Microparticle‐hydrogel hybrids for sustained release of dual bioactive compounds

Abstract

A novel Cur/TPP-β-CD/CS/Vc microparticles (MPs) filled CMCS/OSA composite hydrogel was prepared by dispersed the chitosan/vitamin C (CS/Vc) complex and curcumin/TPP-β-cyclodextrin (Cur/TPP-β-CD) complex in the hydrogel precursor of oxidized sodium alginate (OSA) and carboxymethyl chitosan (CMCS). Structural properties of the MPs/CMCS/OSA composite hydrogel were characterized by Fourier transform infrared, scanning electron microscope, TG, rheological, and texture analyzer. It was found that the polymeric MPs with a diameter of about 2.5 μm were homogenously embedded in the composite hydrogel by hydrogen bonding and electronic force, resulting in obvious enhanced mechanical strength and stability of the MPs hybrid hydrogel. In vitro release studies show that the release of Cur and Vc can be more efficiently controlled by the different encapsulation pathways. Moreover, the preferential release of the Cur than that of Vc has been confirmed by the twodimensional ultraviolet correlation spectroscopy. Therefore, the MPs/CMCS/OSA composite hydrogel can be used for independently controlled release of dual bioactive compounds during codelivery.

Chitosan-Based Hydrogel-Incorporated Trp-CDs with Antibacterial Properties and pH-Mediated Fluorescence Response as a Smart Food Preservation Material

“…The solubility of chitosan under acidic conditions also makes it a prospective candidate material for processing into hydrogels . CS can be easily dissolved in a vitamin C (VC) solution to improve its water solubility. , However, CS has poor stability and weak mechanical strength, as reported in many studies, which restricts its application. Therefore, enhancing its stability is fundamental, and cross-linking is an efficient strategy to reach this goal.…”

High-Resolution Tracking of Multiple Distributions in Metallic Nanostructures: Advanced Analysis Was Carried Out with Novel 3D Correlation Thermal Field-Flow Fractionation

“…Generic ultraviolet–visible spectroscopy (UV–vis) remains the gold standard for characterizing the LSPR of metallic nanostructures and NPs . However, for studying complex molecular dynamics and reaction mechanisms, it is common to correlate multiple UV–vis spectra as a function of external stimuli in order to generate better spectral resolution and interpretation . Notably, it has been proven that elution profiles from separation techniques can be considered as quasi spectra and thus are suitable for analysis using spectral correlation .…”

“…22 However, for studying complex molecular dynamics and reaction mechanisms, it is common to correlate multiple UV−vis spectra as a function of external stimuli in order to generate better spectral resolution and interpretation. 23 Notably, it has been proven that elution profiles from separation techniques can be considered as quasi spectra and thus are suitable for analysis using spectral correlation. 24 By correlating multiple elution profiles obtained from time-dependent aliquots from reaction solutions, the socalled 2-D correlation size-exclusion chromatography (2D-SEC) has been developed for elucidating reaction mechanisms with higher resolution relative to regular SEC.…”