Synthesis and characterization of a glycerol salicylate resin for bioactive root canal sealers

Portella, Fernando Freitas; Santos, Paula Dapper; Lima, Ginia Brito de; Leitune, Vicente Castelo Branco; Petzhold, César Liberato; Collares, Fabrício Mezzomo; Samuel, Susana Maria Werner

doi:10.1111/iej.12149

Cited by 11 publications

(22 citation statements)

References 25 publications

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“…Hardening of the salicylate sealers is promoted by calcium chelation achieved by a 1:5 ratio of calcium hydroxide to resin . To ensure correct stoichiometry of the chemical reaction, 30 wt % of inorganic compounds with at least 15% calcium hydroxide was used for the development of sealers.…”

Section: Discussionmentioning

confidence: 99%

“…Experimental sealers were obtained by mixing a glycerol salicylate resin, synthesized according to Portella et al, calcium hydroxide, and α‐tricalcium phosphate. All sealers were composed by 70 wt % resin and 30 wt % inorganic components.…”

Section: Methodsmentioning

confidence: 99%

“…Time required to harden the sealers was assessed according to a previous study . The sealers were manipulated, placed on cylindrical matrixes, and stored in a humid cabinet at 36°C.…”

Section: Methodsmentioning

confidence: 99%

“…The salicylate resins present a reliable clinical performance due to the anti‐inflammatory and biocompatibility properties with a high solubility observed . Portella et al synthesized a trifunctional salicylate resin with 72% efficiency in transesterification reactions at a clinically acceptable setting time. To increase mechanical properties of root canal sealers, bioactive inorganic fillers are incorporated in a resin matrix, such as calcium phosphates.…”

Section: Introductionmentioning

confidence: 99%

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Glycerol salicylate‐based containing α‐tricalcium phosphate as a bioactive root canal sealer

et al. 2015

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The use of bioactive materials instead of inert materials to fill the root canal space could be an effective approach to achieve a hermetic seal and stimulate the healing of periapical tissues. The purpose of this study was to develop and characterize an endodontic sealer based on a glycerol salicylate resin and α-tricalcium phosphate (αTCP) at physical and chemical properties. Different sealers were formulated using 70% of a glycerol salicylate resin and 30% of a mixture of calcium hydroxide and αTCP (0, 5, 10, or 15%, in weight). Sealers formulated were characterized based on setting time, in vitro degradation over time, pH, cytotoxicity, and mineral deposition. Sealers presented setting time ranging from 240 to 405 min, and basic pH over 8.21 after 28 days. Higher αTCP concentration leads to sealers with low solubility. Cell viability after 48 h in direct contact with sealers was similar to a commercial sealer used as reference. The 10% and 15% αTCP sealers exhibited a calcium-phosphate layer on the surface after immersion in water and SBF for 7 days. Glycerol salicylate sealers with 10% and 15% α-tricalcium phosphate showed reliable physical-chemical properties and apatite-forming ability.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…Time required to harden the sealers was assessed according to a previous study . The sealers were manipulated, placed on cylindrical matrixes, and stored in a humid cabinet at 36°C.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Glycerol salicylate‐based containing α‐tricalcium phosphate as a bioactive root canal sealer

et al. 2015

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“…Salicylate resin has been used as resin matrix for endodontic sealers since 1999 (14,15). The chemical structure of salicylate derivatives used in the composition of endodontic sealers has direct influence on the properties of the polymer formed during and after the cure (8).…”

Section: Introductionmentioning

confidence: 99%

Pentaerythritol Tetrasalicylate in the Chemical Composition of Root Canal Sealers

et al. 2018

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The aim of this study was to synthesize and evaluate physicochemical properties of a new salicylate derivative in experimental calcium-based root canal sealers. Two salicylate derivatives were synthesized for the transesterification reaction of methyl salicylate with two different alcohols (1,3-butylenoglicol disalicylate-BD and pentaerythritol tetrasalicylate -PT) in molar ratio 1:3 and 1:6, respectively. The products (BD and PT), were characterized by Fourier Transform Infrared Spectroscopy (FTIR) and Nuclear Magnetic Resonance spectroscopy (RMN). Calcium-based experimental sealers were prepared with the same catalyst paste (60% of MTA, 39% of n-ethyl-o-toluenesulfonamide, and 1% titanium dioxide) and four different concentrations of BD and PT in the base pastes

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Antimicrobial and anti-inflammatory drug-delivery systems at endodontic reparative material: Synthesis and characterization

et al. 2019

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Synthesis and characterization of a glycerol salicylate resin for bioactive root canal sealers

Abstract: The new glycerol salicylate resin was successfully synthesized and revealed a potential application in the development of endodontic sealers.

Cited by 11 publications

References 25 publications

Glycerol salicylate‐based containing α‐tricalcium phosphate as a bioactive root canal sealer

Glycerol salicylate‐based containing α‐tricalcium phosphate as a bioactive root canal sealer

Pentaerythritol Tetrasalicylate in the Chemical Composition of Root Canal Sealers

Antimicrobial and anti-inflammatory drug-delivery systems at endodontic reparative material: Synthesis and characterization

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