Synthesis and characterization of an injectable microparticles integrated hydrogel composite biomaterial: In-vivo biocompatibility and inflammatory arthritis treatment

Dhanka, Mukesh; Pawar, Vaishali; Chauhan, Deepak S.; Jain, Nishant Kumar; Prabhuraj, R S; Shetty, Chaitra; Kumawat, Mukesh Kumar; Prasad, Rajendra; Srivastava, Rohit

doi:10.1016/j.colsurfb.2021.111597

Cited by 17 publications

(9 citation statements)

References 51 publications

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“…After incubating in media containing different concentrations of gels for 72 h, no morphology changes of MRC-5 cells were observed (Figure 4a), and the cell viability was high (>93%) even at a strong concentration of 0.5 wt% (Figure 4b), highlighting the non-toxicity to human normal cells. [51,52] Furthermore, the mineral hydrogels reported here are synthesized in a water-based setting with essential elements for life (Fe, Mo). Such excellent biocompatibility stems from its bio-essential components of Fe and Mo, and by its strictly water-based medium.…”

Section: Biocompatibility and Swelling Resistance Studymentioning

confidence: 99%

Mineral Hydrogel from Inorganic Salts: Biocompatible Synthesis, All‐in‐One Charge Storage, and Possible Implications in the Origin of Life

Liu

Lyu

et al. 2021

Adv Funct Materials

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This study reports a novel hydrogel synthesized using only water and the inorganic salts of FeCl 3 .6H 2 O and (NH 4 ) 6 Mo 7 O 24 .4H 2 O, which offers a stable host for various ions (including Li + , Na + , Mg 2+ , Zn 2+ , Mn 2+ , or Ca 2+ ), affording high ionic conductivity. More interestingly, the redox pair Fe 2+ / Fe 3+ of the gel renders considerable pseudo-capacitance, delivering a high volumetric energy density (4.8 mWh cm −3 , based on the one-piece half-cell) and cycling stability. This simple one-piece approach is convenient and effective-by pairing the mineral gel-based half-cell with another matching electrode, a novel type of charge storage device is formed, with the gel serving as one electroactive material, the electrolyte, and the membrane separator. Furthermore, the mineral hydrogel reported here is of low cytotoxicity, self-bondable and healable, and highly resistant against swelling and disintegrating, with no collapse or volume expansion observed even after being soaked in water for 60 days. To our knowledge, this is the first time that mineral hydrogels have been synthesized from all-inorganic agents in a fully biocompatible setting, which also sheds light on the myth-ridden topic of pre-cell evolution in the prebiotic age.

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Section: Biocompatibility and Swelling Resistance Studymentioning

confidence: 99%

Mineral Hydrogel from Inorganic Salts: Biocompatible Synthesis, All‐in‐One Charge Storage, and Possible Implications in the Origin of Life

Liu

Lyu

et al. 2021

Adv Funct Materials

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“…The polymer has the advantages of low toxicity and good biocompatibility, so it has a wide range of applications in pharmacology. 26 For example, Piotto et al 27 loaded clofazimine into a hydrogel prepared from nanocellulose and Tween-20 for drug release. It was found that the hydrogel was formed by ionic action, and its drug loading was as high as 37%, which can increase the solubility of the drug in water by about 50 times without requiring complicated preparation steps.…”

Section: Introductionmentioning

confidence: 99%

Preparation of pH‐responsive cellulose nanofibril/sodium alginate based hydrogels for drug release

Luan

Liu

et al. 2021

J of Applied Polymer Sci

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In this work, hydrogels composed of cellulose nanofibril (CNF) and sodium alginate (SA) were prepared as a pH-responsive release system by controlling the amount of CNF and SA. Scanning electron microscopy, thermogravimetric analysis, and swelling rate methods were used to characterize. The results showed that when the mass ratio of CNF to SA was 2:1, CNF/SA hydrogels with better morphology were obtained. Due to the deprotonation or protonation of calcium alginate, as the pH changing from 1.5 to 11.0, the swelling ratio increased from 7 times to 19 times compared with its dry weight. The

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“…In the FTIR spectrum of OSA, the absorption peak at 1737 cm −1 attributed to aldehyde groups indicated the forming of OSA by oxidation of the SA 30 . As the FTIR spectrum of CMCS/OSA hydrogel, the aldehyde peak locked at 1735 cm −1 was disappeared, while a new peak appeared at 1625 cm −1 attributed to imine group, indicating the amino group of CMCS reacted with the aldehyde group of OSA 31 . Furthermore, the absorption peaks at 3445 cm −1 were split into two peaks, usually a sign of crosslinking occurred between amino group and dialdehyde group.…”

Section: Resultsmentioning

confidence: 96%

“…30 As the FTIR spectrum of CMCS/OSA hydrogel, the aldehyde peak locked at 1735 cm À1 was disappeared, while a new peak appeared at 1625 cm À1 attributed to imine group, indicating the amino group of CMCS reacted with the aldehyde group of OSA. 31 Furthermore, the absorption peaks at 3445 cm À1 were split into two peaks, usually a sign of crosslinking occurred between amino group and dialdehyde group. In spectrum of the MPs/CMCS/OSA hydrogel, the peaks ascribed to bending and stretching vibrations of CH 2 at 1325 and 2932 cm À1 were moved to 1322 and 2926 cm À1 , respectively.…”

Section: Sample Characterizationmentioning

confidence: 99%

Microparticle‐hydrogel hybrids for sustained release of dual bioactive compounds

Deng

Chen

et al. 2022

Polymers for Advanced Techs

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A novel Cur/TPP-β-CD/CS/Vc microparticles (MPs) filled CMCS/OSA composite hydrogel was prepared by dispersed the chitosan/vitamin C (CS/Vc) complex and curcumin/TPP-β-cyclodextrin (Cur/TPP-β-CD) complex in the hydrogel precursor of oxidized sodium alginate (OSA) and carboxymethyl chitosan (CMCS). Structural properties of the MPs/CMCS/OSA composite hydrogel were characterized by Fourier transform infrared, scanning electron microscope, TG, rheological, and texture analyzer. It was found that the polymeric MPs with a diameter of about 2.5 μm were homogenously embedded in the composite hydrogel by hydrogen bonding and electronic force, resulting in obvious enhanced mechanical strength and stability of the MPs hybrid hydrogel. In vitro release studies show that the release of Cur and Vc can be more efficiently controlled by the different encapsulation pathways. Moreover, the preferential release of the Cur than that of Vc has been confirmed by the twodimensional ultraviolet correlation spectroscopy. Therefore, the MPs/CMCS/OSA composite hydrogel can be used for independently controlled release of dual bioactive compounds during codelivery.

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Synthesis and characterization of an injectable microparticles integrated hydrogel composite biomaterial: In-vivo biocompatibility and inflammatory arthritis treatment

Cited by 17 publications

References 51 publications

Mineral Hydrogel from Inorganic Salts: Biocompatible Synthesis, All‐in‐One Charge Storage, and Possible Implications in the Origin of Life

Mineral Hydrogel from Inorganic Salts: Biocompatible Synthesis, All‐in‐One Charge Storage, and Possible Implications in the Origin of Life

Preparation of pH‐responsive cellulose nanofibril/sodium alginate based hydrogels for drug release

Microparticle‐hydrogel hybrids for sustained release of dual bioactive compounds

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