Herein, we describe a practical two-step synthesis of an indolo[3,2-c]quinoline scaffold from substituted 4-methoxyquinolines using Fischer indole method and oxidative aromatization in one-pot under microwave radiation. With this protocol, a biologically active natural product, isocryptolepine, and its analogues can be readily and efficiently accessed. Also, this method has been efficiently utilized to generate a series of novel pyrrole-containing derivatives of this heterocyclic system.
The present work include preparation of some transition metal complexes Cu(II) with Schiff base ligands L1 (benzylideneamino)pyrimidin-2(1H)-one) L, L2(Z)-4-((2hydroxybenzylidene)amino)pyrimidin-2(1H)-one) L2 and L3 4,4'-((1E,1'E)-pentane-2,4diylidenebis(azanylylidene))bis(pyrimidin-2(1H)-one) (pdp). The ligands were prepared from condensation reaction of the benzaldehyde, Salicyaldehyde and Acetylacetone with cytosine respectively. These compounds were characterized by elemental analysis, molar conductivity; magnetic susceptibility measurements, NMR spectroscopy for ligand, electronic and infrared spectroscopy.These complexes were classified into two classes:
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