal-based compounds could be exploited as antioxidant and antimicrobial candidates.

show abstract

Section: Magnetic Susceptibilitymentioning

confidence: 77%

Metal incorporated aminothiazole-derived compounds: synthesis, density function theory analysis,in vitroantibacterial and antioxidant evaluation

et al. 2021

View full text Add to dashboard Cite

show abstract

“…1 H NMR spectrum of the Zn(II) compound, show signal due to protons bound to the azomethine group appeared at 8.97 ppm. This field shift indicates the deprotection of the azomethine proton upon coordination through the nitrogen atom of the azomethine group [17].…”

Section: H Nmr Spectroscopymentioning

confidence: 99%

Synthesis, characterization, anti-bacterial activity study of vanillin Schiff base complexes

Mohammed¹,

Saleh²,

Mustafea³

2021

KUJSS

View full text Add to dashboard Cite

The Fe(II), Co(II), Ni(II) Cu(II), Zn(II) and Hg(II) complexes were prepared by reacting their salts with the derived Schiff base ligands from condensing vanillin and o-phenylenediamine with a ratio (1:1), (2:1) respectively. Ligands and their complexes were distinguished using analytical, physical and spectroscopic methods. The elemental analysis values show that stoichiometry to be 1:1 [M: L]. Molar conductivity measurements detect that the complexes are non-electrolytic. From the information obtained through electronic measurements, magnetic sensitivity. The square planar geometry around of Ni (II) and Cu (II), and tetrahedral geometry around of the other metals. The prepared complexes showed different activity towards inhibiting bacterial growth for E. coli k.pneomonia.

show abstract

“…The bands present at 3012-3053 cm -1 and 1497-1564 cm -1 may be assigned to ν(C-H) and ν(C=C) groups of aromatic rings respectively [10][11]. The far IR spectra show bands at 460-482 cm -1 assigned to ν(M-N) vibrations in all the complexes [12][13].…”

Section: Infrared Spectroscopymentioning

confidence: 99%

Evaluation of antibacterial activity of macrocyclic metal complexes derived from dihydrazone and diketone

Ali

Singh

2016

IJPBR

View full text Add to dashboard Cite

Synthesis of macrocyclic metal complexes of Cr(III) and Fe(III) by the condensation of benzil dihydrazone with 1H-indole-2, 3-dione.The metal complexes were characterized by elemental analysis, molar conductance, magnetic susceptibility, thermal analysis, ESR, infrared, 1H NMR and UV-visible spectroscopy. On the bases of these studies, a fivecoordinate square pyramidal geometry is proposed for all the metal complexes. In vitro antibacterial activity of macrocyclic metal complexes exhibited good results.

show abstract

Synthesis and characterization of bioactive binuclear transition metal complexes of Schiff base ligand derived from 4-amino-pyrimidine-2-one, diacetyl and glycine

Cited by 19 publications

References 32 publications

Metal incorporated aminothiazole-derived compounds: synthesis, density function theory analysis,in vitroantibacterial and antioxidant evaluation

Metal incorporated aminothiazole-derived compounds: synthesis, density function theory analysis,in vitroantibacterial and antioxidant evaluation

Synthesis, characterization, anti-bacterial activity study of vanillin Schiff base complexes

Evaluation of antibacterial activity of macrocyclic metal complexes derived from dihydrazone and diketone

Contact Info

Product

Resources

About