Preparation of <scp>pH</scp>‐responsive cellulose nanofibril/sodium alginate based hydrogels for drug release

Li, Yuhang; Luan, Yunhao; Liu, Wanyi; Chen, Tiantian; Liu, Pengtao; Liu, Zhong

doi:10.1002/app.51647

Cited by 27 publications

(21 citation statements)

References 39 publications

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“…Experimental data evidence that all the samples reach an equilibrium condition after 4 hours, with swelling ratio values higher than 100%. The presence of cellulose appears to increase the swelling capacity of the material; this behaviour has already been observed in other studies and ascribed to the hydrophilic characteristics of cellulose 42,43 . On the other hand, soybean peroxidase is a water-soluble globular protein able to to form electrostatic interactions with the surrounding environment 44 .…”

Section: Hydrogels Preparation and Characterisationsupporting

confidence: 77%

Soybean peroxidase immobilised on cellulose-alginate hydrogels for removal of recalcitrant organic pollutants in water

et al. 2023

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Section: Hydrogels Preparation and Characterisationsupporting

confidence: 77%

Soybean peroxidase immobilised on cellulose-alginate hydrogels for removal of recalcitrant organic pollutants in water

et al. 2023

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“…The regression coefficients (r) for the Korsmeyer–Peppas model with varying concentrations of AMPS (CAAM-1, CAAM-4, CAAM-6) confirmed that the release mechanism is controlled by diffusion. Based on the Korsmeyer–Peppas model, the release exponent ( n ) values of all hydrogels (CAAM-1, CAAM-2, CAAM-3, CAAM-4, CAAM-6, CAAM-7, CAAM-9) were between <0.5, indicating a Fickian diffusion process [ 41 ].…”

Section: Resultsmentioning

confidence: 99%

Synthesis of Gallic Acid-Loaded Chitosan-Grafted-2-Acrylamido-2-Methylpropane Sulfonic Acid Hydrogels for Oral Controlled Drug Delivery: In Vitro Biodegradation, Antioxidant, and Antibacterial Effects

Chen

Zhu

et al. 2022

Gels

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In this study, chitosan (CS) and 2-acrylamido-2-methylpropane sulfonic acid (AMPS)-based hydrogels were formulated by the free radical polymerization technique for the controlled release of gallic acid. Fourier transform infrared spectroscopy (FTIR) confirmed the successful preparation and loading of gallic acid within the hydrogel network. Differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) confirmed the increased thermal stability of the hydrogels following the crosslinking and polymerization of chitosan and AMPS. In X-ray diffraction analysis (XRD), the crystallinity of the raw materials decreased, indicating strong crosslinking of the reagents and the formation of a new polymeric network of hydrogels. Scanning electron microscopy (SEM) revealed that the hydrogel had a rough, dense, and porous surface, which is consistent with the highly polymerized composition of the hydrogel. After 48 h, the hydrogels exhibited higher swelling at pH 1.2 (swelling ratio of 19.93%) than at pH 7.4 (swelling ratio of 15.65%). The drug release was analyzed using ultraviolet-visible (UV-Vis) spectrophotometer and demonstrated that after 48 h, gallic acid release was maximum at pH 1.2 (85.27%) compared to pH 7.4 (75.19%). The percent porosity (78.36%) and drug loading increased with the increasing concentration of chitosan and AMPS, while a decrease was observed with the increasing concentration of ethylene glycol dimethyl methacrylate (EGDMA). Crosslinking of the hydrogels increased with concentrations of chitosan and EGDMA but decreased with AMPS. In vitro studies demonstrated that the developed hydrogels were biodegradable (8.6% degradation/week) and had antimicrobial (zone of inhibition of 21 and 16 mm against Gram-positive bacteria Escherichia coli and Staphylococcus aureus as well as 13 mm against Gram-negative bacteria Pseudomonas aeruginosa, respectively) and antioxidant (73% DPPH and 70% ABTS) properties. Therefore, the prepared hydrogels could be used as an effective controlled drug delivery system.

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“…In FTIR spectrum of the CA/SA hydrogel, the distinctive peak appeared at 1571 cm −1 is assigned to the carboxylate groups [17]. Moreover, an appeared peak at 1169 cm −1 can be attributed to the C-O-C stretching vibration [18][19][20].…”

Section: Resultsmentioning

confidence: 99%

An injectable cellulose acetate/sodium alginate hydrogels-loaded laponite microsphere as a potential wound healing in nursing care in perioperative period

Wang¹,

Yang

Zhao

2022

Mater. Res. Express

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The aim of this study was developed by a simple method including solution mixing of cellulose acetate/sodium alginate containing laponite (CA/SA-LAP) hydrogel composites with flexible mechanical, physical, and biological properties for wound healing application. The surface properties of the as-prepared CA/SA hydrogel and CA/SA-LAP hydrogel composites were characterized by Fourier transform infrared spectroscopy (FT-IR) and X-Ray Diffraction (XRD). The influence of LAP content (0.1, 0.2, 0.5 wt%), the swelling ratio (171.0 ± 7.0, 143.0 ± 4.0, and 96.6 ± 2.5), degradation rate (65.7 ± 4.0%, 49.0 ± 5.5%, and 19.4 ± 1.4%), mechanical properties elongation at break from 68.3 ± 6.0% to 148.3 ± 5.6%, and the morphology of the CA/SA-LAP was investigated. By increasing the LAP concentration with an average pore size diameter decreased from 300  μm to 225  μm, 150  μm, and 75 μm. The as-prepared CA/SA-LAP dressing has designated good antimicrobial activity against Staphylococcus aureus and Escherichia coli bacteria at 95.9 ± 4.0% and 98.4 ± 1.5% for 24 h and 92.3 ± 4.5% and 96.4 ± 3.5% for 48 h. Furthermore, CA/SA-LAP revealed admirable biocompatibility against human osteosarcoma cell line MG-63. Noticeably, the MTT assay demonstrated that fibroblast proliferation significantly enhanced on 0.5 wt.% LAP in CA/SA-LAP compared to CS/SA hydrogel at 92.6 ± 4.2% and 96.4 ± 3.5% for 24 and 48 h. Systematic in vivo research of the CA/SA-LAP was conducted in the rat bone defect model. The in vivo results proved that the CA/SA-loaded LAP significantly promoted bone healing in rat defects, compared to the CA/SA hydrogels. These results demonstrated the great potential of CA/SA-loaded LAP in wound healing material in nursing care application.

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Preparation of pH‐responsive cellulose nanofibril/sodium alginate based hydrogels for drug release

Cited by 27 publications

References 39 publications

Soybean peroxidase immobilised on cellulose-alginate hydrogels for removal of recalcitrant organic pollutants in water

Soybean peroxidase immobilised on cellulose-alginate hydrogels for removal of recalcitrant organic pollutants in water

Synthesis of Gallic Acid-Loaded Chitosan-Grafted-2-Acrylamido-2-Methylpropane Sulfonic Acid Hydrogels for Oral Controlled Drug Delivery: In Vitro Biodegradation, Antioxidant, and Antibacterial Effects

An injectable cellulose acetate/sodium alginate hydrogels-loaded laponite microsphere as a potential wound healing in nursing care in perioperative period

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